(41 nodes) Non-canonical Wnt signaling pathway network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRICKLE2	Prickle-like protein 2. (844 aa)
	GPC4	Glypican-4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
	FZD4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	GRHL3	Grainyhead like transcription factor 3. (626 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
	DVL3	Segment polarity protein dishevelled homolog DVL-3. (716 aa)
	FZD10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
	VANGL1	Vang-like protein. (535 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
	MYOC	Myocilin. (491 aa)
	ARHGEF19	Rho guanine nucleotide exchange factor 19. (809 aa)
	CELSR3	Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family. (3312 aa)
	CELSR2	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2926 aa)
	SFRP2	Secreted frizzled-related protein 2. (295 aa)
	IFT80	Intraflagellar transport protein 80 homolog isoform a. (777 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	NLK	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (243 aa)
	VANGL2	Vang-like protein. (521 aa)
	CELSR1	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (1818 aa)
	DAAM1	Disheveled-associated activator of morphogenesis 1. (1078 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
	SFRP1	Secreted frizzled-related protein 1. (314 aa)
	PTK7	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (848 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (597 aa)
	DVL1	Dishevelled segment polarity protein 1. (695 aa)
	MED12	Mediator complex subunit 12. (2178 aa)
	MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1452 aa)
	TIAM1	Uncharacterized protein. (1591 aa)
	RYK	Receptor like tyrosine kinase. (611 aa)
	DVL2	Dishevelled segment polarity protein 2. (767 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
	FZD3	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	SMURF1	E3 ubiquitin-protein ligase. (757 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
	SMURF2	E3 ubiquitin-protein ligase. (748 aa)
	CCDC88C	Coiled-coil domain containing 88C. (2028 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF19	DAAM1	ENSMMUP00000018930	ENSMMUP00000027734	Rho guanine nucleotide exchange factor 19.	Disheveled-associated activator of morphogenesis 1.	0.501
CCDC88C	DVL1	ENSMMUP00000078985	ENSMMUP00000046582	Coiled-coil domain containing 88C.	Dishevelled segment polarity protein 1.	0.694
CELSR1	DAAM1	ENSMMUP00000027625	ENSMMUP00000027734	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Disheveled-associated activator of morphogenesis 1.	0.447
CELSR1	DVL1	ENSMMUP00000027625	ENSMMUP00000046582	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Dishevelled segment polarity protein 1.	0.418
CELSR1	DVL2	ENSMMUP00000027625	ENSMMUP00000061251	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Dishevelled segment polarity protein 2.	0.419
CELSR1	FZD3	ENSMMUP00000027625	ENSMMUP00000065802	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.624
CELSR1	FZD6	ENSMMUP00000027625	ENSMMUP00000032022	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.831
CELSR1	PRICKLE1	ENSMMUP00000027625	ENSMMUP00000039937	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Prickle planar cell polarity protein 1.	0.676
CELSR1	PRICKLE2	ENSMMUP00000027625	ENSMMUP00000002011	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Prickle-like protein 2.	0.737
CELSR1	PTK7	ENSMMUP00000027625	ENSMMUP00000033655	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.549
CELSR1	RYK	ENSMMUP00000027625	ENSMMUP00000060672	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Receptor like tyrosine kinase.	0.515
CELSR1	VANGL1	ENSMMUP00000027625	ENSMMUP00000011750	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Vang-like protein.	0.847
CELSR1	VANGL2	ENSMMUP00000027625	ENSMMUP00000026708	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Vang-like protein.	0.840
CELSR2	FZD3	ENSMMUP00000020161	ENSMMUP00000065802	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.481
CELSR2	FZD6	ENSMMUP00000020161	ENSMMUP00000032022	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.538
CELSR2	PRICKLE1	ENSMMUP00000020161	ENSMMUP00000039937	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Prickle planar cell polarity protein 1.	0.583
CELSR2	PRICKLE2	ENSMMUP00000020161	ENSMMUP00000002011	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Prickle-like protein 2.	0.714
CELSR2	PTK7	ENSMMUP00000020161	ENSMMUP00000033655	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.476
CELSR2	RYK	ENSMMUP00000020161	ENSMMUP00000060672	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Receptor like tyrosine kinase.	0.455
CELSR2	VANGL1	ENSMMUP00000020161	ENSMMUP00000011750	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Vang-like protein.	0.768