STRINGSTRING
IFT52 IFT52 IHH IHH HOXC11 HOXC11 HOXC10 HOXC10 CRABP2 CRABP2 FRAS1 FRAS1 FREM2 FREM2 IFT140 IFT140 SALL4 SALL4 BAX BAX BMP7 BMP7 TEAD4 TEAD4 NOG NOG ZBTB16 ZBTB16 ACD ACD FGF9 FGF9 HDAC1 HDAC1 SKI SKI MAP3K20 MAP3K20 FBN2 FBN2 DKK1 DKK1 ECE1 ECE1 PBX1 PBX1 CHD7 CHD7 FLVCR1 FLVCR1 LMBR1 LMBR1 TBX5 TBX5 MKS1 MKS1 RARG RARG CACNA1C CACNA1C HOXA10 HOXA10 HOXA13 HOXA13 PBX2 PBX2 INTU INTU FGF8 FGF8 SFRP2 SFRP2 MBNL1 MBNL1 NOTCH1 NOTCH1 CHST11 CHST11 SALL1 SALL1 DYNC2H1 DYNC2H1 SMAD4 SMAD4 BCL2L11 BCL2L11 WNT7A WNT7A ALDH1A2 ALDH1A2 MYH1 MYH1 RPGRIP1L RPGRIP1L WNT3 WNT3 GRHL2 GRHL2 NIPBL NIPBL OSR2 OSR2 FZD6 FZD6 PSEN1 PSEN1 HAND2 HAND2 SP8 SP8 WDR19 WDR19 LOC704750 LOC704750 LRP4 LRP4 LRP5 LRP5 HOXD12 HOXD12 TP63 TP63 MEGF8 MEGF8 HOXD10 HOXD10 LEF1 LEF1 WDPCP WDPCP HOXD9 HOXD9 CPLANE1 CPLANE1 NOTCH2 NOTCH2 RARB RARB DLX6 DLX6 SP9 SP9 RDH10 RDH10 PTCH1 PTCH1 GNA12 GNA12 TMEM107 TMEM107 TBX2 TBX2 TFAP2A TFAP2A HNF1A HNF1A HOXD11 HOXD11 HDAC2 HDAC2 OSR1 OSR1 PRRX1 PRRX1 MED1 MED1 CTNNB1 CTNNB1 HOXA11 HOXA11 SHOX2 SHOX2 ALX4 ALX4 TGFB2 TGFB2 SHH SHH CREBBP CREBBP GDF5 GDF5 AFF3 AFF3 GLI3 GLI3 RECK RECK RUNX2 RUNX2 EN1 EN1 RSPO2 RSPO2 ZNF358 ZNF358 IMPAD1 IMPAD1 C2CD3 C2CD3 PITX1 PITX1 TBC1D32 TBC1D32 ALX3 ALX3 WNT5A WNT5A DLX5 DLX5 HOXD13 HOXD13 FBXW4 FBXW4 BMP4 BMP4 MSX1 MSX1 TBX4 TBX4 FGF4 FGF4 TBX3 TBX3 BMPR1A BMPR1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFT52Intraflagellar transport protein 52 homolog. (437 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
HOXC11Homeobox C11. (304 aa)
HOXC10Homeobox protein Hox-C10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (342 aa)
CRABP2Cellular retinoic acid-binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4011 aa)
FREM2FRAS1 related extracellular matrix 2. (3170 aa)
IFT140Intraflagellar transport 140. (1462 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
BAXUncharacterized protein. (279 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TEAD4TUB like protein 3; Belongs to the TUB family. (728 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ZBTB16Uncharacterized protein. (673 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (455 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
SKISKI proto-oncogene. (730 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase MLT isoform 1. (800 aa)
FBN2Fibrillin 2. (2912 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
ECE1Endothelin converting enzyme 1. (780 aa)
PBX1Pre-B-cell leukemia transcription factor 1 isoform 1. (430 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7. (2998 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (555 aa)
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (490 aa)
TBX5T-box transcription factor 5. (518 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
RARGRetinoic acid receptor gamma. (454 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
HOXA10Homeobox A10. (410 aa)
HOXA13Homeobox A13. (226 aa)
PBX2Pre-B-cell leukemia transcription factor 2. (430 aa)
INTUInturned planar cell polarity protein. (942 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
MBNL1Muscleblind like splicing regulator 1. (399 aa)
NOTCH1Notch receptor 1. (2556 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
SALL1Spalt like transcription factor 1. (1324 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4314 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BCL2L11Uncharacterized protein. (292 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ALDH1A2Retinal dehydrogenase 2 isoform 1; Belongs to the aldehyde dehydrogenase family. (518 aa)
MYH1Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
RPGRIP1LC2 domain-containing protein. (1273 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
NIPBLNipped-B protein. (2804 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
HAND2BHLH domain-containing protein. (186 aa)
SP8Sp8 transcription factor. (508 aa)
WDR19WD_REPEATS_REGION domain-containing protein. (1348 aa)
LOC704750Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (512 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1905 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
HOXD12Homeobox domain-containing protein. (270 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
HOXD10Homeobox D10. (340 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
WDPCPWD repeat containing planar cell polarity effector. (708 aa)
HOXD9Homeobox D9. (345 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3266 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
RARBRetinoic acid receptor beta. (448 aa)
DLX6Distal-less homeobox 6. (292 aa)
SP9Sp9 transcription factor. (485 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
PTCH1Patched 1. (1452 aa)
GNA12G protein subunit alpha 12. (463 aa)
TMEM107Transmembrane protein 107. (207 aa)
TBX2T-box transcription factor 2. (712 aa)
TFAP2ATranscription factor AP-2 alpha. (445 aa)
HNF1AHNF1 homeobox A. (657 aa)
HOXD11Homeobox D11. (338 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
PRRX1Uncharacterized protein. (245 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
CTNNB1Catenin beta-1. (781 aa)
HOXA11Homeobox A11. (311 aa)
SHOX2Short stature homeobox 2. (355 aa)
ALX4ALX homeobox 4. (409 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
CREBBPCREB-binding protein isoform a. (2442 aa)
GDF5Growth differentiation factor 5. (499 aa)
AFF3AF4/FMR2 family member 3 isoform 1. (1225 aa)
GLI3GLI family zinc finger 3. (1580 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (962 aa)
RUNX2RUNX family transcription factor 2. (647 aa)
EN1Homeobox protein engrailed-like. (398 aa)
RSPO2Uncharacterized protein. (243 aa)
ZNF358Zinc finger protein 358. (575 aa)
IMPAD1Inositol monophosphatase domain containing 1. (384 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2353 aa)
PITX1Homeobox protein. (348 aa)
TBC1D32TBC1 domain family member 32. (1334 aa)
ALX3ALX homeobox 3. (343 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
DLX5Distal-less homeobox 5. (289 aa)
HOXD13Homeobox D13. (343 aa)
FBXW4F-box and WD repeat domain containing 4. (591 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
TBX4Uncharacterized protein. (544 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
TBX3T-box transcription factor 3. (743 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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