(23 nodes) Positive regulation of cell adhesion mediated by integrin network (Macaca mulatta)

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Your Input:
	PODXL	Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (522 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (741 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (626 aa)
	LRRC45	Leucine rich repeat containing 45. (670 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1115 aa)
	SFRP2	Secreted frizzled-related protein 2. (295 aa)
	ADAM9	ADAM metallopeptidase domain 9. (848 aa)
	NCKAP1L	NCK associated protein 1 like. (1134 aa)
	IFT74	Intraflagellar transport protein 74 homolog isoform a. (600 aa)
	FERMT1	Fermitin family member 1. (677 aa)
	CIB1	Calcium and integrin-binding protein 1. (191 aa)
	CXCL13	C-X-C motif chemokine. (109 aa)
	LIF	LIF interleukin 6 family cytokine. (206 aa)
	LOC709999	Uncharacterized protein. (831 aa)
	CD3E	CD3e molecule. (217 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	ADAM1	Uncharacterized protein. (911 aa)
	ENSMMUP00000065554	Uncharacterized protein. (459 aa)
	PIEZO1	Piezo-type mechanosensitive ion channel component. (2525 aa)
	CCL21	C-C motif chemokine 21; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity). (131 aa)
	FOXC2	Forkhead box C2. (471 aa)
	SKAP1	Src kinase associated phosphoprotein 1. (457 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL21	CXCL13	ENSMMUP00000070168	ENSMMUP00000048114	C-C motif chemokine 21; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).	C-X-C motif chemokine.	0.868
CD3E	PTPN6	ENSMMUP00000062612	ENSMMUP00000013344	CD3e molecule.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.711
CD3E	SKAP1	ENSMMUP00000062612	ENSMMUP00000076711	CD3e molecule.	Src kinase associated phosphoprotein 1.	0.436
CD3E	SYK	ENSMMUP00000062612	ENSMMUP00000063860	CD3e molecule.	Tyrosine-protein kinase.	0.959
CXCL13	CCL21	ENSMMUP00000048114	ENSMMUP00000070168	C-X-C motif chemokine.	C-C motif chemokine 21; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).	0.868
FERMT1	ITGB3	ENSMMUP00000037513	ENSMMUP00000004380	Fermitin family member 1.	Integrin beta; Belongs to the integrin beta chain family.	0.454
ITGB3	FERMT1	ENSMMUP00000004380	ENSMMUP00000037513	Integrin beta; Belongs to the integrin beta chain family.	Fermitin family member 1.	0.454
ITGB3	SYK	ENSMMUP00000004380	ENSMMUP00000063860	Integrin beta; Belongs to the integrin beta chain family.	Tyrosine-protein kinase.	0.628
ITGB3	TGFB2	ENSMMUP00000004380	ENSMMUP00000064264	Integrin beta; Belongs to the integrin beta chain family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.574
PTPN6	CD3E	ENSMMUP00000013344	ENSMMUP00000062612	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	CD3e molecule.	0.711
PTPN6	RET	ENSMMUP00000013344	ENSMMUP00000020196	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.571
PTPN6	SKAP1	ENSMMUP00000013344	ENSMMUP00000076711	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Src kinase associated phosphoprotein 1.	0.509
PTPN6	SYK	ENSMMUP00000013344	ENSMMUP00000063860	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein kinase.	0.985
RET	PTPN6	ENSMMUP00000020196	ENSMMUP00000013344	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.571
SKAP1	CD3E	ENSMMUP00000076711	ENSMMUP00000062612	Src kinase associated phosphoprotein 1.	CD3e molecule.	0.436
SKAP1	PTPN6	ENSMMUP00000076711	ENSMMUP00000013344	Src kinase associated phosphoprotein 1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.509
SKAP1	SYK	ENSMMUP00000076711	ENSMMUP00000063860	Src kinase associated phosphoprotein 1.	Tyrosine-protein kinase.	0.573
SYK	CD3E	ENSMMUP00000063860	ENSMMUP00000062612	Tyrosine-protein kinase.	CD3e molecule.	0.959
SYK	ITGB3	ENSMMUP00000063860	ENSMMUP00000004380	Tyrosine-protein kinase.	Integrin beta; Belongs to the integrin beta chain family.	0.628
SYK	PTPN6	ENSMMUP00000063860	ENSMMUP00000013344	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.985