STRINGSTRING
SOX9 SOX9 TRPM4 TRPM4 RFLNA RFLNA SRGN SRGN SMAD6 SMAD6 MEF2C MEF2C LRP4 LRP4 ENPP1 ENPP1 SFRP1 SFRP1 TGFB1 TGFB1 LTBP3 LTBP3 KREMEN1 KREMEN1 PTK2B PTK2B AHSG AHSG NOTCH1 NOTCH1 GATA1 GATA1 CALCR CALCR CHSY1 CHSY1 DKK1 DKK1 VDR VDR GFRA4 GFRA4 TPH1 TPH1 BCOR BCOR KREMEN2 KREMEN2 HIF1A HIF1A MDK MDK ECM1 ECM1 CALCA CALCA SMAD7 SMAD7 RFLNB RFLNB FGF23 FGF23 BCL2 BCL2 SOST SOST CCR1 CCR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1215 aa)
RFLNAUncharacterized protein. (216 aa)
SRGNSerglycin. (153 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1905 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (925 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1185 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (492 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
AHSGAlpha 2-HS glycoprotein. (356 aa)
NOTCH1Notch receptor 1. (2556 aa)
GATA1GATA binding protein 1. (413 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (517 aa)
CHSY1Hexosyltransferase. (802 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
VDRVitamin D receptor. (477 aa)
GFRA4GDNF family receptor alpha 4. (287 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
BCORBCL6 corepressor. (1752 aa)
KREMEN2Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
MDKMidkine. (143 aa)
ECM1Extracellular matrix protein 1 isoform 1. (540 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
SMAD7Mothers against decapentaplegic homolog. (462 aa)
RFLNBRefilin B. (216 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
SOSTSclerostin. (213 aa)
CCR1C-C chemokine receptor type 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. (355 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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