STRINGSTRING
TPT1 TPT1 LIF LIF MED12 MED12 MMP24 MMP24 TET1 TET1 BRAF BRAF STAT3 STAT3 ASPM ASPM ASCL2 ASCL2 MED27 MED27 PELO PELO LEO1 LEO1 FNTA FNTA DLL1 DLL1 SRRT SRRT NIPBL NIPBL NODAL NODAL SIX2 SIX2 SFRP1 SFRP1 FOXO1 FOXO1 EIF4ENIF1 EIF4ENIF1 MED15 MED15 LRP5 LRP5 GATA2 GATA2 KDM4C KDM4C NANOG NANOG FZD7 FZD7 PIWIL2 PIWIL2 MED14 MED14 MED21 MED21 YAP1 YAP1 SALL4 SALL4 TRIM8 TRIM8 ZHX2 ZHX2 NOG NOG FAXC FAXC SMC3 SMC3 NANOS2 NANOS2 SMC5 SMC5 SMC1A SMC1A LDB1 LDB1 SKI SKI MED7 MED7 EIF4E EIF4E CTR9 CTR9 IGF2BP1 IGF2BP1 GNL3 GNL3 SOX4 SOX4 METTL3 METTL3 DIS3L2 DIS3L2 CDH2 CDH2 RTF1 RTF1 ESRRB ESRRB BCL9 BCL9 MTF2 MTF2 REST REST NOTCH1 NOTCH1 TUT4 TUT4 ZIC3 ZIC3 JAG1 JAG1 WNT7A WNT7A KLF10 KLF10 CUL4A CUL4A BMPR1A BMPR1A TBX3 TBX3 CDX2 CDX2 FGF4 FGF4 PRDM14 PRDM14 LOC100426235 LOC100426235 KLF4 KLF4 PCM1 PCM1 PADI4 PADI4 SOX9 SOX9 CDC73 CDC73 EOMES EOMES LDB2 LDB2 ZNF358 ZNF358 WNT9B WNT9B MCPH1 MCPH1 NR2E1 NR2E1 SETD6 SETD6 LIG4 LIG4 METTL14 METTL14 PROX1 PROX1 ZFP36L2 ZFP36L2 DDX6 DDX6 FANCC FANCC TCF15 TCF15 RIF1 RIF1 VPS72 VPS72 CTNNB1 CTNNB1 HES5 HES5 KIT KIT PRRX1 PRRX1 FANCD2 FANCD2 PHF19 PHF19 SS18 SS18 MED30 MED30 BCL9L BCL9L HESX1 HESX1 FGF10 FGF10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TPT1TCTP domain-containing protein; Belongs to the TCTP family. (196 aa)
LIFLIF interleukin 6 family cytokine. (206 aa)
MED12Mediator complex subunit 12. (2178 aa)
MMP24Matrix metallopeptidase 24. (644 aa)
TET1Tet methylcytosine dioxygenase 1. (2132 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
STAT3Signal transducer and activator of transcription. (871 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3476 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
MED27Mediator of RNA polymerase II transcription subunit 27. (311 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
LEO1RNA polymerase-associated protein LEO1. (666 aa)
FNTAHook microtubule tethering protein 3. (935 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
SRRTSerrate RNA effector molecule homolog isoform a. (876 aa)
NIPBLNipped-B protein. (2804 aa)
NODALNodal growth differentiation factor. (347 aa)
SIX2SIX homeobox 2. (292 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
FOXO1Forkhead box O1. (655 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (1121 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (788 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
GATA2GATA binding protein 2. (480 aa)
KDM4CLysine demethylase 4C. (1090 aa)
NANOGNanog homeobox. (305 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (597 aa)
PIWIL2Piwi like-2 protein; Belongs to the argonaute family. (973 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1454 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (208 aa)
YAP1Yes associated protein 1. (508 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
TRIM8Putative E3 ubiquitin-protein ligase TRIM8. (551 aa)
ZHX2Zinc fingers and homeoboxes protein 2. (837 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FAXCUncharacterized protein. (409 aa)
SMC3Structural maintenance of chromosomes protein. (1196 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
SMC5SMC_N domain-containing protein. (1201 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
LDB1LIM domain-binding protein 1 isoform 1. (411 aa)
SKISKI proto-oncogene. (730 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (232 aa)
EIF4EUncharacterized protein. (247 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
IGF2BP1Uncharacterized protein. (577 aa)
GNL3Guanine nucleotide-binding protein-like 3 isoform 1. (549 aa)
SOX4Transcription factor SOX. (467 aa)
METTL3N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (580 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (930 aa)
CDH2Cadherin-2 preproprotein; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (711 aa)
ESRRBEstrogen related receptor beta. (438 aa)
BCL9B-cell CLL/lymphoma 9 protein. (1426 aa)
MTF2Metal-response element-binding transcription factor 2 isoform a. (593 aa)
RESTRE1 silencing transcription factor. (1095 aa)
NOTCH1Notch receptor 1. (2556 aa)
TUT4Terminal uridylyl transferase 4. (1628 aa)
ZIC3Zic family member 3. (466 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
KLF10Transforming growth factor-beta-inducible early growth response protein 1. (480 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TBX3T-box transcription factor 3. (743 aa)
CDX2Caudal-type homeobox protein 2. (313 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
PRDM14PR domain-containing protein 14. (571 aa)
LOC100426235Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (252 aa)
KLF4Kruppel like factor 4. (544 aa)
PCM1Pericentriolar material 1. (2190 aa)
PADI4Peptidyl arginine deiminase 4. (663 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
CDC73Parafibromin. (531 aa)
EOMESEomesodermin. (703 aa)
LDB2LID domain-containing protein. (374 aa)
ZNF358Zinc finger protein 358. (575 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
MCPH1Uncharacterized protein. (864 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (390 aa)
SETD6SET domain containing 6, protein lysine methyltransferase. (610 aa)
LIG4DNA ligase. (911 aa)
METTL14Methyltransferase-like protein 14; Belongs to the MT-A70-like family. (456 aa)
PROX1Prospero homeobox protein 1. (737 aa)
ZFP36L2Zinc finger protein 36, C3H1 type-like 2. (492 aa)
DDX6Putative ATP-dependent RNA helicase DDX6; Belongs to the DEAD box helicase family. (483 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (578 aa)
TCF15BHLH domain-containing protein. (197 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
VPS72Vacuolar protein sorting-associated protein 72 homolog. (364 aa)
CTNNB1Catenin beta-1. (781 aa)
HES5Uncharacterized protein. (166 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
PRRX1Uncharacterized protein. (245 aa)
FANCD2Uncharacterized protein. (1471 aa)
PHF19PHD finger protein 19. (599 aa)
SS18Protein SSXT isoform 1. (418 aa)
MED30Mediator of RNA polymerase II transcription subunit 30. (178 aa)
BCL9LBCL9 like. (1500 aa)
HESX1HESX homeobox 1. (185 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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