STRINGSTRING
ERBB4 ERBB4 IGF1 IGF1 WNT16 WNT16 CSF3 CSF3 ROR1 ROR1 PDGFA PDGFA LEP LEP PRR5 PRR5 OSM OSM AGT AGT UNC5B UNC5B TEK TEK NCF1 NCF1 SEMA4D SEMA4D EGF EGF PTPN6 PTPN6 HAX1 HAX1 PDGFRB PDGFRB IGF1R IGF1R NTRK1 NTRK1 KDR KDR HCLS1 HCLS1 MYOC MYOC JAK2 JAK2 PPARD PPARD DCN DCN FSHR FSHR ANGPT1 ANGPT1 HGF HGF HCST HCST SRC SRC SERPINA12 SERPINA12 FLT1 FLT1 FGFR1 FGFR1 MYDGF MYDGF MAZ MAZ TREM2 TREM2 RGL2 RGL2 SIRT1 SIRT1 FLT3 FLT3 SELP SELP ROR2 ROR2 NKX3-1 NKX3-1 SEMA3E SEMA3E PLXNB1 PLXNB1 GPER1 GPER1 PTK2 PTK2 F2R F2R CAT CAT RELN RELN CBL CBL UBE3A UBE3A KIT KIT PRR5L PRR5L PIK3AP1 PIK3AP1 TGFB2 TGFB2 FN1 FN1 CD28 CD28 FGR FGR PDGFB PDGFB AGAP2 AGAP2 NEDD4 NEDD4 SOX9 SOX9 NTRK2 NTRK2 PDGFC PDGFC IL18 IL18 F2 F2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
IGF1Insulin like growth factor 1. (208 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CSF3Colony stimulating factor 3. (207 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (249 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
PRR5Uncharacterized protein. (379 aa)
OSMUncharacterized protein. (252 aa)
AGTAngiotensinogen preproprotein; Belongs to the serpin family. (485 aa)
UNC5BUnc-5 netrin receptor B. (945 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (626 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
NTRK1Tyrosine-protein kinase receptor. (816 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
HCLS1SH3 domain-containing protein. (551 aa)
MYOCMyocilin. (491 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform 1. (441 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
ANGPT1Angiopoietin-1 isoform 1. (498 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
HCSTHematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] (79 aa)
SRCTyrosine-protein kinase. (644 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (414 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1474 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
MYDGFMyeloid derived growth factor. (205 aa)
MAZMYC associated zinc finger protein. (493 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (291 aa)
RGL2Ral guanine nucleotide dissociation stimulator-like 2. (777 aa)
SIRT1Sirtuin 1. (743 aa)
FLT3Fms related tyrosine kinase 3. (904 aa)
SELPSelectin P. (830 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
NKX3-1Homeobox protein Nkx-3.1. (232 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
PLXNB1Plexin B1. (2140 aa)
GPER1G-protein coupled estrogen receptor 1; G-protein coupled estrogen receptor that binds to 17-beta- estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine [...] (375 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (533 aa)
RELNReelin. (3460 aa)
CBLE3 ubiquitin-protein ligase CBL. (907 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
PRR5LUncharacterized protein. (368 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FN1Fibronectin isoform 1 preproprotein. (2477 aa)
CD28T-cell-specific surface glycoprotein CD28. (220 aa)
FGRTyrosine-protein kinase. (529 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
AGAP2Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform PIKE-L. (1192 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (524 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
F2Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (632 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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