(32 nodes) Hindlimb morphogenesis network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	TBX4	Uncharacterized protein. (544 aa)
	MSX1	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	ALX3	ALX homeobox 3. (343 aa)
	PITX1	Homeobox protein. (348 aa)
	RSPO2	Uncharacterized protein. (243 aa)
	AFF3	AF4/FMR2 family member 3 isoform 1. (1225 aa)
	GDF5	Growth differentiation factor 5. (499 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	FMN1	Formin 1. (1425 aa)
	ZBTB16	Uncharacterized protein. (673 aa)
	CHD7	Chromodomain-helicase-DNA-binding protein 7. (2998 aa)
	RARG	Retinoic acid receptor gamma. (454 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	RPGRIP1L	C2 domain-containing protein. (1273 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	OSR2	Odd-skipped related transciption factor 2. (276 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	HOXD10	Homeobox D10. (340 aa)
	HOXD9	Homeobox D9. (345 aa)
	RARB	Retinoic acid receptor beta. (448 aa)
	PTCH1	Patched 1. (1452 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	ALX4	ALX homeobox 4. (409 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	TFAP2B	Transcription factor AP-2 beta. (504 aa)
	TBX3	T-box transcription factor 3. (743 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMPR1A	ENSMMUP00000077296	ENSMMUP00000079770	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.995
BMP4	CTNNB1	ENSMMUP00000077296	ENSMMUP00000062910	Bone morphogenetic protein 4.	Catenin beta-1.	0.402
BMP4	FGF4	ENSMMUP00000077296	ENSMMUP00000079036	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.691
BMP4	FGF8	ENSMMUP00000077296	ENSMMUP00000020713	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.698
BMP4	GDF5	ENSMMUP00000077296	ENSMMUP00000066144	Bone morphogenetic protein 4.	Growth differentiation factor 5.	0.500
BMP4	MSX1	ENSMMUP00000077296	ENSMMUP00000077484	Bone morphogenetic protein 4.	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity).	0.660
BMP4	NOTCH1	ENSMMUP00000077296	ENSMMUP00000022401	Bone morphogenetic protein 4.	Notch receptor 1.	0.509
BMP4	PTCH1	ENSMMUP00000077296	ENSMMUP00000051035	Bone morphogenetic protein 4.	Patched 1.	0.616
BMP4	SHH	ENSMMUP00000077296	ENSMMUP00000065431	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.747
BMP4	TBX3	ENSMMUP00000077296	ENSMMUP00000079291	Bone morphogenetic protein 4.	T-box transcription factor 3.	0.604
BMP4	WNT3	ENSMMUP00000077296	ENSMMUP00000027394	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.567
BMP4	WNT7A	ENSMMUP00000077296	ENSMMUP00000024267	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.586
BMPR1A	BMP4	ENSMMUP00000079770	ENSMMUP00000077296	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.995
BMPR1A	CTNNB1	ENSMMUP00000079770	ENSMMUP00000062910	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Catenin beta-1.	0.466
BMPR1A	GDF5	ENSMMUP00000079770	ENSMMUP00000066144	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Growth differentiation factor 5.	0.991
BMPR1A	OSR1	ENSMMUP00000079770	ENSMMUP00000058804	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Odd-skipped related transcription factor 1.	0.423
CHD7	CTNNB1	ENSMMUP00000015218	ENSMMUP00000062910	Chromodomain-helicase-DNA-binding protein 7.	Catenin beta-1.	0.696
CHD7	FGF8	ENSMMUP00000015218	ENSMMUP00000020713	Chromodomain-helicase-DNA-binding protein 7.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.455
CTNNB1	BMP4	ENSMMUP00000062910	ENSMMUP00000077296	Catenin beta-1.	Bone morphogenetic protein 4.	0.402
CTNNB1	BMPR1A	ENSMMUP00000062910	ENSMMUP00000079770	Catenin beta-1.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.466