STRINGSTRING
ANGPTL3 ANGPTL3 ABI2 ABI2 PLCE1 PLCE1 RDX RDX ABI3 ABI3 PLXND1 PLXND1 FAP FAP ITGB3 ITGB3 PTPN13 PTPN13 CIB3 CIB3 CD44 CD44 DAG1 DAG1 SRCIN1 SRCIN1 ABI1 ABI1 PIK3CA PIK3CA PIP5K1A PIP5K1A AVIL AVIL UNC5C UNC5C ARPC3 ARPC3 ACTC1 ACTC1 CARMIL3 CARMIL3 SHTN1 SHTN1 ILK ILK DPP4 DPP4 PKD2 PKD2 MYO1G MYO1G PDLIM4 PDLIM4 TSC1 TSC1 NF2 NF2 INPPL1 INPPL1 HAX1 HAX1 RAC3 RAC3 IGF2BP1 IGF2BP1 WASL WASL PABPC1 PABPC1 MYO9B MYO9B CDH1 CDH1 ARHGAP31 ARHGAP31 DMD DMD FLOT2 FLOT2 APBB2 APBB2 GSN GSN MCC MCC ARHGEF7 ARHGEF7 ARHGEF6 ARHGEF6 SNX1 SNX1 FLOT1 FLOT1 DNM2 DNM2 KPTN KPTN MYLK MYLK SSH1 SSH1 FSCN3 FSCN3 CSPG4 CSPG4 TESK1 TESK1 SCYL3 SCYL3 VIL1 VIL1 KLHL2 KLHL2 TESC TESC ACTG2 ACTG2 ACTA2 ACTA2 ITGB1 ITGB1 MEFV MEFV CTNNA1 CTNNA1 FGD5 FGD5 PAK1 PAK1 PTK2B PTK2B PHACTR4 PHACTR4 ITGAV ITGAV PPP1R9B PPP1R9B PLEKHG5 PLEKHG5 PTPRO PTPRO CDK5 CDK5 CD177 CD177 RAC1 RAC1 CLRN1 CLRN1 CAPRIN1 CAPRIN1 ABLIM3 ABLIM3 ACTA1 ACTA1 ABLIM1 ABLIM1 ARPC2 ARPC2 DBN1 DBN1 SNX2 SNX2 VASP VASP LIMK1 LIMK1 F6QAX2_MACMU F6QAX2_MACMU TIAM2 TIAM2 FGD2 FGD2 FAT1 FAT1 SH3RF1 SH3RF1 PALLD PALLD MYO10 MYO10 CORO6 CORO6 LOC716527 LOC716527 FSCN1 FSCN1 CTNNA3 CTNNA3 ANTXR1 ANTXR1 PLEKHH2 PLEKHH2 CTNND1 CTNND1 FAM89B FAM89B CORO1B CORO1B DOCK8 DOCK8 CDC42 CDC42 AMOT AMOT NHS NHS FERMT2 FERMT2 NEDD9 NEDD9 ITSN1 ITSN1 FGD1 FGD1 SRGAP2 SRGAP2 BRK1 BRK1 STX2 STX2 SPATA13 SPATA13 RHOA RHOA CIB1 CIB1 ACTN1 ACTN1 SCRIB SCRIB PDPN PDPN DBNL DBNL ROCK1 ROCK1 PSTPIP1 PSTPIP1 LOC719690 LOC719690 NRBP1 NRBP1 ARAP3 ARAP3 CARMIL2 CARMIL2 MTSS2 MTSS2 PKN2 PKN2 ENSMMUP00000053227 ENSMMUP00000053227 DPYSL3 DPYSL3 PARVA PARVA BAIAP2 BAIAP2 SLC9A1 SLC9A1 FGD4 FGD4 APC2 APC2 DUSP22 DUSP22 RAC2 RAC2 DGKZ DGKZ RAPGEF3 RAPGEF3 PLCG1 PLCG1 PTPRM PTPRM TRPV4 TRPV4 GIT1 GIT1 CFL1 CFL1 PXN PXN AJUBA AJUBA CTTN CTTN PLEK2 PLEK2 RAPH1 RAPH1 AP3S2 AP3S2 CCDC88A CCDC88A CORO1A CORO1A P4HB P4HB EVL EVL SPEF1 SPEF1 AKT1 AKT1 CORO1C CORO1C WASF1 WASF1 PODXL PODXL WASF3 WASF3 CTNNB1 CTNNB1 SORBS2 SORBS2 SLC39A6 SLC39A6 CARMIL1 CARMIL1 NCKAP1 NCKAP1 IQGAP2 IQGAP2 LOC114675467 LOC114675467 MYH10 MYH10 TWF2 TWF2 BCAR1 BCAR1 GDPD2 GDPD2 CAPG CAPG PIEZO1 PIEZO1 SYNE2 SYNE2 ENSMMUP00000069310 ENSMMUP00000069310 ABITRAM ABITRAM APC APC APBB1IP APBB1IP ENSMMUP00000071548 ENSMMUP00000071548 ACTR3 ACTR3 PARVB PARVB ENAH ENAH ENSMMUP00000072813 ENSMMUP00000072813 CDC42BPA CDC42BPA RAB3IP RAB3IP STX3 STX3 ARPC5 ARPC5 AIF1 AIF1 LOC721299 LOC721299 STMN2 STMN2 WASF2 WASF2 FGD6 FGD6 RAB13 RAB13 ENSMMUP00000077229 ENSMMUP00000077229 ALS2 ALS2 CYFIP1 CYFIP1 APBB1 APBB1 CDC42BPB CDC42BPB ITGB1BP1 ITGB1BP1 KITLG KITLG EPHA2 EPHA2 CTTNBP2NL CTTNBP2NL STX4 STX4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANGPTL3Angiopoietin like 3. (476 aa)
ABI2Abl interactor 2. (549 aa)
PLCE1Phosphoinositide phospholipase C. (2317 aa)
RDXRadixin. (604 aa)
ABI3ABI family member 3. (366 aa)
PLXND1Plexin D1. (1925 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
PTPN13Protein tyrosine phosphatase non-receptor type 13. (2492 aa)
CIB3Kinase-interacting protein 3. (187 aa)
CD44Phagocytic glycoprotein I. (742 aa)
DAG1Dystroglycan preproprotein. (894 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1533 aa)
ABI1Abl interactor 1 isoform a. (508 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type-1 alpha isoform 1. (561 aa)
AVILAdvillin. (819 aa)
UNC5CUnc-5 netrin receptor C. (931 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
CARMIL3Capping protein regulator and myosin 1 linker 3. (1370 aa)
SHTN1Shootin 1. (676 aa)
ILKIntegrin-linked protein kinase. (452 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (766 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (969 aa)
MYO1GMyosin IG; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1144 aa)
PDLIM4PDZ and LIM domain protein 4 isoform 1. (330 aa)
TSC1TSC complex subunit 1. (1164 aa)
NF2Merlin isoform 1. (595 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1315 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
IGF2BP1Uncharacterized protein. (577 aa)
WASLNeural Wiskott-Aldrich syndrome protein. (505 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (638 aa)
MYO9BUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2115 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
ARHGAP31Rho GTPase activating protein 31. (1442 aa)
DMDUncharacterized protein. (3685 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
APBB2Amyloid beta precursor protein binding family B member 2. (768 aa)
GSNGelsolin. (809 aa)
MCCMCC regulator of WNT signaling pathway. (1014 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (775 aa)
SNX1Uncharacterized protein. (534 aa)
FLOT1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (439 aa)
DNM2Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
KPTNKaptin, actin binding protein. (525 aa)
MYLKMyosin light chain kinase. (1914 aa)
SSH1Slingshot protein phosphatase 1. (1066 aa)
FSCN3Fascin. (498 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2322 aa)
TESK1Dual specificity testis-specific protein kinase 1. (626 aa)
SCYL3SCY1 like pseudokinase 3. (736 aa)
VIL1Villin 1. (827 aa)
KLHL2Kelch like family member 2. (596 aa)
TESCTescalcin isoform 1. (214 aa)
ACTG2Actin gamma 2, smooth muscle. (376 aa)
ACTA2Uncharacterized protein. (396 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MEFVMEFV innate immuity regulator, pyrin. (786 aa)
CTNNA1Uncharacterized protein. (906 aa)
FGD5FYVE, RhoGEF and PH domain containing 5. (1499 aa)
PAK1Non-specific serine/threonine protein kinase. (575 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
PHACTR4Phosphatase and actin regulator. (817 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (818 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1155 aa)
PTPROUncharacterized protein. (1216 aa)
CDK5Cyclin dependent kinase 5. (364 aa)
CD177CD177 molecule. (424 aa)
RAC1Uncharacterized protein. (212 aa)
CLRN1Clarin 1. (245 aa)
CAPRIN1Cell cycle associated protein 1. (709 aa)
ABLIM3Actin binding LIM protein family member 3. (684 aa)
ACTA1Actin alpha 1, skeletal muscle. (377 aa)
ABLIM1Actin binding LIM protein 1. (822 aa)
ARPC2Actin related protein 2/3 complex subunit 2. (603 aa)
DBN1Drebrin 1. (695 aa)
SNX2Sorting nexin 2. (526 aa)
VASPVasodilator stimulated phosphoprotein. (428 aa)
LIMK1LIM domain kinase 1 isoform 1. (647 aa)
F6QAX2_MACMUTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1701 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (655 aa)
FAT1FAT atypical cadherin 1. (4643 aa)
SH3RF1SH3 domain containing ring finger 1. (888 aa)
PALLDPalladin, cytoskeletal associated protein. (1400 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2058 aa)
CORO6Coronin; Belongs to the WD repeat coronin family. (472 aa)
LOC716527Flotillin-2. (428 aa)
FSCN1Fascin. (493 aa)
CTNNA3Catenin alpha-3. (895 aa)
ANTXR1ANTXR cell adhesion molecule 1. (583 aa)
PLEKHH2Pleckstrin homology, MyTH4 and FERM domain containing H2. (1493 aa)
CTNND1Uncharacterized protein. (968 aa)
FAM89BUncharacterized protein. (176 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (513 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (2082 aa)
CDC42Cell division control protein 42 homolog isoform 1. (191 aa)
AMOTAngiomotin. (1099 aa)
NHSNHS actin remodeling regulator. (1631 aa)
FERMT2PH domain-containing protein. (698 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
ITSN1Intersectin 1. (1720 aa)
FGD1FYVE, RhoGEF and PH domain-containing protein 1. (961 aa)
SRGAP2SLIT-ROBO Rho GTPase-activating protein 2 isoform a. (1071 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
STX2Syntaxin-2 isoform 2; Belongs to the syntaxin family. (288 aa)
SPATA13Uncharacterized protein. (1330 aa)
RHOARas homolog family member A. (209 aa)
CIB1Calcium and integrin-binding protein 1. (191 aa)
ACTN1Actinin alpha 1. (914 aa)
SCRIBScribble planar cell polarity protein. (1451 aa)
PDPNPodoplanin. (162 aa)
DBNLUncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (536 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
PSTPIP1Proline-serine-threonine phosphatase interacting protein 1. (492 aa)
LOC719690Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1284 aa)
NRBP1Nuclear receptor binding protein 1. (543 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1546 aa)
CARMIL2Capping protein regulator and myosin 1 linker 2. (1436 aa)
MTSS2MTSS I-BAR domain containing 2. (849 aa)
PKN2Protein kinase N2. (981 aa)
ENSMMUP00000053227Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (170 aa)
DPYSL3Dihydropyrimidinase like 3. (684 aa)
PARVAParvin alpha. (372 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 4. (534 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
FGD4FYVE, RhoGEF and PH domain containing 4. (931 aa)
APC2APC regulator of WNT signaling pathway 2. (2403 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (279 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
DGKZDiacylglycerol kinase. (1118 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1465 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (963 aa)
GIT1GIT ArfGAP 1. (794 aa)
CFL1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (177 aa)
PXNPaxillin. (1167 aa)
AJUBAAjuba LIM protein. (538 aa)
CTTNSH3 domain-containing protein. (566 aa)
PLEK2Pleckstrin 2. (353 aa)
RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1309 aa)
AP3S2Clat_adaptor_s domain-containing protein. (394 aa)
CCDC88ACoiled-coil domain containing 88A. (1999 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
P4HBProtein disulfide-isomerase. (510 aa)
EVLEnah/Vasp-like. (469 aa)
SPEF1Sperm flagellar protein 1. (236 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (527 aa)
WASF1Wiskott-Aldrich syndrome protein family member 1. (559 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (522 aa)
WASF3Wiskott-Aldrich syndrome protein family member 3. (502 aa)
CTNNB1Catenin beta-1. (781 aa)
SORBS2Sorbin and SH3 domain containing 2. (1246 aa)
SLC39A6Solute carrier family 39 member 6. (784 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1430 aa)
NCKAP1Nck-associated protein 1 isoform 2. (1134 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1596 aa)
LOC114675467Calponin-homology (CH) domain-containing protein. (341 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
TWF2Twinfilin actin binding protein 2. (480 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (935 aa)
GDPD2Glycerophosphodiester phosphodiesterase domain containing 2. (642 aa)
CAPGCapping actin protein, gelsolin like. (446 aa)
PIEZO1Piezo-type mechanosensitive ion channel component. (2525 aa)
SYNE2Spectrin repeat containing nuclear envelope protein 2. (6909 aa)
ENSMMUP00000069310Uncharacterized protein. (106 aa)
ABITRAMUncharacterized protein. (180 aa)
APCAPC regulator of WNT signaling pathway. (2871 aa)
APBB1IPAmyloid beta precursor protein binding family B member 1 interacting protein. (674 aa)
ENSMMUP00000071548PIPK domain-containing protein. (534 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
PARVBParvin beta. (406 aa)
ENAHENAH actin regulator. (805 aa)
ENSMMUP00000072813Uncharacterized protein. (116 aa)
CDC42BPANon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1845 aa)
RAB3IPRAB3A interacting protein. (481 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (338 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (184 aa)
AIF1Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). (147 aa)
LOC721299Uncharacterized protein; Belongs to the actin family. (372 aa)
STMN2Stathmin; Belongs to the stathmin family. (179 aa)
WASF2WASP family member 2. (498 aa)
FGD6FYVE, RhoGEF and PH domain containing 6. (1431 aa)
RAB13Uncharacterized protein. (245 aa)
ENSMMUP00000077229Death domain-containing protein. (154 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1657 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
APBB1Amyloid beta precursor protein binding family B member 1. (838 aa)
CDC42BPBCDC42 binding protein kinase beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1728 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (279 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (283 aa)
EPHA2EPH receptor A2. (1033 aa)
CTTNBP2NLCTTNBP2 N-terminal like. (658 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (322 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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