39 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANK2	Ankyrin 2. (4045 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	DSC2	Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (947 aa)
	NRAP	Nebulin related anchoring protein. (1731 aa)
	PKP2	Plakophilin 2. (790 aa)
	SCN2A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
	ANK3	Ankyrin 3. (4375 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
	GJC1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
	PGM5	Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (530 aa)
	JUP	Uncharacterized protein. (744 aa)
	RANGRF	Uncharacterized protein. (186 aa)
	DSP	Desmoplakin. (2871 aa)
	CDH2	Cadherin-2 preproprotein; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
	SLC8A1	J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
	SCN5A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1860 aa)
	CTNNA1	Uncharacterized protein. (906 aa)
	PAK1	Non-specific serine/threonine protein kinase. (575 aa)
	F7H9V3_MACMU	Uncharacterized protein. (584 aa)
	SPTBN4	Spectrin beta chain, brain 3 isoform sigma5. (678 aa)
	VCL	Vinculin. (1134 aa)
	DSG2	Desmoglein 2. (1115 aa)
	KCNA5	Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
	CTNNA3	Catenin alpha-3. (895 aa)
	DLG1	Disks large homolog 1 isoform 2; Belongs to the MAGUK family. (926 aa)
	FHOD1	Formin homology 2 domain containing 1. (1105 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	SCN1A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
	AKAP6	A-kinase anchoring protein 6. (2319 aa)
	SLC2A1	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (669 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
	OBSL1	Obscurin like 1. (1896 aa)
	TMEM65	Transmembrane protein 65. (300 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	SCN1B	Sodium voltage-gated channel beta subunit 1. (402 aa)
	FXYD1	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
	SCN4B	Sodium voltage-gated channel beta subunit 4. (316 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP6	CTNNA3	ENSMMUP00000054039	ENSMMUP00000035808	A-kinase anchoring protein 6.	Catenin alpha-3.	0.506
ANK2	ANK3	ENSMMUP00000034873	ENSMMUP00000004790	Ankyrin 2.	Ankyrin 3.	0.912
ANK2	CTNNB1	ENSMMUP00000034873	ENSMMUP00000062910	Ankyrin 2.	Catenin beta-1.	0.432
ANK2	F7H9V3_MACMU	ENSMMUP00000034873	ENSMMUP00000027373	Ankyrin 2.	Uncharacterized protein.	0.751
ANK2	OBSL1	ENSMMUP00000034873	ENSMMUP00000059846	Ankyrin 2.	Obscurin like 1.	0.545
ANK2	SCN2A	ENSMMUP00000034873	ENSMMUP00000003651	Ankyrin 2.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.400
ANK2	SCN4B	ENSMMUP00000034873	ENSMMUP00000071709	Ankyrin 2.	Sodium voltage-gated channel beta subunit 4.	0.466
ANK2	SCN5A	ENSMMUP00000034873	ENSMMUP00000020800	Ankyrin 2.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.529
ANK2	SPTBN4	ENSMMUP00000034873	ENSMMUP00000027374	Ankyrin 2.	Spectrin beta chain, brain 3 isoform sigma5.	0.752
ANK3	ANK2	ENSMMUP00000004790	ENSMMUP00000034873	Ankyrin 3.	Ankyrin 2.	0.912
ANK3	F7H9V3_MACMU	ENSMMUP00000004790	ENSMMUP00000027373	Ankyrin 3.	Uncharacterized protein.	0.810
ANK3	OBSL1	ENSMMUP00000004790	ENSMMUP00000059846	Ankyrin 3.	Obscurin like 1.	0.402
ANK3	SCN1A	ENSMMUP00000004790	ENSMMUP00000052582	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.422
ANK3	SCN2A	ENSMMUP00000004790	ENSMMUP00000003651	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.629
ANK3	SCN5A	ENSMMUP00000004790	ENSMMUP00000020800	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.695
ANK3	SPTBN4	ENSMMUP00000004790	ENSMMUP00000027374	Ankyrin 3.	Spectrin beta chain, brain 3 isoform sigma5.	0.811
CDH2	CTNNA1	ENSMMUP00000019908	ENSMMUP00000023641	Cadherin-2 preproprotein; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.846
CDH2	CTNNA3	ENSMMUP00000019908	ENSMMUP00000035808	Cadherin-2 preproprotein; Cadherins are calcium-dependent cell adhesion proteins.	Catenin alpha-3.	0.604
CDH2	CTNNB1	ENSMMUP00000019908	ENSMMUP00000062910	Cadherin-2 preproprotein; Cadherins are calcium-dependent cell adhesion proteins.	Catenin beta-1.	0.979
CDH2	DSP	ENSMMUP00000019908	ENSMMUP00000019406	Cadherin-2 preproprotein; Cadherins are calcium-dependent cell adhesion proteins.	Desmoplakin.	0.545