(26 nodes) Developmental induction network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HOXC11	Homeobox C11. (304 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1212 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (550 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	SALL1	Spalt like transcription factor 1. (1324 aa)
	GDNF	Glial cell derived neurotrophic factor. (342 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	HIPK1	Uncharacterized protein. (1598 aa)
	C12orf43	Chromosome 12 open reading frame 43. (298 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	HOXD11	Homeobox D11. (338 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	SPRY1	Uncharacterized protein. (343 aa)
	HOXA11	Homeobox A11. (311 aa)
	BMP2	Bone morphogenetic protein 2. (396 aa)
	NKX2-1	NK2 homeobox 1. (448 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	SOX8	SRY-box transcription factor 8. (617 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	SIX1	SIX homeobox 1. (284 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	FZD5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP4	ENSMMUP00000065891	ENSMMUP00000077296	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.940
BMP2	FGF1	ENSMMUP00000065891	ENSMMUP00000071478	Bone morphogenetic protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.525
BMP2	FGF10	ENSMMUP00000065891	ENSMMUP00000053581	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.536
BMP2	FGF8	ENSMMUP00000065891	ENSMMUP00000020713	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.592
BMP2	SOX9	ENSMMUP00000065891	ENSMMUP00000073101	Bone morphogenetic protein 2.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.493
BMP2	WNT2	ENSMMUP00000065891	ENSMMUP00000062667	Bone morphogenetic protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.424
BMP2	WNT4	ENSMMUP00000065891	ENSMMUP00000068014	Bone morphogenetic protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.410
BMP4	BMP2	ENSMMUP00000077296	ENSMMUP00000065891	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.940
BMP4	CTNNB1	ENSMMUP00000077296	ENSMMUP00000062910	Bone morphogenetic protein 4.	Catenin beta-1.	0.402
BMP4	FGF1	ENSMMUP00000077296	ENSMMUP00000071478	Bone morphogenetic protein 4.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.578
BMP4	FGF10	ENSMMUP00000077296	ENSMMUP00000053581	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.709
BMP4	FGF8	ENSMMUP00000077296	ENSMMUP00000020713	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.698
BMP4	GDNF	ENSMMUP00000077296	ENSMMUP00000024951	Bone morphogenetic protein 4.	Glial cell derived neurotrophic factor.	0.455
BMP4	SOX9	ENSMMUP00000077296	ENSMMUP00000073101	Bone morphogenetic protein 4.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.503
BMP4	WNT1	ENSMMUP00000077296	ENSMMUP00000020627	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.407
BMP4	WNT2	ENSMMUP00000077296	ENSMMUP00000062667	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.474
BMP4	WNT3	ENSMMUP00000077296	ENSMMUP00000027394	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.567
CTNNB1	BMP4	ENSMMUP00000062910	ENSMMUP00000077296	Catenin beta-1.	Bone morphogenetic protein 4.	0.402
CTNNB1	FGF8	ENSMMUP00000062910	ENSMMUP00000020713	Catenin beta-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.458
CTNNB1	FZD5	ENSMMUP00000062910	ENSMMUP00000079324	Catenin beta-1.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.498