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MYO3B MYO3B DCLK1 DCLK1 TAF1 TAF1 MAP3K20 MAP3K20 PRKAA2 PRKAA2 PKN3 PKN3 TTBK2 TTBK2 TGFBR2 TGFBR2 CAB39 CAB39 CDK5R1 CDK5R1 EIF2AK3 EIF2AK3 MAPK7 MAPK7 RIPK1 RIPK1 MAPK14 MAPK14 ATR ATR TBK1 TBK1 RPS6KA4 RPS6KA4 NEK6 NEK6 MAP3K12 MAP3K12 RPS6KB2 RPS6KB2 CSNK1A1L CSNK1A1L ATM ATM MAPK8 MAPK8 VRK1 VRK1 AURKB AURKB PKD1 PKD1 MAPKAPK3 MAPKAPK3 HIPK4 HIPK4 VRK3 VRK3 PDK3 PDK3 PRKCD PRKCD STK38L STK38L SBK1 SBK1 ULK1 ULK1 STK32A STK32A PLK2 PLK2 MAST1 MAST1 PKN2 PKN2 PINK1 PINK1 PKN1 PKN1 MAP4K1 MAP4K1 CAMK1G CAMK1G TLK2 TLK2 AKT2 AKT2 ENSMMUP00000059946 ENSMMUP00000059946 GSK3B GSK3B AKT1 AKT1 MAP3K13 MAP3K13 PRKCB PRKCB MAST4 MAST4 CAMK4 CAMK4 MAST2 MAST2 HIPK3 HIPK3 SYK SYK PRKX PRKX LOC114675515 LOC114675515 CDC7 CDC7 MASTL MASTL LOC106992273 LOC106992273 SMG1 SMG1 SRPK2 SRPK2 PDGFB PDGFB CAMK1 CAMK1 DCLK3 DCLK3 DYRK2 DYRK2 BAK1 BAK1 MAST3 MAST3 PRKCI PRKCI MST1 MST1 PIKFYVE PIKFYVE BCL2 BCL2 PRKCA PRKCA LATS1 LATS1 GRK2 GRK2 RPS6KA3 RPS6KA3 CAMK2D CAMK2D TGFBR1 TGFBR1 RPS6KB1 RPS6KB1 ULK2 ULK2 RPS6KA6 RPS6KA6 STK32B STK32B ROCK1 ROCK1 RPS6KA2 RPS6KA2 TSSK6 TSSK6 MAPK13 MAPK13 BRSK1 BRSK1 CLSPN CLSPN BRSK2 BRSK2 ULK3 ULK3 MYO3A MYO3A CHUK CHUK VRK2 VRK2 SMTNL1 SMTNL1 RPS6KA5 RPS6KA5 MAPK10 MAPK10 TAF1L TAF1L MARK3 MARK3 HIPK1 HIPK1 IKBKE IKBKE AURKA AURKA SGK2 SGK2 CLK1 CLK1 CSNK2A1 CSNK2A1 MARK2 MARK2 CHEK2 CHEK2 MAPK12 MAPK12 ROCK2 ROCK2 CDK1 CDK1 IKBKB IKBKB MAP3K10 MAP3K10 TTC33 TTC33 IL24 IL24 MAPKAPK2 MAPKAPK2 EPO EPO DYRK1B DYRK1B PCK1 PCK1 PRKD1 PRKD1 MARK1 MARK1 RPS6KA1 RPS6KA1 NEK7 NEK7 CSNK1G1 CSNK1G1 DYRK4 DYRK4 PRKCQ PRKCQ CDK5 CDK5 MKNK1 MKNK1 SRC SRC MORC3 MORC3 AKT3 AKT3 PRKG2 PRKG2 UHMK1 UHMK1 LATS2 LATS2 PRKCZ PRKCZ NLK NLK WNK1 WNK1 DYRK1A DYRK1A PRKD2 PRKD2 PLK1 PLK1 DGKQ DGKQ CAMKV CAMKV PBK PBK CSNK2A2 CSNK2A2 LRRK2 LRRK2 TTBK1 TTBK1 LMTK2 LMTK2 PRKDC PRKDC ERN1 ERN1 PRKCE PRKCE STK4 STK4 MAPK1 MAPK1 TSSK4 TSSK4 PAK2 PAK2 TDGF1 TDGF1 STK39 STK39 CSNK1A1 CSNK1A1 GAS6 GAS6 SLC1A1 SLC1A1 STK32C STK32C HIPK2 HIPK2 DCLK2 DCLK2 MAPK9 MAPK9 RICTOR RICTOR TNKS TNKS CAMK1D CAMK1D PDPK1 PDPK1 F7B371_MACMU F7B371_MACMU MKNK2 MKNK2 TLK1 TLK1 TOP1 TOP1 PNCK PNCK MAPKAPK5 MAPKAPK5 MTOR MTOR NTRK2 NTRK2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1358 aa)
DCLK1Doublecortin like kinase 1. (759 aa)
TAF1Transcription initiation factor TFIID subunit. (1895 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase MLT isoform 1. (800 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PKN3Protein kinase N3. (889 aa)
TTBK2Tau-tubulin kinase 2. (1244 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CAB39Calcium-binding protein 39. (341 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (822 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
NEK6NIMA related kinase 6; Belongs to the protein kinase superfamily. (397 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (937 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (512 aa)
CSNK1A1LCasein kinase I isoform alpha-like protein; Belongs to the protein kinase superfamily. (337 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
VRK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (345 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4298 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (441 aa)
HIPK4Homeodomain interacting protein kinase 4. (616 aa)
VRK3VRK serine/threonine kinase 3. (482 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
PRKCDProtein kinase C. (729 aa)
STK38LNon-specific serine/threonine protein kinase. (512 aa)
SBK1SH3 domain binding kinase 1. (491 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1049 aa)
STK32ASerine/threonine kinase 32A; Belongs to the protein kinase superfamily. (407 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
MAST1Microtubule associated serine/threonine kinase 1. (1570 aa)
PKN2Protein kinase N2. (981 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (581 aa)
PKN1Protein kinase N1. (1013 aa)
MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (821 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
TLK2Tousled like kinase 2. (749 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
ENSMMUP00000059946Protein kinase domain-containing protein. (224 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAST4Microtubule associated serine/threonine kinase family member 4. (2655 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (473 aa)
MAST2Microtubule associated serine/threonine kinase 2. (1866 aa)
HIPK3Homeodomain-interacting protein kinase 3 isoform 1. (1215 aa)
SYKTyrosine-protein kinase. (635 aa)
PRKXUncharacterized protein; Belongs to the protein kinase superfamily. (358 aa)
LOC114675515Uncharacterized protein. (152 aa)
CDC7Cell division cycle 7-related protein kinase. (574 aa)
MASTLMicrotubule associated serine/threonine kinase like. (885 aa)
LOC106992273Serine/threonine-protein kinase PRKX; Belongs to the protein kinase superfamily. (358 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3660 aa)
SRPK2SRSF protein kinase 2. (920 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
CAMK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (494 aa)
DCLK3Doublecortin like kinase 3. (648 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2. (601 aa)
BAK1Uncharacterized protein. (261 aa)
MAST3Microtubule associated serine/threonine kinase 3. (1470 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2110 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
LATS1Large tumor suppressor kinase 1. (1224 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
RPS6KA3Ribosomal protein S6 kinase. (755 aa)
CAMK2DProtein kinase domain-containing protein. (687 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (550 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1025 aa)
RPS6KA6Ribosomal protein S6 kinase. (860 aa)
STK32BSerine/threonine kinase 32B; Belongs to the protein kinase superfamily. (414 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
TSSK6Testis-specific serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (273 aa)
MAPK13Mitogen-activated protein kinase. (386 aa)
BRSK1Serine/threonine-protein kinase BRSK1. (778 aa)
CLSPNClaspin. (1342 aa)
BRSK2BR serine/threonine kinase 2. (721 aa)
ULK3Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (477 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1614 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
VRK2VRK serine/threonine kinase 2. (507 aa)
SMTNL1Smoothelin like 1. (512 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
TAF1LTATA-box binding protein associated factor 1 like. (1776 aa)
MARK3Non-specific serine/threonine protein kinase. (889 aa)
HIPK1Uncharacterized protein. (1598 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (716 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (427 aa)
CLK1CDC like kinase 1. (596 aa)
CSNK2A1Casein kinase II subunit alpha isoform a; Belongs to the protein kinase superfamily. (391 aa)
MARK2Non-specific serine/threonine protein kinase. (788 aa)
CHEK2Checkpoint kinase 2. (539 aa)
MAPK12Mitogen-activated protein kinase. (479 aa)
ROCK2Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (952 aa)
TTC33Non-specific serine/threonine protein kinase. (581 aa)
IL24Interleukin 24. (207 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (409 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (193 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (640 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
MARK1Non-specific serine/threonine protein kinase. (795 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
NEK7Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (381 aa)
CSNK1G1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (475 aa)
DYRK4Dual specificity tyrosine phosphorylation regulated kinase 4. (635 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (739 aa)
CDK5Cyclin dependent kinase 5. (364 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (467 aa)
SRCTyrosine-protein kinase. (644 aa)
MORC3MORC family CW-type zinc finger 3. (940 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRKG2cGMP-dependent protein kinase. (781 aa)
UHMK1Serine/threonine-protein kinase Kist isoform 1. (419 aa)
LATS2Non-specific serine/threonine protein kinase. (1086 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
WNK1WNK lysine deficient protein kinase 1. (2844 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (763 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
DGKQDiacylglycerol kinase. (953 aa)
CAMKVCaM kinase-like vesicle-associated protein. (501 aa)
PBKPDZ binding kinase. (323 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (350 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
TTBK1Tau tubulin kinase 1. (1433 aa)
LMTK2Lemur tyrosine kinase 2. (1501 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
TSSK4Testis specific serine kinase 4. (338 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (182 aa)
STK39Serine/threonine kinase 39. (550 aa)
CSNK1A1Casein kinase I isoform alpha isoform 1; Belongs to the protein kinase superfamily. (365 aa)
GAS6Growth arrest specific 6. (684 aa)
SLC1A1Excitatory amino acid transporter 3. (524 aa)
STK32CSerine/threonine kinase 32C; Belongs to the protein kinase superfamily. (485 aa)
HIPK2Homeodomain interacting protein kinase 2. (1212 aa)
DCLK2Doublecortin like kinase 2. (783 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
CAMK1DCalcium/calmodulin-dependent protein kinase type 1D isoform 2; Belongs to the protein kinase superfamily. (385 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
F7B371_MACMUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (313 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2; Belongs to the protein kinase superfamily. (465 aa)
TLK1Serine/threonine-protein kinase tousled-like 1 isoform 1. (766 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)
PNCKPregnancy up-regulated nonubiquitous CaM kinase; Belongs to the protein kinase superfamily. (343 aa)
MAPKAPK5MAP kinase-activated protein kinase 5 isoform 1. (471 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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