STRINGSTRING
RABGEF1 RABGEF1 SYT5 SYT5 KLRC2 KLRC2 FES FES WDR41 WDR41 RAB3GAP1 RAB3GAP1 CASK CASK SYT7 SYT7 ITGAM ITGAM LYN LYN WNT7A WNT7A PCLO PCLO STXBP5 STXBP5 NOTCH1 NOTCH1 SYT4 SYT4 REST REST GRIN3A GRIN3A C15H9orf72 C15H9orf72 GATA1 GATA1 TRPV6 TRPV6 LRRK2 LRRK2 CD84 CD84 STXBP6 STXBP6 C11H12orf4 C11H12orf4 RAB2B RAB2B VPS18 VPS18 DRD2 DRD2 PDCD6IP PDCD6IP RAB3B RAB3B NRXN3 NRXN3 FER FER LGI3 LGI3 PDPK1 PDPK1 F7B371_MACMU F7B371_MACMU SYT13 SYT13 SNX4 SNX4 CHRNA5 CHRNA5 SYT10 SYT10 CACNB4 CACNB4 LAMP1 LAMP1 BCR BCR MAMU-F MAMU-F P2RX1 P2RX1 BACE1 BACE1 CLASP1 CLASP1 CACNB2 CACNB2 SLC4A8 SLC4A8 KCNB1 KCNB1 ENSMMUP00000057803 ENSMMUP00000057803 STXBP2 STXBP2 FMR1 FMR1 CD160 CD160 GAB2 GAB2 CLASP2 CLASP2 SDCBP SDCBP GSK3B GSK3B RIMS4 RIMS4 SEPTIN5 SEPTIN5 ADORA2B ADORA2B PRKCB PRKCB TSG101 TSG101 CEACAM1 CEACAM1 RAB27B RAB27B RIMS2 RIMS2 VSNL1 VSNL1 SDC1 SDC1 CPLANE2 CPLANE2 FOXF1 FOXF1 SYK SYK GIPC1 GIPC1 DOC2B DOC2B RAB3C RAB3C NLGN1 NLGN1 CNR2 CNR2 STX1B STX1B IL4 IL4 IL13 IL13 UNC13D UNC13D PLA2G6 PLA2G6 IL1RAPL1 IL1RAPL1 ATP13A2 ATP13A2 CADPS CADPS RAC2 RAC2 ATP9A ATP9A SYT6 SYT6 CACNA1H CACNA1H GIT1 GIT1 CBARP CBARP RPH3AL RPH3AL APBA1 APBA1 RAPGEF4 RAPGEF4 SYT11 SYT11 ADRA1A ADRA1A ANXA1 ANXA1 RAB3D-2 RAB3D-2 SYT2 SYT2 RAB7A RAB7A CHRM2 CHRM2 SYP SYP FGR FGR SYT3 SYT3 SYT1 SYT1 GATA2 GATA2 P2RY1 P2RY1 SYT8 SYT8 CDK5R2 CDK5R2 CACNA1I CACNA1I VAMP8 VAMP8 SYT15 SYT15 CACNA1G CACNA1G SPHK2 SPHK2 PRKCG PRKCG KIAA0100 KIAA0100 MICAL1 MICAL1 RAB9A RAB9A FGG FGG FGA FGA FGB FGB SNF8 SNF8 CD177 CD177 RAB33B RAB33B CDK5 CDK5 PRKN PRKN H9H440_MACMU H9H440_MACMU SMPD3 SMPD3 BLK BLK CSPG5 CSPG5 HYAL3 HYAL3 STXBP5L STXBP5L ENSMMUP00000042210 ENSMMUP00000042210 CADPS2 CADPS2 STXBP3 STXBP3 ATP2A2 ATP2A2 BRAF BRAF RPH3A RPH3A STX1A STX1A DVL1 DVL1 RAB15 RAB15 DGKI DGKI EXPH5 EXPH5 STAM STAM S100A10 S100A10 DOC2A DOC2A CHMP2A CHMP2A PFN2 PFN2 RALA RALA IL4R IL4R LOC721699 LOC721699 ADCY1 ADCY1 CNR1 CNR1 RAP1A RAP1A SYN1 SYN1 GIPC3 GIPC3 SDC4 SDC4 SMPD5 SMPD5 HGS HGS TPCN2 TPCN2 PLA2G3 PLA2G3 RIMS3 RIMS3 FBXL20 FBXL20 RAB27A RAB27A SNAPIN SNAPIN ITGB2 ITGB2 RAB21 RAB21 PRAM1 PRAM1 SYTL4 SYTL4 RAB26 RAB26 DTNBP1 DTNBP1 RAB12 RAB12 SYNPR SYNPR RAB13 RAB13 PFN1 PFN1 PREPL PREPL NCKAP1L NCKAP1L SYT12 SYT12 RAB8B RAB8B LOC114675624 LOC114675624 GIPC2 GIPC2 SMCR8 SMCR8 IL13RA2 IL13RA2 STX4 STX4 SYT9 SYT9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RABGEF1Uncharacterized protein. (492 aa)
SYT5Synaptotagmin 5. (386 aa)
KLRC2NKG2-C type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (415 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
WDR41WD repeat domain 41. (549 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (989 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
SYT7Synaptotagmin 7. (708 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1271 aa)
LYNTyrosine-protein kinase. (577 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5181 aa)
STXBP5Syntaxin binding protein 5. (1152 aa)
NOTCH1Notch receptor 1. (2556 aa)
SYT4Synaptotagmin IV. (425 aa)
RESTRE1 silencing transcription factor. (1095 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
C15H9orf72Uncharacterized protein. (481 aa)
GATA1GATA binding protein 1. (413 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (821 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
CD84CD84 molecule. (345 aa)
STXBP6Syntaxin-binding protein 6. (210 aa)
C11H12orf4Chromosome 11 C12orf4 homolog. (577 aa)
RAB2BRAB2B, member RAS oncogene family. (290 aa)
VPS18Vacuolar protein sorting-associated protein 18-like protein. (973 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
PDCD6IPProgrammed cell death 6-interacting protein isoform 1. (868 aa)
RAB3BRAB3B, member RAS oncogene family. (219 aa)
NRXN3Neurexin 3. (1571 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
LGI3Leucine-rich repeat LGI family member 3. (548 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
F7B371_MACMUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (313 aa)
SYT13Synaptotagmin-13. (426 aa)
SNX4Sorting nexin 4. (450 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (468 aa)
SYT10Synaptotagmin 10. (523 aa)
CACNB4SH3 domain-containing protein. (520 aa)
LAMP1Lysosomal associated membrane protein 1. (733 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
MAMU-FMamu class I histocompatibility antigen, alpha chain F; Involved in the presentation of foreign antigens to the immune system. (348 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
BACE1Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family. (501 aa)
CLASP1Cytoplasmic linker associated protein 1. (1533 aa)
CACNB2SH3 domain-containing protein. (660 aa)
SLC4A8Anion exchange protein. (1093 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
ENSMMUP00000057803MHC_I-like_Ag-recog domain-containing protein. (216 aa)
STXBP2Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (640 aa)
FMR1Fragile X mental retardation 1 protein isoform ISO1. (632 aa)
CD160CD160 molecule. (229 aa)
GAB2GRB2 associated binding protein 2. (677 aa)
CLASP2Uncharacterized protein. (1522 aa)
SDCBPSyndecan binding protein. (324 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
RIMS4Regulating synaptic membrane exocytosis protein 4 isoform 2. (269 aa)
SEPTIN5Septin 5; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (442 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (331 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
TSG101ESCRT-I complex subunit TSG101. (390 aa)
CEACAM1Uncharacterized protein. (525 aa)
RAB27BRAB27B, member RAS oncogene family. (218 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1693 aa)
VSNL1Visinin like 1. (263 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (505 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
FOXF1Forkhead box F1. (432 aa)
SYKTyrosine-protein kinase. (635 aa)
GIPC1PDZ domain-containing protein GIPC1 isoform 1. (333 aa)
DOC2BDouble C2-like domain-containing protein. (408 aa)
RAB3CUncharacterized protein. (231 aa)
NLGN1Neuroligin-1. (823 aa)
CNR2Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (289 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (146 aa)
UNC13DUnc-13 homolog D. (1090 aa)
PLA2G6Phospholipase A2 group VI. (935 aa)
IL1RAPL1Interleukin-1 receptor accessory protein-like 1. (696 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1249 aa)
CADPSUncharacterized protein. (1393 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
ATP9APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1120 aa)
SYT6Synaptotagmin 6. (633 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2352 aa)
GIT1GIT ArfGAP 1. (794 aa)
CBARPCACN subunit beta associated regulatory protein. (752 aa)
RPH3ALRabphilin 3A like (without C2 domains). (321 aa)
APBA1Amyloid beta precursor protein binding family A member 1. (838 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1047 aa)
SYT11Synaptotagmin-11. (431 aa)
ADRA1AAdrenoceptor alpha 1A. (445 aa)
ANXA1Annexin. (367 aa)
RAB3D-2Ras-related protein Rab-3D. (219 aa)
SYT2Synaptotagmin 2. (470 aa)
RAB7ARAB7A, member RAS oncogene family. (220 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (492 aa)
SYPSynaptophysin. (401 aa)
FGRTyrosine-protein kinase. (529 aa)
SYT3Synaptotagmin-3. (590 aa)
SYT1Synaptotagmin 1. (422 aa)
GATA2GATA binding protein 2. (480 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
SYT8Synaptotagmin 8. (476 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2111 aa)
VAMP8Vesicle-associated membrane protein 8. (100 aa)
SYT15Uncharacterized protein. (422 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
SPHK2DAGKc domain-containing protein. (669 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
KIAA0100KIAA0100. (2235 aa)
MICAL1Microtubule associated monooxygenase, calponin and LIM domain containing 1. (1069 aa)
RAB9ARas-related protein Rab-9A. (201 aa)
FGGFibrinogen gamma chain. (437 aa)
FGAFibrinogen alpha chain. (928 aa)
FGBFibrinogen beta chain. (491 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
CD177CD177 molecule. (424 aa)
RAB33BRas-related protein Rab-33B. (229 aa)
CDK5Cyclin dependent kinase 5. (364 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
H9H440_MACMUMHC_I-like_Ag-recog domain-containing protein. (128 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
BLKTyrosine-protein kinase. (568 aa)
CSPG5Chondroitin sulfate proteoglycan 5. (562 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
STXBP5LSyntaxin binding protein 5 like. (1200 aa)
ENSMMUP00000042210Profilin; Belongs to the profilin family. (186 aa)
CADPS2Calcium dependent secretion activator 2. (1303 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1011 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
RPH3ARabphilin 3A. (694 aa)
STX1ASyntaxin-1A isoform 1; Belongs to the syntaxin family. (288 aa)
DVL1Dishevelled segment polarity protein 1. (695 aa)
RAB15RAB15, member RAS oncogene family. (225 aa)
DGKIDiacylglycerol kinase. (1100 aa)
EXPH5Exophilin 5. (2033 aa)
STAMSignal transducing adapter molecule 1. (540 aa)
S100A10Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (227 aa)
DOC2ADouble C2 domain alpha. (498 aa)
CHMP2ACharged multivesicular body protein 2a. (222 aa)
PFN2Profilin; Belongs to the profilin family. (412 aa)
RALARas-related protein Ral-A. (206 aa)
IL4RInterleukin 4 receptor. (825 aa)
LOC721699Uncharacterized protein. (387 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (By similarity). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. In [...] (472 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
SYN1Synapsin-1 isoform Ia. (705 aa)
GIPC3PDZ domain-containing protein. (1440 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
SMPD5Uncharacterized protein. (381 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (805 aa)
TPCN2Two pore segment channel 2. (823 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
RIMS3Regulating synaptic membrane exocytosis protein 3. (308 aa)
FBXL20F-box and leucine rich repeat protein 20. (448 aa)
RAB27AUncharacterized protein. (321 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
ITGB2Integrin beta. (911 aa)
RAB21RAB21, member RAS oncogene family. (263 aa)
PRAM1PML-RARA regulated adaptor molecule 1. (736 aa)
SYTL4Synaptotagmin-like protein 4. (670 aa)
RAB26RAB26, member RAS oncogene family. (254 aa)
DTNBP1Dystrobrevin binding protein 1. (425 aa)
RAB12RAB12, member RAS oncogene family. (404 aa)
SYNPRSynaptoporin isoform 1. (285 aa)
RAB13Uncharacterized protein. (245 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
PREPLUncharacterized protein. (727 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
SYT12Synaptotagmin 12. (436 aa)
RAB8BRAB8B, member RAS oncogene family. (286 aa)
LOC114675624Uncharacterized protein; Belongs to the MAGUK family. (450 aa)
GIPC2PDZ domain-containing protein. (319 aa)
SMCR8SMCR8-C9orf72 complex subunit. (936 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (388 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (322 aa)
SYT9Synaptotagmin-9. (491 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (14%) [HD]