(58 nodes) SCF ubiquitin ligase complex network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FBXO42	F-box only protein 42. (716 aa)
	CACYBP	Calcyclin-binding protein isoform 1. (228 aa)
	FBXL21P	F-box domain-containing protein. (434 aa)
	FBXO4	F-box protein 4. (490 aa)
	FBXO7	F-box only protein 7 isoform 1. (522 aa)
	FBXO33	F-box protein 33. (552 aa)
	FBXL6	F-box and leucine rich repeat protein 6. (535 aa)
	FBXL12	F-box and leucine-rich repeat protein 12. (326 aa)
	FBXL5	F-box and leucine rich repeat protein 5. (765 aa)
	FBXO39	F-box protein 39. (440 aa)
	FBXW5	F-box and WD repeat domain containing 5. (566 aa)
	FBXL22	F-box and leucine rich repeat protein 22. (226 aa)
	FBXL13	F-box and leucine rich repeat protein 13. (690 aa)
	FBXL17	F-box and leucine rich repeat protein 17. (702 aa)
	FBXL7	F-box/LRR-repeat protein 7. (491 aa)
	FBXL16	F-box and leucine rich repeat protein 16. (479 aa)
	FBXL3	F-box and leucine-rich repeat protein 3A. (428 aa)
	USP47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
	FBXO15	F-box protein 15. (596 aa)
	FBXO32	F-box only protein 32 isoform 1. (355 aa)
	FBXO17	F-box protein 27. (561 aa)
	FBXO44	F-box only protein 44 isoform 1. (255 aa)
	FBXW7	F-box/WD repeat-containing protein 7 isoform 1. (707 aa)
	FBXO9	F-box domain-containing protein. (447 aa)
	SPSB2	SplA/ryanodine receptor domain and SOCS box containing 2. (261 aa)
	FBXW11	Uncharacterized protein. (563 aa)
	BTRC	Uncharacterized protein. (629 aa)
	SKP1-2	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	RBX1	E3 ubiquitin-protein ligase RBX1. (108 aa)
	FBXL19	Uncharacterized protein. (715 aa)
	SKP2	S-phase kinase-associated protein 2 isoform 1. (424 aa)
	FBXO31	F-box domain-containing protein. (639 aa)
	SPSB1	SplA/ryanodine receptor domain and SOCS box containing 1. (273 aa)
	FBXL2	F-box and leucine rich repeat protein 2. (423 aa)
	SPSB4	SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa)
	FBXO45	Uncharacterized protein. (286 aa)
	FBXO25	F-box only protein 25 isoform 1. (367 aa)
	FBXL4	F-box and leucine rich repeat protein 4. (621 aa)
	FBXL14	F-box and leucine rich repeat protein 14. (428 aa)
	FBXL15	F-box domain-containing protein. (361 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (809 aa)
	FBXL8	F-box domain-containing protein. (386 aa)
	FBXO48	F-box domain-containing protein. (155 aa)
	AMN1	Antagonist of mitotic exit network 1 homolog. (402 aa)
	FBXO38	F-box only protein 38 isoform b. (1188 aa)
	FBXO6	F-box protein 6. (428 aa)
	NCCRP1	Non-specific cytotoxic cell receptor protein 1 homolog (zebrafish). (275 aa)
	FBXL20	F-box and leucine rich repeat protein 20. (448 aa)
	FBXW8	F-box and WD repeat domain containing 8. (598 aa)
	SPSB3	Uncharacterized protein. (382 aa)
	LRRC29	Leucine rich repeat containing 29. (278 aa)
	FBXO2	F-box protein 2. (327 aa)
	FBH1	F-box DNA helicase 1. (1088 aa)
	FBXW4	F-box and WD repeat domain containing 4. (591 aa)
	CKS1B	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	GSE1	Gse1 coiled-coil protein. (1221 aa)
	CCNF	Cyclin F; Belongs to the cyclin family. (786 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMN1	CUL1	ENSMMUP00000070045	ENSMMUP00000065959	Antagonist of mitotic exit network 1 homolog.	Cullin 1; Belongs to the cullin family.	0.493
AMN1	RBX1	ENSMMUP00000070045	ENSMMUP00000056775	Antagonist of mitotic exit network 1 homolog.	E3 ubiquitin-protein ligase RBX1.	0.542
AMN1	SKP1-2	ENSMMUP00000070045	ENSMMUP00000054213	Antagonist of mitotic exit network 1 homolog.	Uncharacterized protein; Belongs to the SKP1 family.	0.696
BTRC	CCNF	ENSMMUP00000050351	ENSMMUP00000080054	Uncharacterized protein.	Cyclin F; Belongs to the cyclin family.	0.552
BTRC	CUL1	ENSMMUP00000050351	ENSMMUP00000065959	Uncharacterized protein.	Cullin 1; Belongs to the cullin family.	0.999
BTRC	FBXO2	ENSMMUP00000050351	ENSMMUP00000075515	Uncharacterized protein.	F-box protein 2.	0.942
BTRC	FBXO4	ENSMMUP00000050351	ENSMMUP00000005294	Uncharacterized protein.	F-box protein 4.	0.915
BTRC	FBXO6	ENSMMUP00000050351	ENSMMUP00000071511	Uncharacterized protein.	F-box protein 6.	0.459
BTRC	FBXW11	ENSMMUP00000050351	ENSMMUP00000049952	Uncharacterized protein.	Uncharacterized protein.	0.689
BTRC	FBXW7	ENSMMUP00000050351	ENSMMUP00000044580	Uncharacterized protein.	F-box/WD repeat-containing protein 7 isoform 1.	0.956
BTRC	FBXW8	ENSMMUP00000050351	ENSMMUP00000075076	Uncharacterized protein.	F-box and WD repeat domain containing 8.	0.431
BTRC	RBX1	ENSMMUP00000050351	ENSMMUP00000056775	Uncharacterized protein.	E3 ubiquitin-protein ligase RBX1.	0.996
BTRC	SKP1-2	ENSMMUP00000050351	ENSMMUP00000054213	Uncharacterized protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.999
BTRC	SKP2	ENSMMUP00000050351	ENSMMUP00000059687	Uncharacterized protein.	S-phase kinase-associated protein 2 isoform 1.	0.963
BTRC	USP47	ENSMMUP00000050351	ENSMMUP00000030105	Uncharacterized protein.	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family.	0.587
CACYBP	SKP1-2	ENSMMUP00000002100	ENSMMUP00000054213	Calcyclin-binding protein isoform 1.	Uncharacterized protein; Belongs to the SKP1 family.	0.974
CCNF	BTRC	ENSMMUP00000080054	ENSMMUP00000050351	Cyclin F; Belongs to the cyclin family.	Uncharacterized protein.	0.552
CCNF	CKS1B	ENSMMUP00000080054	ENSMMUP00000076944	Cyclin F; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.664
CCNF	CKS2	ENSMMUP00000080054	ENSMMUP00000080967	Cyclin F; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.740
CCNF	CUL1	ENSMMUP00000080054	ENSMMUP00000065959	Cyclin F; Belongs to the cyclin family.	Cullin 1; Belongs to the cullin family.	0.902