STRINGSTRING
SIRT6 SIRT6 CDK13 CDK13 ERCC6 ERCC6 LRRC27 LRRC27 VHLL VHLL HEXIM1 HEXIM1 CDK12 CDK12 SHH SHH LOC114675526 LOC114675526 INTS5 INTS5 INTS2 INTS2 BTBD18 BTBD18 INTS13 INTS13 INTS8 INTS8 ELL2 ELL2 NELFB NELFB SUPT6H SUPT6H RNF168 RNF168 MED21 MED21 MED19 MED19 MED27 MED27 ELL3 ELL3 EAF2 EAF2 AXIN1 AXIN1 SUPT16H SUPT16H LOC100426235 LOC100426235 MED26 MED26 CTNNB1 CTNNB1 VHL VHL INTS7 INTS7 MED9 MED9 INTS6 INTS6 MED29 MED29 EZH2 EZH2 CCNK CCNK ZMYND11 ZMYND11 MED11 MED11 NELFCD NELFCD MED30 MED30 NELFA NELFA ELL ELL NCBP1 NCBP1 MED25 MED25 MED23 MED23 SUPT4H1 SUPT4H1 NELFE NELFE WDR43 WDR43 CCNT1 CCNT1 MED7 MED7 MED18 MED18 INTS4 INTS4 MED16 MED16 LDB1 LDB1 INTS14 INTS14 LOC702124 LOC702124 CDC73 CDC73 HNRNPU HNRNPU MED15 MED15 CCNT2 CCNT2 MED24 MED24 BRD4 BRD4 INTS1 INTS1 RECQL5 RECQL5 EAPP EAPP MED4 MED4 CDK9 CDK9 MED31 MED31 MED8 MED8 TCERG1 TCERG1 MED14 MED14 CBX7 CBX7 F6TR90_MACMU F6TR90_MACMU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIRT6NAD-dependent deacetylase sirtuin-6. (355 aa)
CDK13Cyclin dependent kinase 13. (1511 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (2061 aa)
LRRC27Leucine rich repeat containing 27. (707 aa)
VHLLVHL like. (181 aa)
HEXIM1Protein HEXIM1. (359 aa)
CDK12Cyclin-dependent kinase 12 isoform 2. (1481 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
LOC114675526BTB/POZ domain-containing protein 18. (713 aa)
INTS5Integrator complex subunit 5. (1019 aa)
INTS2Integrator complex subunit 2. (1196 aa)
BTBD18BTB/POZ domain-containing protein 18. (713 aa)
INTS13Cell cycle regulator Mat89Bb homolog. (706 aa)
INTS8Integrator complex subunit 8. (995 aa)
ELL2Elongation factor for RNA polymerase II 2. (641 aa)
NELFBNegative elongation factor complex member B. (580 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (661 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (208 aa)
MED19Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (244 aa)
MED27Mediator of RNA polymerase II transcription subunit 27. (311 aa)
ELL3Elongation factor for RNA polymerase II 3. (399 aa)
EAF2EAF domain-containing protein. (261 aa)
AXIN1Axin 1. (867 aa)
SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa)
LOC100426235Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (252 aa)
MED26TFIIS N-terminal domain-containing protein. (615 aa)
CTNNB1Catenin beta-1. (781 aa)
VHLVon Hippel-Lindau disease tumor suppressor isoform 1. (213 aa)
INTS7Integrator complex subunit 7. (962 aa)
MED9Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (156 aa)
INTS6Integrator complex subunit 6 isoform a. (887 aa)
MED29Mediator complex subunit 29. (200 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (832 aa)
CCNKCyclin K; Belongs to the cyclin family. (580 aa)
ZMYND11Zinc finger MYND domain-containing protein 11 isoform a. (602 aa)
MED11Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (206 aa)
NELFCDNegative elongation factor complex member C/D. (599 aa)
MED30Mediator of RNA polymerase II transcription subunit 30. (178 aa)
NELFANegative elongation factor complex member A. (539 aa)
ELLElongation factor for RNA polymerase II. (621 aa)
NCBP1Nuclear cap-binding protein subunit 1. (790 aa)
MED25Mediator complex subunit 25. (796 aa)
MED23Mediator complex subunit 23. (1374 aa)
SUPT4H1Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (117 aa)
NELFENegative elongation factor complex member E. (338 aa)
WDR43WD repeat domain 43. (678 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (728 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (232 aa)
MED18Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (208 aa)
INTS4Integrator complex subunit 4. (964 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (877 aa)
LDB1LIM domain-binding protein 1 isoform 1. (411 aa)
INTS14Integrator complex subunit 14. (518 aa)
LOC702124Uncharacterized protein. (950 aa)
CDC73Parafibromin. (531 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (788 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (709 aa)
MED24Mediator of RNA polymerase II transcription subunit 24 isoform 1. (989 aa)
BRD4Bromodomain containing 4. (1334 aa)
INTS1Integrator complex subunit 1. (2190 aa)
RECQL5RecQ like helicase 5. (1027 aa)
EAPPE2F-associated phosphoprotein. (285 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (362 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
MED31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
MED8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (378 aa)
TCERG1Transcription elongation regulator 1. (1115 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1454 aa)
CBX7Chromo domain-containing protein. (251 aa)
F6TR90_MACMUOccludin_ELL domain-containing protein. (337 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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