STRINGSTRING
UBE2E1 UBE2E1 HUWE1 HUWE1 BRCA2 BRCA2 WAC WAC PCGF6 PCGF6 CUL4B CUL4B BMI1 BMI1 CTR9 CTR9 UHRF1 UHRF1 RNF2 RNF2 ATXN7L3 ATXN7L3 RNF40 RNF40 RAD51 RAD51 KDM2B KDM2B TRIM37 TRIM37 PCGF5 PCGF5 UBE2N UBE2N SKP1-2 SKP1-2 RYBP RYBP UBE2A UBE2A DTX3L DTX3L PHC1 PHC1 PCGF3 PCGF3 DDB1 DDB1 PCGF2 PCGF2 CDC73 CDC73 UBE2B UBE2B RAG1 RAG1 RNF20 RNF20 UBR2 UBR2 CBX8 CBX8 SUZ12 SUZ12 PCGF1 PCGF1 LEO1 LEO1 RING1 RING1 RNF168 RNF168 BCOR BCOR BARD1 BARD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (447 aa)
HUWE1E3 ubiquitin-protein ligase HUWE1. (4374 aa)
BRCA2BRCA2 DNA repair associated. (3377 aa)
WACWW domain containing adaptor with coiled-coil. (657 aa)
PCGF6Polycomb group ring finger 6. (350 aa)
CUL4BCullin 4B; Belongs to the cullin family. (933 aa)
BMI1RING-type domain-containing protein. (469 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (795 aa)
RNF2E3 ubiquitin-protein ligase RING2. (336 aa)
ATXN7L3Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] (347 aa)
RNF40E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1001 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (380 aa)
KDM2BLysine demethylase 2B. (1340 aa)
TRIM37Uncharacterized protein. (983 aa)
PCGF5Polycomb group ring finger 5. (261 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
SKP1-2Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
RYBPRanBP2-type domain-containing protein. (755 aa)
UBE2AUbiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (224 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (740 aa)
PHC1Uncharacterized protein. (1019 aa)
PCGF3RING-type domain-containing protein. (265 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
PCGF2Polycomb group RING finger protein 2. (344 aa)
CDC73Parafibromin. (531 aa)
UBE2BUbiquitin-conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1081 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
CBX8Chromobox 8. (539 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
PCGF1Polycomb group RING finger protein 1. (259 aa)
LEO1RNA polymerase-associated protein LEO1. (666 aa)
RING1E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...] (406 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (661 aa)
BCORBCL6 corepressor. (1752 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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