STRINGSTRING
P2RX1 P2RX1 ABCG5 ABCG5 KCNQ1 KCNQ1 APOB APOB SLC10A4 SLC10A4 NPC2 NPC2 CYP7A1 CYP7A1 TSPO TSPO SLC22A3 SLC22A3 SLC22A2 SLC22A2 SCP2 SCP2 SOAT2 SOAT2 SELENOM SELENOM APOA2 APOA2 OSBPL1A OSBPL1A SLC10A6 SLC10A6 SLC6A4 SLC6A4 AQP3 AQP3 SLC5A12 SLC5A12 RELCH RELCH OSBPL6 OSBPL6 GRAMD1C GRAMD1C OSBP OSBP SLC5A11 SLC5A11 STARD3 STARD3 MAPK15 MAPK15 NPC1L1 NPC1L1 FGF19 FGF19 SLC29A4 SLC29A4 ABCC3 ABCC3 APOC2 APOC2 APOA5 APOA5 SLC16A1 SLC16A1 ABCG4 ABCG4 ENSMMUP00000075519 ENSMMUP00000075519 RALBP1 RALBP1 CD36 CD36 SLC51B SLC51B SLCO1A2 SLCO1A2 CERS5 CERS5 CEL CEL STARD4 STARD4 SLC16A3 SLC16A3 ABCG8 ABCG8 TPCN2 TPCN2 SERAC1 SERAC1 LDLRAP1 LDLRAP1 CLU CLU LCAT LCAT SLC16A7 SLC16A7 UBL4A UBL4A TSPO2 TSPO2 SCARB1 SCARB1 OSBPL11 OSBPL11 SLC6A3 SLC6A3 LRP6 LRP6 SYK SYK EMB EMB SLC16A8 SLC16A8 GHRL GHRL CEACAM1 CEACAM1 AQP7 AQP7 TSKU TSKU STARD3NL STARD3NL ABCA1 ABCA1 NPC1 NPC1 SLC10A2 SLC10A2 ABCG1 ABCG1 PARK7 PARK7 SLC10A7 SLC10A7 MECP2 MECP2 AQP2 AQP2 LIPC LIPC HNF1A HNF1A OSBPL8 OSBPL8 GRAMD1A GRAMD1A PINK1 PINK1 LDLR LDLR SYT7 SYT7 OSBPL10 OSBPL10 MFSD10 MFSD10 SLC18A2 SLC18A2 ATP8B1 ATP8B1 GRAMD1B GRAMD1B ABCD3 ABCD3 ABCA8 ABCA8 APOE APOE SOAT1 SOAT1 SLC10A5 SLC10A5 STRA6 STRA6 ADRM1 ADRM1 OSBPL5 OSBPL5 PODN PODN SLCO1B1 SLCO1B1 SLC26A6 SLC26A6 ARL8A ARL8A ACADL ACADL ARV1 ARV1 APOM APOM SLC22A1 SLC22A1 MSR1 MSR1 APOC1 APOC1 ABCC2 ABCC2 AQP10 AQP10 SLC51A SLC51A SLC10A1 SLC10A1 ABCC4 ABCC4 CHRM3 CHRM3 ASIC3 ASIC3 PRKN PRKN SLC6A2 SLC6A2 SLC18A1 SLC18A1 VIP VIP LIPG LIPG OSBPL7 OSBPL7 AQP11 AQP11 ABCA5 ABCA5 OSBP2 OSBP2 SLC27A5 SLC27A5 CETP CETP OSBPL3 OSBPL3 WNK4 WNK4 APOA1 APOA1 ABCA7 ABCA7 SLC5A8 SLC5A8 PIP4K2A PIP4K2A ABCA12 ABCA12 DRD2 DRD2 SPG11 SPG11 CHRM5 CHRM5 ABCA4 ABCA4 ABCB11 ABCB11 LSM1 LSM1 CCDC180 CCDC180 STARD5 STARD5 AQP9 AQP9 NR0B2 NR0B2 SLC2A13 SLC2A13 PLTP PLTP CES1 CES1 SLCO2B1 SLCO2B1 MTTP MTTP ARL8B ARL8B ABCC11 ABCC11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
ABCG5ATP binding cassette subfamily G member 5. (650 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
APOBApolipoprotein B. (4555 aa)
SLC10A4Solute carrier family 10 member 4. (436 aa)
NPC2NPC intracellular cholesterol transporter 2. (151 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
TSPOTranslocator protein isoform PBR. (169 aa)
SLC22A3Solute carrier family 22 member 3. (555 aa)
SLC22A2Solute carrier family 22 member 2. (550 aa)
SCP2Non-specific lipid-transfer protein isoform 1 proprotein; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
SOAT2O-acyltransferase. (526 aa)
SELENOMSelenoprotein M. (144 aa)
APOA2Truncated apolipoprotein A-II; Apo A-II makes up about 20% of the protein of the HDL (high density lipoprotein) phospholipid-rich fraction in plasma; Belongs to the apolipoprotein A2 family. (100 aa)
OSBPL1AOxysterol-binding protein; Belongs to the OSBP family. (949 aa)
SLC10A6Solute carrier family 10 member 6. (377 aa)
SLC6A4Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. (630 aa)
AQP3Aquaporin-3; Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
SLC5A12Solute carrier family 5 member 12; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (618 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
OSBPL6Oxysterol-binding protein; Belongs to the OSBP family. (967 aa)
GRAMD1CGRAM domain containing 1C. (679 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (805 aa)
SLC5A11Solute carrier family 5 member 11; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (675 aa)
STARD3StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (By similarity). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (By similarity). May also mediate cholesterol transport between other membra [...] (445 aa)
MAPK15Mitogen-activated protein kinase. (544 aa)
NPC1L1SSD domain-containing protein. (1363 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
SLC29A4Solute carrier family 29 member 4. (553 aa)
ABCC3ATP binding cassette subfamily C member 3. (1535 aa)
APOC2Uncharacterized protein. (184 aa)
APOA5Apolipoprotein A5. (366 aa)
SLC16A1Solute carrier family 16 member 1. (499 aa)
ABCG4ATP binding cassette subfamily G member 4. (646 aa)
ENSMMUP00000075519Uncharacterized protein. (620 aa)
RALBP1RalA binding protein 1. (655 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
SLC51BOrganic solute transporter subunit beta. (130 aa)
SLCO1A2Solute carrier organic anion transporter family member. (670 aa)
CERS5Ceramide synthase 5. (751 aa)
CELCarboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family. (704 aa)
STARD4StAR-related lipid transfer protein 4. (205 aa)
SLC16A3Solute carrier family 16 member 3. (465 aa)
ABCG8ATP binding cassette subfamily G member 8. (716 aa)
TPCN2Two pore segment channel 2. (823 aa)
SERAC1Serine active site containing 1. (654 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (320 aa)
CLUClusterin; Belongs to the clusterin family. (489 aa)
LCATLecithin-cholesterol acyltransferase. (471 aa)
SLC16A7Solute carrier family 16 member 7. (478 aa)
UBL4AUbiquitin like 4A. (561 aa)
TSPO2Uncharacterized protein. (170 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (554 aa)
OSBPL11Oxysterol-binding protein; Belongs to the OSBP family. (760 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (631 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
SYKTyrosine-protein kinase. (635 aa)
EMBEmbigin. (374 aa)
SLC16A8Solute carrier family 16 member 8. (504 aa)
GHRLGhrelin and obestatin prepropeptide. (222 aa)
CEACAM1Uncharacterized protein. (525 aa)
AQP7Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (395 aa)
TSKUUncharacterized protein. (353 aa)
STARD3NLMLN64 N-terminal domain homolog. (234 aa)
ABCA1ATP binding cassette subfamily A member 1. (2266 aa)
NPC1NPC intracellular cholesterol transporter 1. (1297 aa)
SLC10A2Solute carrier family 10 member 2. (348 aa)
ABCG1ATP binding cassette subfamily G member 1. (696 aa)
PARK7Protein DJ-1. (189 aa)
SLC10A7Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (358 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
AQP2Aquaporin-2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
LIPCLipase C, hepatic type. (523 aa)
HNF1AHNF1 homeobox A. (657 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (902 aa)
GRAMD1AGRAM domain containing 1A. (807 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (581 aa)
LDLRUncharacterized protein. (918 aa)
SYT7Synaptotagmin 7. (708 aa)
OSBPL10Oxysterol-binding protein; Belongs to the OSBP family. (769 aa)
MFSD10Major facilitator superfamily domain-containing protein 10. (455 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
ATP8B1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1251 aa)
GRAMD1BGRAM domain containing 1B. (895 aa)
ABCD3ATP binding cassette subfamily D member 3. (672 aa)
ABCA8ATP binding cassette subfamily A member 8. (1621 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
SOAT1O-acyltransferase. (550 aa)
SLC10A5Solute carrier family 10 member 5. (443 aa)
STRA6Stimulated by retinoic acid 6. (707 aa)
ADRM1Oxysterol-binding protein; Belongs to the OSBP family. (854 aa)
OSBPL5Oxysterol-binding protein; Belongs to the OSBP family. (971 aa)
PODNPodocan. (662 aa)
SLCO1B1Solute carrier organic anion transporter family member. (747 aa)
SLC26A6Solute carrier family 26 member 6. (756 aa)
ARL8AADP ribosylation factor like GTPase 8A; Belongs to the small GTPase superfamily. Arf family. (195 aa)
ACADLKAT8 regulatory NSL complex subunit 1 like. (1095 aa)
ARV1ARV1 homolog, fatty acid homeostasis modulator. (271 aa)
APOMApolipoprotein M. (188 aa)
SLC22A1Solute carrier family 22 member 1. (554 aa)
MSR1Macrophage scavenger receptor 1. (451 aa)
APOC1Cholesteryl ester transfer inhibitor protein; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. [...] (83 aa)
ABCC2Uncharacterized protein. (1545 aa)
AQP10Aquaporin 10; Belongs to the MIP/aquaporin (TC 1.A.8) family. (301 aa)
SLC51AOrganic solute transporter subunit alpha. (340 aa)
SLC10A1Solute carrier family 10 member a1. (349 aa)
ABCC4ATP binding cassette subfamily C member 4. (1325 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (547 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
SLC6A2Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (628 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
VIPVIP peptides isoform 1 preproprotein. (170 aa)
LIPGLipase G, endothelial type. (500 aa)
OSBPL7Oxysterol-binding protein; Belongs to the OSBP family. (842 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
ABCA5ATP binding cassette subfamily A member 5. (1642 aa)
OSBP2Oxysterol-binding protein; Belongs to the OSBP family. (920 aa)
SLC27A5Solute carrier family 27 member 5. (690 aa)
CETPCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (500 aa)
OSBPL3Oxysterol-binding protein; Belongs to the OSBP family. (887 aa)
WNK4WNK lysine deficient protein kinase 4. (1242 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (267 aa)
ABCA7ATP binding cassette subfamily A member 7. (2111 aa)
SLC5A8Solute carrier family 5 member 8; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (611 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (432 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2487 aa)
CHRM5Muscarinic acetylcholine receptor M5; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily. (532 aa)
ABCA4ATP binding cassette subfamily A member 4. (2273 aa)
ABCB11ATP binding cassette subfamily B member 11. (1323 aa)
LSM1Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
CCDC180Coiled-coil domain containing 180. (1694 aa)
STARD5StAR related lipid transfer domain containing 5. (216 aa)
AQP9Aquaporin-9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
SLC2A13Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (647 aa)
PLTPPhospholipid transfer protein. (516 aa)
CES1Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (611 aa)
SLCO2B1Solute carrier organic anion transporter family member. (745 aa)
MTTPMicrosomal triglyceride transfer protein. (894 aa)
ARL8BADP-ribosylation factor-like protein 8B; Belongs to the small GTPase superfamily. Arf family. (186 aa)
ABCC11ATP binding cassette subfamily C member 11. (1382 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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