STRINGSTRING
RC3H1 RC3H1 RABL3 RABL3 FZD8 FZD8 CCR7 CCR7 TRAF3IP2 TRAF3IP2 FOXP1 FOXP1 IL4 IL4 PIK3R2 PIK3R2 LEPR LEPR STAT5B STAT5B CD8A CD8A BATF BATF LEP LEP CCR6 CCR6 PSMB11 PSMB11 GATA3 GATA3 DNAJA3 DNAJA3 SOX13 SOX13 FOXP3 FOXP3 TP53 TP53 CDK6 CDK6 CD74 CD74 IL18R1 IL18R1 PKNOX1 PKNOX1 TSC1 TSC1 TOX TOX ITK ITK CHD7 CHD7 RORC RORC GPR183 GPR183 NCAPH2 NCAPH2 LMBR1L LMBR1L ATP7A ATP7A ADAM17 ADAM17 LOC712274 LOC712274 CLEC4D CLEC4D CLEC4E CLEC4E RELB RELB NRARP NRARP SOX4 SOX4 THEMIS THEMIS PRKDC PRKDC WNT1 WNT1 PPP3CB PPP3CB RSAD2 RSAD2 LFNG LFNG SPN SPN PTGER4 PTGER4 F7HDN1_MACMU F7HDN1_MACMU CD3D CD3D IL2RG IL2RG RAG2 RAG2 NKX2-3 NKX2-3 IL15 IL15 GPR89A GPR89A ATG5 ATG5 ZAP70 ZAP70 SP3 SP3 FOXN1 FOXN1 STK11 STK11 IL6R IL6R TCIRG1 TCIRG1 CCR9 CCR9 TGFB1 TGFB1 ENTPD7 ENTPD7 RIPK2 RIPK2 SRF SRF TCF7 TCF7 IKZF3 IKZF3 PATZ1 PATZ1 ADA ADA LY9 LY9 SLAMF6 SLAMF6 SEMA4A SEMA4A ZBTB7B ZBTB7B CTSL CTSL PLA2G2D PLA2G2D FZD7 FZD7 STAT3 STAT3 LEF1 LEF1 LCK LCK BRAF BRAF ENSMMUP00000044881 ENSMMUP00000044881 RHOA RHOA IL7R IL7R IRF1 IRF1 RORA RORA ZFP36L1 ZFP36L1 ATF2 ATF2 IL6 IL6 FUT7 FUT7 IL7 IL7 PTPN22 PTPN22 ABL1 ABL1 PTPRC PTPRC PGBD4 PGBD4 ENSMMUP00000054262 ENSMMUP00000054262 ARMC5 ARMC5 GIMAP1 GIMAP1 LOC100428304 LOC100428304 ZBTB1 ZBTB1 TESPA1 TESPA1 JMJD6 JMJD6 WNT10B WNT10B RC3H2 RC3H2 VAV1 VAV1 PIK3R3 PIK3R3 TNFSF8 TNFSF8 KIT KIT CARD11 CARD11 FADD FADD STAT6 STAT6 IRF4 IRF4 CD3E CD3E TBX21 TBX21 CTNNB1 CTNNB1 GPR18 GPR18 SYK SYK IL21 IL21 ANXA1 ANXA1 ERBB2 ERBB2 CD28 CD28 SHH SHH DLL4 DLL4 PAX1 PAX1 PTPN2 PTPN2 PRR7 PRR7 GLI3 GLI3 WNT4 WNT4 ZFP36L2 ZFP36L2 PIK3CD PIK3CD XRCC4 XRCC4 LIG4 LIG4 CD4 CD4 BCL2 BCL2 CLEC4G CLEC4G RUNX2 RUNX2 ITPKB ITPKB CRACR2A CRACR2A EOMES EOMES AIRE AIRE CD83 CD83 ZFPM1 ZFPM1 MTOR MTOR RAG1 RAG1 LOC705334 LOC705334 TMEM98 TMEM98 JAG2 JAG2 DOCK2 DOCK2 B2M B2M EGR1 EGR1 BCL3 BCL3 HLX HLX FZD5 FZD5 PREX1 PREX1 RHOH RHOH BCL11B BCL11B BCL6 BCL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RC3H1Ring finger and CCCH-type domains 1. (1133 aa)
RABL3Uncharacterized protein. (268 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (693 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
TRAF3IP2SEFIR domain-containing protein. (572 aa)
FOXP1Fork-head domain-containing protein. (695 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
LEPRLeptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1163 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
CD8ACD8a molecule. (269 aa)
BATFBasic leucine zipper ATF-like transcription factor. (137 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (379 aa)
PSMB11Proteasome subunit beta. (243 aa)
GATA3GATA binding protein 3. (444 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
SOX13SRY-box 13. (621 aa)
FOXP3Forkhead box P3. (539 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (335 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform a. (294 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
PKNOX1PBX/knotted 1 homeobox 1. (503 aa)
TSC1TSC complex subunit 1. (1164 aa)
TOXThymocyte selection associated high mobility group box. (526 aa)
ITKTyrosine-protein kinase. (620 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7. (2998 aa)
RORCRAR related orphan receptor C. (518 aa)
GPR183G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (361 aa)
NCAPH2Condensin-2 complex subunit H2 isoform 2. (611 aa)
LMBR1LUncharacterized protein; Belongs to the LIMR family. (489 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17 preproprotein. (824 aa)
LOC71227440S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
CLEC4DC-type lectin domain family 4 member D. (215 aa)
CLEC4EC-type lectin domain family 4 member E. (274 aa)
RELBRELB proto-oncogene, NF-kB subunit. (574 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
SOX4Transcription factor SOX. (467 aa)
THEMISThymocyte selection associated. (680 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
RSAD2Radical S-adenosyl methionine domain-containing protein 2. (360 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase. (379 aa)
SPNSialophorin. (547 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (490 aa)
F7HDN1_MACMUIG domain-containing protein. (248 aa)
CD3DIg_4 domain-containing protein. (171 aa)
IL2RGCytokine receptor common subunit gamma. (369 aa)
RAG2Recombination activating 2. (532 aa)
NKX2-3NK2 homeobox 3. (364 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (162 aa)
GPR89AGolgi pH regulator B. (455 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (317 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
SP3Sp3 transcription factor. (796 aa)
FOXN1Forkhead box N1. (648 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa)
IL6RInterleukin 6 receptor. (536 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (853 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ENTPD7Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (604 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
SRFSerum response factor. (508 aa)
TCF7Transcription factor 7. (571 aa)
IKZF3Zinc finger protein Aiolos isoform 1. (509 aa)
PATZ1POZ/BTB and AT hook containing zinc finger 1. (687 aa)
ADAAdenosine deaminase. (390 aa)
LY9Uncharacterized protein. (208 aa)
SLAMF6SLAM family member 6. (339 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (760 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (636 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
PLA2G2DPhospholipase A(2). (161 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (597 aa)
STAT3Signal transducer and activator of transcription. (871 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
LCKTyrosine-protein kinase. (567 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
ENSMMUP00000044881A_deaminase domain-containing protein. (74 aa)
RHOARas homolog family member A. (209 aa)
IL7RInterleukin 7 receptor. (459 aa)
IRF1Interferon regulatory factor. (325 aa)
RORARAR related orphan receptor A. (555 aa)
ZFP36L1ZFP36 ring finger protein like 1. (344 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
FUT7Fucosyltransferase 7. (342 aa)
IL7Uncharacterized protein. (184 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (813 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
PGBD4PiggyBac transposable element derived 4. (583 aa)
ENSMMUP00000054262Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
ARMC5Armadillo repeat containing 5. (1030 aa)
GIMAP1AIG1-type G domain-containing protein. (306 aa)
LOC100428304AIG1-type G domain-containing protein. (274 aa)
ZBTB1Zinc finger and BTB domain containing 1. (771 aa)
TESPA1KRAP_IP3R_bind domain-containing protein. (521 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (436 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
RC3H2RING finger and CCCH-type zinc finger domain-containing protein 2 isoform 1. (1191 aa)
VAV1Vav guanine nucleotide exchange factor 1. (928 aa)
PIK3R3Uncharacterized protein. (507 aa)
TNFSF8Tumor necrosis factor ligand superfamily member 8; Belongs to the tumor necrosis factor family. (234 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
STAT6Signal transducer and activator of transcription. (902 aa)
IRF4Interferon regulatory factor 4 isoform 1. (451 aa)
CD3ECD3e molecule. (217 aa)
TBX21T-box transcription factor 21. (539 aa)
CTNNB1Catenin beta-1. (781 aa)
GPR18G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (300 aa)
SYKTyrosine-protein kinase. (635 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
ANXA1Annexin. (367 aa)
ERBB2Receptor protein-tyrosine kinase. (1437 aa)
CD28T-cell-specific surface glycoprotein CD28. (220 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
PAX1Paired box 1. (535 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
PRR7Proline rich 7, synaptic. (276 aa)
GLI3GLI family zinc finger 3. (1580 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ZFP36L2Zinc finger protein 36, C3H1 type-like 2. (492 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
LIG4DNA ligase. (911 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
RUNX2RUNX family transcription factor 2. (647 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (941 aa)
CRACR2ACalcium release activated channel regulator 2A. (731 aa)
EOMESEomesodermin. (703 aa)
AIREAutoimmune regulator. (614 aa)
CD83CD83 antigen isoform a. (205 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1024 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1081 aa)
LOC705334Uncharacterized protein. (205 aa)
TMEM98Transmembrane protein 98. (226 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1290 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1867 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (119 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
BCL3BCL3 transcription coactivator. (454 aa)
HLXH2.0 like homeobox. (495 aa)
FZD5Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1661 aa)
RHOHRho-related GTP-binding protein RhoH. (191 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
BCL6Uncharacterized protein. (735 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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