STRINGSTRING
NRCAM NRCAM CLDN19 CLDN19 FKBP1B FKBP1B NTRK2 NTRK2 MTOR MTOR DMRT1 DMRT1 PMP22 PMP22 RGS21 RGS21 CACNG4 CACNG4 SOD1 SOD1 CACNG5 CACNG5 GPR88 GPR88 NFASC NFASC SCN1B SCN1B KCNA1 KCNA1 P2RX3 P2RX3 P2RX4 P2RX4 CACNA1H CACNA1H SCN1A SCN1A GPER1 GPER1 S1PR1 S1PR1 CACNG8 CACNG8 GRIK2 GRIK2 CACNG2 CACNG2 CACNA1I CACNA1I CACNA1G CACNA1G PLEC PLEC CHRNA1 CHRNA1 CHRM3 CHRM3 SPTBN4 SPTBN4 F7H9V3_MACMU F7H9V3_MACMU SCN11A SCN11A SCN3A SCN3A KCNA2 KCNA2 SCN7A SCN7A MYH14 MYH14 SCN10A SCN10A SCN5A SCN5A GLRA1 GLRA1 KCNMB2 KCNMB2 CHRM5 CHRM5 OTOA OTOA CACNG3 CACNG3 CLCN1 CLCN1 CACNB4 CACNB4 P2RX1 P2RX1 CNTNAP1 CNTNAP1 CACNG7 CACNG7 CHRNB4 CHRNB4 JAM3 JAM3 GJD2 GJD2 KCNMB3 KCNMB3 ANK3 ANK3 DRD5 DRD5 SCN2A SCN2A SCN4A SCN4A SCN8A SCN8A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRCAMNeuronal cell adhesion molecule. (1308 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
DMRT1DM domain-containing protein. (643 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
RGS21Regulator of G protein signaling 21. (152 aa)
CACNG4Uncharacterized protein. (657 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (161 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
GPR88G_PROTEIN_RECEP_F1_2 domain-containing protein. (384 aa)
NFASCNeurofascin. (1464 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (402 aa)
KCNA1Voltage-gated potassium channel subunit Kv1.1; Belongs to the potassium channel family. (495 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (468 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (467 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2352 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
GPER1G-protein coupled estrogen receptor 1; G-protein coupled estrogen receptor that binds to 17-beta- estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine [...] (375 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (387 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2111 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
PLECPlectin. (4862 aa)
CHRNA1Cholinergic receptor nicotinic alpha 1 subunit. (502 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
SPTBN4Spectrin beta chain, brain 3 isoform sigma5. (678 aa)
F7H9V3_MACMUUncharacterized protein. (584 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1790 aa)
SCN3ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2000 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2 isoform a; Belongs to the potassium channel family. (499 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1977 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2035 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1956 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
GLRA1Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (449 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (268 aa)
CHRM5Muscarinic acetylcholine receptor M5; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily. (532 aa)
OTOAOtoancorin. (1139 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
CLCN1Chloride channel protein. (1081 aa)
CACNB4SH3 domain-containing protein. (520 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
CNTNAP1Uncharacterized protein. (1382 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (492 aa)
JAM3Junctional adhesion molecule 3. (458 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (321 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (283 aa)
ANK3Ankyrin 3. (4375 aa)
DRD5D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (478 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1836 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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