node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AR | CTNNB1 | ENSMMUP00000015004 | ENSMMUP00000062910 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Catenin beta-1. | 0.876 |
AR | FGF10 | ENSMMUP00000015004 | ENSMMUP00000053581 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.479 |
AR | LHCGR | ENSMMUP00000015004 | ENSMMUP00000013586 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.414 |
AR | SRD5A2 | ENSMMUP00000015004 | ENSMMUP00000065479 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.667 |
CTNNB1 | AR | ENSMMUP00000062910 | ENSMMUP00000015004 | Catenin beta-1. | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | 0.876 |
CTNNB1 | FGF8 | ENSMMUP00000062910 | ENSMMUP00000020713 | Catenin beta-1. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.458 |
CTNNB1 | LGR4 | ENSMMUP00000062910 | ENSMMUP00000037055 | Catenin beta-1. | Leucine-rich repeat-containing G-protein coupled receptor 4. | 0.426 |
CTNNB1 | SHH | ENSMMUP00000062910 | ENSMMUP00000065431 | Catenin beta-1. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.539 |
CTNNB1 | WNT9B | ENSMMUP00000062910 | ENSMMUP00000070542 | Catenin beta-1. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.424 |
FGF10 | AR | ENSMMUP00000053581 | ENSMMUP00000015004 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | 0.479 |
FGF10 | FGF8 | ENSMMUP00000053581 | ENSMMUP00000020713 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.573 |
FGF10 | SHH | ENSMMUP00000053581 | ENSMMUP00000065431 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.763 |
FGF10 | TBX3 | ENSMMUP00000053581 | ENSMMUP00000079291 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | T-box transcription factor 3. | 0.408 |
FGF8 | CTNNB1 | ENSMMUP00000020713 | ENSMMUP00000062910 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Catenin beta-1. | 0.458 |
FGF8 | FGF10 | ENSMMUP00000020713 | ENSMMUP00000053581 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.573 |
FGF8 | HOXD13 | ENSMMUP00000020713 | ENSMMUP00000075391 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Homeobox D13. | 0.500 |
FGF8 | SHH | ENSMMUP00000020713 | ENSMMUP00000065431 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.878 |
HOXD13 | FGF8 | ENSMMUP00000075391 | ENSMMUP00000020713 | Homeobox D13. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.500 |
HOXD13 | SHH | ENSMMUP00000075391 | ENSMMUP00000065431 | Homeobox D13. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.531 |
HSD17B3 | LHCGR | ENSMMUP00000038724 | ENSMMUP00000013586 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.663 |