(41 nodes) Negative regulation of TOR signaling network (Macaca mulatta)

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	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	TBC1D7	TBC1 domain family member 7. (293 aa)
	UBR1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1749 aa)
	ITFG2	Integrin alpha FG-GAP repeat containing 2. (472 aa)
	SESN3	Sestrin-3. (492 aa)
	NPRL3	Nitrogen permease regulator 3-like protein isoform 1. (569 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	TNFAIP8L1	TNF alpha induced protein 8 like 1. (417 aa)
	CRYBA1	Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (215 aa)
	KPTN	Kaptin, actin binding protein. (525 aa)
	RNF167	RING-type domain-containing protein. (374 aa)
	ENSMMUP00000078057	Uncharacterized protein. (116 aa)
	AKT1S1	Uncharacterized protein. (277 aa)
	SESN1	Sestrin 1. (567 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (680 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
	MAPKAPK5	MAP kinase-activated protein kinase 5 isoform 1. (471 aa)
	C11H12orf66	Chromosome 11 C12orf66 homolog. (566 aa)
	STK11	Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa)
	SH3BP4	SH3 domain-binding protein 4. (963 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a. (626 aa)
	SPAAR	Small regulatory polypeptide of amino acid response. (90 aa)
	EPM2A	EPM2A glucan phosphatase, laforin. (331 aa)
	MINAR1	UPF0258 domain-containing protein. (936 aa)
	DDIT4	Uncharacterized protein. (261 aa)
	NPRL2	NPR2 like, GATOR1 complex subunit. (411 aa)
	RNF152	RING finger protein 152. (203 aa)
	WDR24	WD repeat domain 24. (790 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform 1. (826 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (409 aa)
	BMT2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
	CASTOR2	GATS-like protein 2. (329 aa)
	SIRT1	Sirtuin 1. (743 aa)
	TTC33	Non-specific serine/threonine protein kinase. (581 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (3432 aa)
	TSC1	TSC complex subunit 1. (1164 aa)
	WDR59	WD repeat domain 59. (1001 aa)
	TMEM127	Transmembrane protein 127. (238 aa)
	SESN2	Sestrin-2. (480 aa)
	SEC13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
	TSC2	TSC complex subunit 2. (2057 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	DEPTOR	ENSMMUP00000077587	ENSMMUP00000055765	Uncharacterized protein.	DEP domain containing MTOR interacting protein.	0.924
AKT1S1	PRKAA2	ENSMMUP00000077587	ENSMMUP00000013649	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.687
AKT1S1	SESN2	ENSMMUP00000077587	ENSMMUP00000026289	Uncharacterized protein.	Sestrin-2.	0.412
AKT1S1	SESN3	ENSMMUP00000077587	ENSMMUP00000012297	Uncharacterized protein.	Sestrin-3.	0.412
AKT1S1	TSC1	ENSMMUP00000077587	ENSMMUP00000012977	Uncharacterized protein.	TSC complex subunit 1.	0.634
AKT1S1	TSC2	ENSMMUP00000077587	ENSMMUP00000003781	Uncharacterized protein.	TSC complex subunit 2.	0.618
AKT1S1	TTC33	ENSMMUP00000077587	ENSMMUP00000031354	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.687
ARNTL	HIF1A	ENSMMUP00000069046	ENSMMUP00000056541	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a.	Hypoxia-inducible factor 1-alpha isoform 1.	0.746
ARNTL	SIRT1	ENSMMUP00000069046	ENSMMUP00000035809	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a.	Sirtuin 1.	0.819
ATM	DEPTOR	ENSMMUP00000005561	ENSMMUP00000055765	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DEP domain containing MTOR interacting protein.	0.401
ATM	SIRT1	ENSMMUP00000005561	ENSMMUP00000035809	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Sirtuin 1.	0.671
ATM	STK11	ENSMMUP00000005561	ENSMMUP00000029217	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily.	0.630
ATM	TSC2	ENSMMUP00000005561	ENSMMUP00000003781	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TSC complex subunit 2.	0.500
ATM	TTC33	ENSMMUP00000005561	ENSMMUP00000031354	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Non-specific serine/threonine protein kinase.	0.643
BMT2	C11H12orf66	ENSMMUP00000045316	ENSMMUP00000071588	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Chromosome 11 C12orf66 homolog.	0.908
BMT2	CASTOR2	ENSMMUP00000045316	ENSMMUP00000043718	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	GATS-like protein 2.	0.458
BMT2	DEPTOR	ENSMMUP00000045316	ENSMMUP00000055765	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	DEP domain containing MTOR interacting protein.	0.435
BMT2	ITFG2	ENSMMUP00000045316	ENSMMUP00000009736	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Integrin alpha FG-GAP repeat containing 2.	0.910
BMT2	KPTN	ENSMMUP00000045316	ENSMMUP00000019318	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Kaptin, actin binding protein.	0.853
BMT2	NPRL2	ENSMMUP00000045316	ENSMMUP00000064708	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	NPR2 like, GATOR1 complex subunit.	0.854