STRINGSTRING
TMEM38B TMEM38B ITGA3 ITGA3 SLC23A1 SLC23A1 HEG1 HEG1 KRAS KRAS ADAMTS2 ADAMTS2 SFTPD SFTPD PKD1 PKD1 THRA THRA MAN2A1 MAN2A1 YAP1 YAP1 FNDC3B FNDC3B MMP12 MMP12 DAG1 DAG1 PDGFA PDGFA ASCL1 ASCL1 NOG NOG FGF2 FGF2 CLCN2 CLCN2 SPDEF SPDEF HHIP HHIP EXT1 EXT1 BMPR2 BMPR2 FGF7 FGF7 FGF9 FGF9 TGFBR2 TGFBR2 CTSH CTSH CCBE1 CCBE1 EIF4G1 EIF4G1 EIF4E EIF4E CRISPLD2 CRISPLD2 LAMA1 LAMA1 PDGFRB PDGFRB TBX5 TBX5 TGFB3 TGFB3 MAPK1 MAPK1 KDR KDR ATP7A ATP7A MYOCD MYOCD MMP14 MMP14 ABCA12 ABCA12 CTSZ CTSZ FGF8 FGF8 EDN2 EDN2 ABCA15 ABCA15 NOTCH1 NOTCH1 AGR2 AGR2 PPP1CA PPP1CA ZIC3 ZIC3 HIKESHI HIKESHI HOPX HOPX FLT4 FLT4 ACVR2B ACVR2B ABCA3 ABCA3 FGF18 FGF18 ELK1 ELK1 SMPD3 SMPD3 ALDH1A2 ALDH1A2 PKDCC PKDCC SLC7A11 SLC7A11 NOS3 NOS3 CELSR1 CELSR1 GRHL2 GRHL2 CRH CRH TTC25 TTC25 SP3 SP3 ESRP2 ESRP2 TIMELESS TIMELESS GLI1 GLI1 HMGCS2 HMGCS2 NODAL NODAL SEC24B SEC24B LTBP3 LTBP3 PHEX PHEX TGFB1 TGFB1 AARD AARD SRF SRF PTK7 PTK7 PHF14 PHF14 LOXL3 LOXL3 CREB1 CREB1 ADA ADA HMGB1-2 HMGB1-2 DPPA4 DPPA4 ADAMTSL2 ADAMTSL2 LHX3 LHX3 LOC114672301 LOC114672301 LOC114669852 LOC114669852 DNAAF1 DNAAF1 NKIRAS2 NKIRAS2 STRA6 STRA6 FBXW7 FBXW7 ENSMMUP00000044881 ENSMMUP00000044881 CCN2 CCN2 SMAD2 SMAD2 COL3A1 COL3A1 RCN3 RCN3 PDPN PDPN FGFR2 FGFR2 LTA4H LTA4H RDH10 RDH10 NFIB NFIB LIF LIF CCDC39 CCDC39 TBX2 TBX2 RBBP9 RBBP9 SREBF1 SREBF1 MAPK3 MAPK3 ITGB6 ITGB6 FGF10 FGF10 ASXL1 ASXL1 SAV1 SAV1 EPAS1 EPAS1 KLF2 KLF2 AP3B1 AP3B1 ENSMMUP00000056315 ENSMMUP00000056315 SOX11 SOX11 AIMP2 AIMP2 GLI2 GLI2 JMJD6 JMJD6 RC3H2 RC3H2 IGFBP5 IGFBP5 PPP3R1 PPP3R1 HPS1 HPS1 ENSMMUP00000061664 ENSMMUP00000061664 WNT11 WNT11 WNT2 WNT2 CTNNB1 CTNNB1 HMGB1 HMGB1 SPRY1 SPRY1 ENSMMUP00000063643 ENSMMUP00000063643 FOXF1 FOXF1 SHH SHH ENSMMUP00000065874 ENSMMUP00000065874 MAN1A2 MAN1A2 NKX2-1 NKX2-1 GLI3 GLI3 SPRY2 SPRY2 PROX1 PROX1 STK40 STK40 BAG6 BAG6 SMPD5 SMPD5 HOXA5 HOXA5 RSPO2 RSPO2 FOXA1 FOXA1 FOXJ1 FOXJ1 FGF1 FGF1 ZFPM2 ZFPM2 LOX LOX ATXN1L ATXN1L GATA6 GATA6 SIM2 SIM2 FBXW9 FBXW9 LIPA LIPA CHI3L1 CHI3L1 WNT5A WNT5A THRB THRB ARG1 ARG1 ENSMMUP00000075283 ENSMMUP00000075283 WNT7B WNT7B TCF21 TCF21 EP300 EP300 BMP4 BMP4 HS6ST1 HS6ST1 DLG5 DLG5 TBX4 TBX4 PLOD3 PLOD3 HSPB11 HSPB11 BMPR1A BMPR1A ENSMMUP00000079873 ENSMMUP00000079873 RIDA RIDA ERRFI1 ERRFI1 HSD11B1 HSD11B1 NKX2-8 NKX2-8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMEM38BTrimeric intracellular cation channel type B. (291 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
SLC23A1Solute carrier family 23 member 1. (602 aa)
HEG1Heart development protein with EGF like domains 1. (1486 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2. (1293 aa)
SFTPDPulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. (375 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4298 aa)
THRAThyroid hormone receptor alpha. (486 aa)
MAN2A1Alpha-mannosidase. (1143 aa)
YAP1Yes associated protein 1. (508 aa)
FNDC3BFibronectin type III domain containing 3B. (1206 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
DAG1Dystroglycan preproprotein. (894 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (249 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (238 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
CLCN2Chloride channel protein. (898 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
HHIPHedgehog-interacting protein. (700 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1 isoform 6. (1604 aa)
EIF4EUncharacterized protein. (247 aa)
CRISPLD2Cysteine rich secretory protein LCCL domain containing 2. (497 aa)
LAMA1Uncharacterized protein. (528 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
TBX5T-box transcription factor 5. (518 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
MYOCDMyocardin. (986 aa)
MMP14Matrix metalloproteinase-14 preproprotein. (582 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
EDN2Endothelin 2. (206 aa)
ABCA15Uncharacterized protein. (182 aa)
NOTCH1Notch receptor 1. (2556 aa)
AGR2Uncharacterized protein. (175 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (347 aa)
ZIC3Zic family member 3. (466 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
HOPXHOP homeobox. (109 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
ABCA3ATP binding cassette subfamily A member 3. (1704 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ELK1ETS domain-containing protein Elk-1. (428 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
ALDH1A2Retinal dehydrogenase 2 isoform 1; Belongs to the aldehyde dehydrogenase family. (518 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
SLC7A11Uncharacterized protein. (519 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (1818 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
CRHCorticotropin releasing hormone. (196 aa)
TTC25Tetratricopeptide repeat domain 25. (671 aa)
SP3Sp3 transcription factor. (796 aa)
ESRP2Epithelial splicing regulatory protein 2. (715 aa)
TIMELESSTimeless circadian regulator. (1204 aa)
GLI1Zinc finger protein GLI1 isoform 1. (1106 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
NODALNodal growth differentiation factor. (347 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1277 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1185 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (749 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
AARDAlanine and arginine rich domain containing protein. (155 aa)
SRFSerum response factor. (508 aa)
PTK7Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
PHF14PHD finger protein 14. (968 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
ADAAdenosine deaminase. (390 aa)
HMGB1-2High mobility group protein B1. (214 aa)
DPPA4Developmental pluripotency associated 4. (301 aa)
ADAMTSL2ADAMTS like 2. (958 aa)
LHX3LIM homeobox 3. (402 aa)
LOC114672301ETS domain-containing protein. (488 aa)
LOC114669852Uncharacterized protein. (328 aa)
DNAAF1Dynein assembly factor 1, axonemal. (708 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a. (191 aa)
STRA6Stimulated by retinoic acid 6. (707 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform 1. (707 aa)
ENSMMUP00000044881A_deaminase domain-containing protein. (74 aa)
CCN2Cellular communication network factor 2. (349 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1466 aa)
RCN3Uncharacterized protein. (326 aa)
PDPNPodoplanin. (162 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
LTA4HLeukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (611 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (566 aa)
LIFLIF interleukin 6 family cytokine. (206 aa)
CCDC39Coiled-coil domain containing 39. (942 aa)
TBX2T-box transcription factor 2. (712 aa)
RBBP9Putative hydrolase RBBP9. (186 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ASXL1ASXL transcriptional regulator 1. (1541 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
EPAS1Endothelial PAS domain protein 1. (875 aa)
KLF2Kruppel like factor 2. (355 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1111 aa)
ENSMMUP00000056315Uncharacterized protein. (152 aa)
SOX11Transcription factor SOX. (441 aa)
AIMP2Aminoacyl tRNA synthetase complex interacting multifunctional protein 2. (533 aa)
GLI2GLI family zinc finger 2. (1569 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (436 aa)
RC3H2RING finger and CCCH-type zinc finger domain-containing protein 2 isoform 1. (1191 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
PPP3R1Uncharacterized protein. (171 aa)
HPS1HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (700 aa)
ENSMMUP00000061664Uncharacterized protein. (123 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CTNNB1Catenin beta-1. (781 aa)
HMGB1High mobility group box 1. (215 aa)
SPRY1Uncharacterized protein. (343 aa)
ENSMMUP00000063643Uncharacterized protein. (156 aa)
FOXF1Forkhead box F1. (432 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ENSMMUP00000065874Uncharacterized protein. (153 aa)
MAN1A2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (645 aa)
NKX2-1NK2 homeobox 1. (448 aa)
GLI3GLI family zinc finger 3. (1580 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
PROX1Prospero homeobox protein 1. (737 aa)
STK40Serine/threonine-protein kinase 40. (435 aa)
BAG6BCL2 associated athanogene 6. (1238 aa)
SMPD5Uncharacterized protein. (381 aa)
HOXA5Homeobox A5. (381 aa)
RSPO2Uncharacterized protein. (243 aa)
FOXA1Fork-head domain-containing protein. (470 aa)
FOXJ1Forkhead box J1. (421 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1177 aa)
LOXLysyl oxidase. (417 aa)
ATXN1LAXH domain-containing protein. (691 aa)
GATA6Transcription factor GATA-6. (595 aa)
SIM2SIM bHLH transcription factor 2. (667 aa)
FBXW9F-box and WD repeat domain containing 9. (502 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (383 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
THRBThyroid hormone receptor beta. (524 aa)
ARG1Arginase. (322 aa)
ENSMMUP00000075283Uncharacterized protein. (69 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
TCF21Transcription factor 21. (179 aa)
EP300Histone acetyltransferase p300. (2414 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1948 aa)
TBX4Uncharacterized protein. (544 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (780 aa)
HSPB11Uncharacterized protein. (233 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ENSMMUP00000079873ABC transporter domain-containing protein. (155 aa)
RIDAUncharacterized protein. (230 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
HSD11B1Uncharacterized protein. (292 aa)
NKX2-8NK2 homeobox 8. (235 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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