STRINGSTRING
HEG1 HEG1 TGFBR3 TGFBR3 TMEM38B TMEM38B LEPR LEPR YAP1 YAP1 MMP13 MMP13 F7FM70_MACMU F7FM70_MACMU LEP LEP FOXC1 FOXC1 PRLR PRLR COMP COMP PTEN PTEN F6V457_MACMU F6V457_MACMU COL27A1 COL27A1 EXT1 EXT1 FGF7 FGF7 FGF9 FGF9 TGFBR2 TGFBR2 MESP1 MESP1 AKAP13 AKAP13 AR AR PDGFRB PDGFRB TBX5 TBX5 CER1 CER1 RARA RARA RARG RARG PSAP PSAP STK4 STK4 MAPK11 MAPK11 BMP10 BMP10 FGF8 FGF8 ARID2 ARID2 NOTCH1 NOTCH1 IFT80 IFT80 RAG2 RAG2 SMAD1 SMAD1 F6YF69_MACMU F6YF69_MACMU ACVR2B ACVR2B GATA4 GATA4 SMPD3 SMPD3 FGFR3 FGFR3 OSTN OSTN EVC EVC DLL1 DLL1 PDLIM5 PDLIM5 F6YRT5_MACMU F6YRT5_MACMU LOC114670311 LOC114670311 LOC723080 LOC723080 F6RVH3_MACMU F6RVH3_MACMU F6RVG4_MACMU F6RVG4_MACMU THBS3 THBS3 JARID2 JARID2 DDR2 DDR2 EHMT2 EHMT2 ZMPSTE24 ZMPSTE24 ANXA6 ANXA6 MAP2K4 MAP2K4 SMAD2 SMAD2 STK3 STK3 S1PR1 S1PR1 DIPK2A DIPK2A FGFR2 FGFR2 NDRG4 NDRG4 RARB RARB ATF2 ATF2 PTPN11 PTPN11 FXN FXN IL7 IL7 CYP19A1 CYP19A1 FGF10 FGF10 DCUN1D2 DCUN1D2 SAV1 SAV1 ADRA1A ADRA1A ENSMMUP00000054772 ENSMMUP00000054772 UBE3A UBE3A ECM1 ECM1 BNC2 BNC2 TSKU TSKU WNT2 WNT2 SORBS2 SORBS2 HEY2 HEY2 ENSMMUP00000063650 ENSMMUP00000063650 LOC713341 LOC713341 TGFB2 TGFB2 IER3IP1 IER3IP1 ENSMMUP00000064444 ENSMMUP00000064444 MATN1 MATN1 SHH SHH PSAPL1 PSAPL1 ANKRD26 ANKRD26 SPRY2 SPRY2 ESR1 ESR1 BCL2 BCL2 SMPD5 SMPD5 RSPO2 RSPO2 TENM4 TENM4 NKX2-5 NKX2-5 SOX9 SOX9 PLAG1 PLAG1 GATA6 GATA6 LOC706905 LOC706905 FOXC2 FOXC2 NPPC NPPC ARX ARX ANKRD30A ANKRD30A LOC114675655 LOC114675655 ENSMMUP00000077846 ENSMMUP00000077846 STC1 STC1 ENSMMUP00000078548 ENSMMUP00000078548 HLX HLX ENSMMUP00000080620 ENSMMUP00000080620
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HEG1Heart development protein with EGF like domains 1. (1486 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
TMEM38BTrimeric intracellular cation channel type B. (291 aa)
LEPRLeptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1163 aa)
YAP1Yes associated protein 1. (508 aa)
MMP13Matrix metallopeptidase 13. (471 aa)
F7FM70_MACMUANK_REP_REGION domain-containing protein. (167 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
FOXC1Forkhead box C1. (551 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (619 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
PTENUncharacterized protein. (589 aa)
F6V457_MACMUUncharacterized protein. (129 aa)
COL27A1Collagen type XXVII alpha 1 chain. (1853 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
AKAP13A-kinase anchoring protein 13. (2899 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (895 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
TBX5T-box transcription factor 5. (518 aa)
CER1Cerberus-related protein. (267 aa)
RARARetinoic acid receptor alpha isoform 1. (462 aa)
RARGRetinoic acid receptor gamma. (454 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (524 aa)
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
ARID2AT-rich interaction domain 2. (1836 aa)
NOTCH1Notch receptor 1. (2556 aa)
IFT80Intraflagellar transport protein 80 homolog isoform a. (777 aa)
RAG2Recombination activating 2. (532 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
F6YF69_MACMUUncharacterized protein. (673 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
GATA4GATA binding protein 4. (443 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
OSTNOsteocrin. (133 aa)
EVCEvC ciliary complex subunit 1. (992 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
PDLIM5PDZ and LIM domain 5. (686 aa)
F6YRT5_MACMUUncharacterized protein. (89 aa)
LOC114670311ANK_REP_REGION domain-containing protein. (545 aa)
LOC723080ANK_REP_REGION domain-containing protein. (526 aa)
F6RVH3_MACMUANK_REP_REGION domain-containing protein. (288 aa)
F6RVG4_MACMUANK_REP_REGION domain-containing protein. (475 aa)
THBS3Uncharacterized protein. (956 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1281 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (896 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1266 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
ANXA6Annexin. (673 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
STK3Uncharacterized protein. (519 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
DIPK2ADivergent protein kinase domain 2A. (458 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
NDRG4NDRG family member 4. (494 aa)
RARBRetinoic acid receptor beta. (448 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FXNFrataxin, mitochondrial isoform 1 preproprotein. (210 aa)
IL7Uncharacterized protein. (184 aa)
CYP19A1Cytochrome P450 19A1; Belongs to the cytochrome P450 family. (503 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DCUN1D2Defective in cullin neddylation 1 domain containing 2. (1866 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
ADRA1AAdrenoceptor alpha 1A. (445 aa)
ENSMMUP00000054772ANK_REP_REGION domain-containing protein. (330 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
ECM1Extracellular matrix protein 1 isoform 1. (540 aa)
BNC2Basonuclin 2. (1188 aa)
TSKUUncharacterized protein. (353 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
SORBS2Sorbin and SH3 domain containing 2. (1246 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
ENSMMUP00000063650Uncharacterized protein. (79 aa)
LOC713341ANK_REP_REGION domain-containing protein. (627 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IER3IP1Immediate early response 3-interacting protein 1. (82 aa)
ENSMMUP00000064444DUF3496 domain-containing protein. (72 aa)
MATN1Matrilin 1. (495 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PSAPL1Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. (521 aa)
ANKRD26Ankyrin repeat domain 26. (2064 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
SMPD5Uncharacterized protein. (381 aa)
RSPO2Uncharacterized protein. (243 aa)
TENM4Teneurin transmembrane protein 4. (2929 aa)
NKX2-5NK2 homeobox 5. (324 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
PLAG1Pleiomorphic adenoma gene 1 protein. (500 aa)
GATA6Transcription factor GATA-6. (595 aa)
LOC706905ANK_REP_REGION domain-containing protein. (618 aa)
FOXC2Forkhead box C2. (471 aa)
NPPCC-type natriuretic peptide. (126 aa)
ARXAristaless related homeobox. (562 aa)
ANKRD30AAnkyrin repeat domain 30A. (1174 aa)
LOC114675655ANK_REP_REGION domain-containing protein. (649 aa)
ENSMMUP00000077846DUF3496 domain-containing protein. (141 aa)
STC1Uncharacterized protein. (375 aa)
ENSMMUP00000078548ANK_REP_REGION domain-containing protein. (299 aa)
HLXH2.0 like homeobox. (495 aa)
ENSMMUP00000080620Uncharacterized protein. (640 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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