STRINGSTRING
POLA2 POLA2 UTP25 UTP25 STK11 STK11 NXT1 NXT1 NFKBIA NFKBIA SKP1-2 SKP1-2 PLRG1 PLRG1 NUP35 NUP35 HDGF HDGF RAP1GDS1 RAP1GDS1 ENSMMUP00000056458 ENSMMUP00000056458 LMNB1 LMNB1 NUP98 NUP98 PARK7 PARK7 NUP85 NUP85 KPNA4 KPNA4 APPL1 APPL1 PPP3CA PPP3CA PPP3R1 PPP3R1 AKT1 AKT1 NUP133 NUP133 MED1 MED1 ZBTB7A ZBTB7A FAM53B FAM53B SYK SYK CRY2 CRY2 SHH SHH ADAR ADAR NUP62CL NUP62CL NUP50 NUP50 SNUPN SNUPN LOC100428605 LOC100428605 DCLK3 DCLK3 TPR TPR GLI3 GLI3 NOL8 NOL8 NUAK2 NUAK2 APPL2 APPL2 PIKFYVE PIKFYVE ARL2BP ARL2BP RAN RAN CBLB CBLB LMNB2 LMNB2 TOR1AIP1 TOR1AIP1 ABRA ABRA NUTF2 NUTF2 PYGO1 PYGO1 NPAP1 NPAP1 ENSMMUP00000073605 ENSMMUP00000073605 SUN1 SUN1 IPO7 IPO7 DCLK1 DCLK1 ENSMMUP00000075922 ENSMMUP00000075922 BMP4 BMP4 MSX1 MSX1 RANGAP1 RANGAP1 CDKN1A CDKN1A BCL3 BCL3 NUP214 NUP214 PINX1 PINX1 TMEM201 TMEM201 LOC106992761 LOC106992761 WRN WRN SIX2 SIX2 NUP62 NUP62 TNPO2 TNPO2 CNEP1R1 CNEP1R1 RANBP17 RANBP17 FAM53C FAM53C IPO11 IPO11 TAF3 TAF3 XPO1 XPO1 TBRG1 TBRG1 EIF4ENIF1 EIF4ENIF1 HNRNPU HNRNPU TOR1AIP2 TOR1AIP2 LMNA LMNA NUP107 NUP107 NDUFB6 NDUFB6 LOC713290 LOC713290 PRICKLE1 PRICKLE1 IPO8 IPO8 STAT3 STAT3 SP100 SP100 TNPO3 TNPO3 RPF2 RPF2 RANBP2 RANBP2 SUMO1 SUMO1 STK3 STK3 IPO4 IPO4 E2F3 E2F3 DVL1 DVL1 OSBPL8 OSBPL8 CALR CALR KPNA6 KPNA6 ATF2 ATF2 YWHAE YWHAE NUP155 NUP155 RPAIN RPAIN TNPO1 TNPO1 PTTG1IP PTTG1IP KPNA5 KPNA5 RRS1 RRS1 COL1A1 COL1A1 SIX4 SIX4 IPO9 IPO9 SHISA4 SHISA4 NUP153 NUP153 TRAF3IP2 TRAF3IP2 DCLK2 DCLK2 POM121C POM121C PML PML AKIRIN2 AKIRIN2 TSC2 TSC2 TOR1B TOR1B TOR1A TOR1A BMP7 BMP7 MMP12 MMP12 GCKR GCKR CHCHD10 CHCHD10 BARD1 BARD1 INTS13 INTS13 GPN3 GPN3 ELAVL1 ELAVL1 NF1 NF1 ZBTB16 ZBTB16 SUN2 SUN2 FAM53A FAM53A WRAP53 WRAP53 TP53 TP53 BANP BANP CLDN18 CLDN18 RRP7A RRP7A FGF9 FGF9 NUP88 NUP88 CTDNEP1 CTDNEP1 PIK3R1 PIK3R1 HHEX HHEX SMO SMO XPA XPA ARL2 ARL2 TAF8 TAF8 NXT2 NXT2 STK4 STK4 NOP53 NOP53 IPO5 IPO5 RANGRF RANGRF BBS4 BBS4 CIZ1 CIZ1 NR5A1 NR5A1 MDM2 MDM2 SPG11 SPG11 ING1 ING1 ABCA7 ABCA7 LRRK2 LRRK2 KPNA1 KPNA1 F6VLV0_MACMU F6VLV0_MACMU KPNA2 KPNA2 NOTCH1 NOTCH1 PLK1 PLK1 HIKESHI HIKESHI TMCO6 TMCO6 GPN2 GPN2 SYNE1 SYNE1 F6T365_MACMU F6T365_MACMU KPNA7 KPNA7 SUPT7L SUPT7L KPNB1 KPNB1 SEC13 SEC13 MORC3 MORC3 HEATR3 HEATR3 CDK5 CDK5 KPNA3 KPNA3 NUP54 NUP54 MAGED1 MAGED1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
UTP25Digestive organ expansion factor homolog. (755 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa)
NXT1Nuclear transport factor 2 like export factor 1. (140 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
SKP1-2Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
PLRG1Pleiotropic regulator 1 isoform 1. (514 aa)
NUP35Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (326 aa)
HDGFHepatoma-derived growth factor isoform b. (256 aa)
RAP1GDS1Rap1 GTPase-GDP dissociation stimulator 1 isoform 3. (607 aa)
ENSMMUP00000056458Uncharacterized protein. (137 aa)
LMNB1Lamin-B1 isoform 1; Belongs to the intermediate filament family. (586 aa)
NUP98Nucleoporin 98. (1876 aa)
PARK7Protein DJ-1. (189 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (656 aa)
KPNA4Importin subunit alpha; Functions in nuclear protein import. (548 aa)
APPL1Uncharacterized protein. (846 aa)
PPP3CASerine/threonine-protein phosphatase. (547 aa)
PPP3R1Uncharacterized protein. (171 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NUP133Nucleoporin 133. (1157 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (692 aa)
FAM53BUncharacterized protein. (422 aa)
SYKTyrosine-protein kinase. (635 aa)
CRY2Cryptochrome circadian regulator 2. (593 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ADARAdenosine deaminase RNA specific. (1268 aa)
NUP62CLNucleoporin-62 C-terminal-like protein. (184 aa)
NUP50Nuclear pore complex protein Nup50 isoform b. (468 aa)
SNUPNSnurportin 1. (436 aa)
LOC100428605Uncharacterized protein. (479 aa)
DCLK3Doublecortin like kinase 3. (648 aa)
TPRTPR_MLP1_2 domain-containing protein. (2404 aa)
GLI3GLI family zinc finger 3. (1580 aa)
NOL8Nucleolar protein 8. (1166 aa)
NUAK2NUAK family kinase 2. (628 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (664 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2110 aa)
ARL2BPADP ribosylation factor like GTPase 2 binding protein. (203 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (280 aa)
CBLBCbl proto-oncogene B. (982 aa)
LMNB2Lamin B2; Belongs to the intermediate filament family. (628 aa)
TOR1AIP1Torsin 1A interacting protein 1. (750 aa)
ABRAActin binding Rho activating protein. (381 aa)
NUTF2Nuclear transport factor 2. (127 aa)
PYGO1Pygopus family PHD finger 1. (419 aa)
NPAP1Nuclear pore associated protein 1. (1158 aa)
ENSMMUP00000073605Ribosomal_L5_C domain-containing protein; Belongs to the universal ribosomal protein uL5 family. (147 aa)
SUN1Sad1 and UNC84 domain containing 1. (1065 aa)
IPO7Importin-7. (1038 aa)
DCLK1Doublecortin like kinase 1. (759 aa)
ENSMMUP00000075922Uncharacterized protein. (570 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
RANGAP1Ran GTPase activating protein 1. (709 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
BCL3BCL3 transcription coactivator. (454 aa)
NUP214Nucleoporin 214. (2259 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (452 aa)
TMEM201Transmembrane protein 201 isoform 1. (667 aa)
LOC106992761HSR domain-containing protein. (317 aa)
WRNWRN RecQ like helicase. (1426 aa)
SIX2SIX homeobox 2. (292 aa)
NUP62Nuclear pore glycoprotein p62. (521 aa)
TNPO2Transportin-2 isoform 1. (897 aa)
CNEP1R1CTD nuclear envelope phosphatase 1 regulatory subunit 1. (142 aa)
RANBP17RAN binding protein 17. (1088 aa)
FAM53CProtein FAM53C. (392 aa)
IPO11Importin 11. (991 aa)
TAF3TATA-box binding protein associated factor 3. (1008 aa)
XPO1Exportin-1. (1071 aa)
TBRG1Transforming growth factor beta regulator 1. (411 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (1121 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
TOR1AIP2Torsin-1A-interacting protein 2 isoform b. (470 aa)
LMNAPrelamin-A/C isoform 1; Belongs to the intermediate filament family. (663 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa)
NDUFB6RING-type domain-containing protein. (1085 aa)
LOC713290Uncharacterized protein. (702 aa)
PRICKLE1Prickle planar cell polarity protein 1. (848 aa)
IPO8Importin-8 isoform 1. (1037 aa)
STAT3Signal transducer and activator of transcription. (871 aa)
SP100SP100 nuclear antigen. (870 aa)
TNPO3Transportin-3 isoform 1. (923 aa)
RPF2Ribosome production factor 2 homolog. (306 aa)
RANBP2RAN binding protein 2. (3247 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
STK3Uncharacterized protein. (519 aa)
IPO4Importin 4. (1081 aa)
E2F3E2F transcription factor 3. (465 aa)
DVL1Dishevelled segment polarity protein 1. (695 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (902 aa)
CALRCalreticulin. (417 aa)
KPNA6Importin subunit alpha; Functions in nuclear protein import. (566 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
NUP155Nucleoporin 155. (1449 aa)
RPAINUncharacterized protein. (228 aa)
TNPO1Transportin-1 isoform 1. (898 aa)
PTTG1IPPituitary tumor-transforming gene 1 protein-interacting protein. (180 aa)
KPNA5Importin subunit alpha; Functions in nuclear protein import. (562 aa)
RRS1Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa)
COL1A1Collagen alpha-1(I) chain preproprotein. (1464 aa)
SIX4SIX homeobox 4. (772 aa)
IPO9Importin 9. (1042 aa)
SHISA4Shisa family member 4. (234 aa)
NUP153Uncharacterized protein. (1474 aa)
TRAF3IP2SEFIR domain-containing protein. (572 aa)
DCLK2Doublecortin like kinase 2. (783 aa)
POM121CUncharacterized protein. (1225 aa)
PMLPromyelocytic leukemia protein. (882 aa)
AKIRIN2Akirin 2. (427 aa)
TSC2TSC complex subunit 2. (2057 aa)
TOR1BTorsin family 1 member B. (371 aa)
TOR1ATorsin family 1 member A. (532 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
GCKRGlucokinase regulator. (625 aa)
CHCHD10Coiled-coil-helix-coiled-coil-helix domain containing 10. (142 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
INTS13Cell cycle regulator Mat89Bb homolog. (706 aa)
GPN3GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (385 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
NF1Neurofibromin 1. (2867 aa)
ZBTB16Uncharacterized protein. (673 aa)
SUN2Sad1 and UNC84 domain containing 2. (800 aa)
FAM53AFamily with sequence similarity 53 member A. (396 aa)
WRAP53Telomerase Cajal body protein 1. (548 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
BANPBTG3 associated nuclear protein. (530 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
RRP7AUncharacterized protein. (348 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NUP88Nuclear pore complex protein Nup88. (741 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (387 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
HHEXHematopoietically expressed homeobox. (270 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
XPAXPA, DNA damage recognition and repair factor. (294 aa)
ARL2ADP-ribosylation factor-like protein 2 isoform 1; Belongs to the small GTPase superfamily. Arf family. (184 aa)
TAF8TATA-box binding protein associated factor 8. (367 aa)
NXT2NTF2-related export protein 2 isoform 1. (197 aa)
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)
NOP53Uncharacterized protein. (496 aa)
IPO5Importin 5. (1097 aa)
RANGRFUncharacterized protein. (186 aa)
BBS4Bardet-Biedl syndrome 4 protein. (519 aa)
CIZ1CDKN1A interacting zinc finger protein 1. (906 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (500 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2487 aa)
ING1Inhibitor of growth protein. (279 aa)
ABCA7ATP binding cassette subfamily A member 7. (2111 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
F6VLV0_MACMUUncharacterized protein. (278 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
NOTCH1Notch receptor 1. (2556 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
TMCO6Transmembrane and coiled-coil domains 6. (493 aa)
GPN2GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (310 aa)
SYNE1Spectrin repeat containing nuclear envelope protein 1. (8797 aa)
F6T365_MACMU14_3_3 domain-containing protein. (74 aa)
KPNA7Importin subunit alpha; Functions in nuclear protein import. (515 aa)
SUPT7LSPT7 like, STAGA complex gamma subunit. (412 aa)
KPNB1Karyopherin subunit beta 1. (856 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
MORC3MORC family CW-type zinc finger 3. (940 aa)
HEATR3HEAT repeat-containing protein 3. (680 aa)
CDK5Cyclin dependent kinase 5. (364 aa)
KPNA3Importin subunit alpha; Functions in nuclear protein import. (521 aa)
NUP54Nucleoporin 54. (562 aa)
MAGED1MAGE family member D1. (834 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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