(18 nodes) Phasic smooth muscle contraction network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	P2RX3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (468 aa)
	DLG1	Disks large homolog 1 isoform 2; Belongs to the MAGUK family. (926 aa)
	GDNF	Glial cell derived neurotrophic factor. (342 aa)
	PTGER3	Prostaglandin E receptor 3. (460 aa)
	EDN2	Endothelin 2. (206 aa)
	P2RX2	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (496 aa)
	TACR2	Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (398 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (481 aa)
	NEUROG1	Neurogenin 1. (237 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	HTR1D	5-hydroxytryptamine receptor 1D. (377 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (527 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	SSTR2	Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (402 aa)
	EDN3	Endothelin 3. (257 aa)
	TIFAB	TIFA inhibitor. (204 aa)
	EDN1	Preproendothelin-1. (211 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DRD2	EDN1	ENSMMUP00000018833	ENSMMUP00000062615	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Preproendothelin-1.	0.732
DRD2	EDN2	ENSMMUP00000018833	ENSMMUP00000021310	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Endothelin 2.	0.698
DRD2	EDN3	ENSMMUP00000018833	ENSMMUP00000073429	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Endothelin 3.	0.721
DRD2	SSTR2	ENSMMUP00000018833	ENSMMUP00000073705	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.542
EDN1	DRD2	ENSMMUP00000062615	ENSMMUP00000018833	Preproendothelin-1.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.732
EDN1	EDN2	ENSMMUP00000062615	ENSMMUP00000021310	Preproendothelin-1.	Endothelin 2.	0.954
EDN1	EDN3	ENSMMUP00000062615	ENSMMUP00000073429	Preproendothelin-1.	Endothelin 3.	0.959
EDN1	EDNRB	ENSMMUP00000062615	ENSMMUP00000051513	Preproendothelin-1.	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.998
EDN1	HTR1D	ENSMMUP00000062615	ENSMMUP00000040533	Preproendothelin-1.	5-hydroxytryptamine receptor 1D.	0.730
EDN1	PTGER3	ENSMMUP00000062615	ENSMMUP00000022774	Preproendothelin-1.	Prostaglandin E receptor 3.	0.721
EDN1	SSTR2	ENSMMUP00000062615	ENSMMUP00000073705	Preproendothelin-1.	Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.717
EDN2	DRD2	ENSMMUP00000021310	ENSMMUP00000018833	Endothelin 2.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.698
EDN2	EDN1	ENSMMUP00000021310	ENSMMUP00000062615	Endothelin 2.	Preproendothelin-1.	0.954
EDN2	EDN3	ENSMMUP00000021310	ENSMMUP00000073429	Endothelin 2.	Endothelin 3.	0.953
EDN2	EDNRB	ENSMMUP00000021310	ENSMMUP00000051513	Endothelin 2.	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.988
EDN2	HTR1D	ENSMMUP00000021310	ENSMMUP00000040533	Endothelin 2.	5-hydroxytryptamine receptor 1D.	0.698
EDN2	PTGER3	ENSMMUP00000021310	ENSMMUP00000022774	Endothelin 2.	Prostaglandin E receptor 3.	0.678
EDN2	SSTR2	ENSMMUP00000021310	ENSMMUP00000073705	Endothelin 2.	Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.677
EDN3	DRD2	ENSMMUP00000073429	ENSMMUP00000018833	Endothelin 3.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.721
EDN3	EDN1	ENSMMUP00000073429	ENSMMUP00000062615	Endothelin 3.	Preproendothelin-1.	0.959