(24 nodes) Thyroid gland development network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HOXA3	Homeobox A3. (443 aa)
	HOXD3	Homeobox D3. (432 aa)
	THRA	Thyroid hormone receptor alpha. (486 aa)
	DUOX2	Dual oxidase 2. (1546 aa)
	PAX8	Paired box 8. (456 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	SIX1	SIX homeobox 1. (284 aa)
	SRF	Serum response factor. (508 aa)
	EDNRA	Uncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	FOXE1	Forkhead box E1. (372 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (763 aa)
	TG	Thyroglobulin. (2643 aa)
	ENSMMUP00000049472	Uncharacterized protein. (370 aa)
	TBX1	T-box transcription factor 1. (496 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	HESX1	HESX homeobox 1. (185 aa)
	EDN1	Preproendothelin-1. (211 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	NKX2-1	NK2 homeobox 1. (448 aa)
	HOXA5	Homeobox A5. (381 aa)
	NKX2-5	NK2 homeobox 5. (324 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRAF	MAPK1	ENSMMUP00000044832	ENSMMUP00000016444	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.679
BRAF	MAPK3	ENSMMUP00000044832	ENSMMUP00000053373	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.706
BRAF	PAX8	ENSMMUP00000044832	ENSMMUP00000015207	B-Raf proto-oncogene, serine/threonine kinase.	Paired box 8.	0.436
DUOX2	FOXE1	ENSMMUP00000011460	ENSMMUP00000039526	Dual oxidase 2.	Forkhead box E1.	0.418
EDN1	EDNRA	ENSMMUP00000062615	ENSMMUP00000034731	Preproendothelin-1.	Uncharacterized protein; Belongs to the G-protein coupled receptor 1 family.	0.998
EDN1	FGF8	ENSMMUP00000062615	ENSMMUP00000020713	Preproendothelin-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.582
EDNRA	EDN1	ENSMMUP00000034731	ENSMMUP00000062615	Uncharacterized protein; Belongs to the G-protein coupled receptor 1 family.	Preproendothelin-1.	0.998
EDNRA	MAPK1	ENSMMUP00000034731	ENSMMUP00000016444	Uncharacterized protein; Belongs to the G-protein coupled receptor 1 family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.513
FGF10	FGF8	ENSMMUP00000053581	ENSMMUP00000020713	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.573
FGF10	MAPK3	ENSMMUP00000053581	ENSMMUP00000053373	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.446
FGF10	SHH	ENSMMUP00000053581	ENSMMUP00000065431	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.763
FGF8	EDN1	ENSMMUP00000020713	ENSMMUP00000062615	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Preproendothelin-1.	0.582
FGF8	FGF10	ENSMMUP00000020713	ENSMMUP00000053581	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.573
FGF8	MAPK3	ENSMMUP00000020713	ENSMMUP00000053373	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.434
FGF8	SHH	ENSMMUP00000020713	ENSMMUP00000065431	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.878
FOXE1	DUOX2	ENSMMUP00000039526	ENSMMUP00000011460	Forkhead box E1.	Dual oxidase 2.	0.418
FOXE1	NKX2-1	ENSMMUP00000039526	ENSMMUP00000066724	Forkhead box E1.	NK2 homeobox 1.	0.739
FOXE1	PAX8	ENSMMUP00000039526	ENSMMUP00000015207	Forkhead box E1.	Paired box 8.	0.787
FOXE1	TG	ENSMMUP00000039526	ENSMMUP00000046539	Forkhead box E1.	Thyroglobulin.	0.738
HOXA3	HOXA5	ENSMMUP00000072778	ENSMMUP00000070749	Homeobox A3.	Homeobox A5.	0.761