STRINGSTRING
BIRC2 BIRC2 CD40 CD40 TRAF2 TRAF2 TRAF6 TRAF6 IKBKB IKBKB TRAF5 TRAF5 CHUK CHUK TRAF3 TRAF3 HTRA2 HTRA2 RNF31 RNF31
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BIRC2Baculoviral IAP repeat-containing protein 2. (618 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform 1. (278 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
HTRA2Serine protease HTRA2, mitochondrial isoform 1 preproprotein. (458 aa)
RNF31Uncharacterized protein. (1146 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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