(21 nodes) Response to muscle stretch network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TTN	Titin. (32000 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	NPPA	Natriuretic peptide A. (153 aa)
	ANKRD23	Ankyrin repeat domain 23. (306 aa)
	ANKRD1	Ankyrin repeat domain 1. (318 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	RYR2	Ryanodine receptor 2. (4967 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (896 aa)
	NFKB1	Uncharacterized protein. (977 aa)
	SLC8A1	J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (334 aa)
	FOS	V-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
	CSRP3	Cysteine and glycine rich protein 3. (253 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (544 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (317 aa)
	GSN	Gelsolin. (809 aa)
	DMD	Uncharacterized protein. (3685 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD1	NPPA	ENSMMUP00000008715	ENSMMUP00000010290	Ankyrin repeat domain 1.	Natriuretic peptide A.	0.451
ANKRD1	RYR2	ENSMMUP00000008715	ENSMMUP00000001421	Ankyrin repeat domain 1.	Ryanodine receptor 2.	0.478
ANKRD1	TTN	ENSMMUP00000008715	ENSMMUP00000011868	Ankyrin repeat domain 1.	Titin.	0.701
ANKRD23	TTN	ENSMMUP00000009970	ENSMMUP00000011868	Ankyrin repeat domain 23.	Titin.	0.608
CAV3	CTNNB1	ENSMMUP00000061270	ENSMMUP00000062910	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Catenin beta-1.	0.667
CAV3	DMD	ENSMMUP00000061270	ENSMMUP00000016336	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.625
CAV3	RYR2	ENSMMUP00000061270	ENSMMUP00000001421	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Ryanodine receptor 2.	0.402
CSRP3	NPPA	ENSMMUP00000067509	ENSMMUP00000010290	Cysteine and glycine rich protein 3.	Natriuretic peptide A.	0.434
CSRP3	TTN	ENSMMUP00000067509	ENSMMUP00000011868	Cysteine and glycine rich protein 3.	Titin.	0.737
CTNNB1	CAV3	ENSMMUP00000062910	ENSMMUP00000061270	Catenin beta-1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.667
CTNNB1	JUN	ENSMMUP00000062910	ENSMMUP00000074392	Catenin beta-1.	Transcription factor AP-1; Belongs to the bZIP family.	0.649
CTNNB1	MAPK14	ENSMMUP00000062910	ENSMMUP00000011075	Catenin beta-1.	Mitogen-activated protein kinase.	0.620
CTNNB1	NFKB1	ENSMMUP00000062910	ENSMMUP00000034946	Catenin beta-1.	Uncharacterized protein.	0.727
CTNNB1	PIK3CA	ENSMMUP00000062910	ENSMMUP00000006866	Catenin beta-1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.589
CTNNB1	PTK2	ENSMMUP00000062910	ENSMMUP00000049969	Catenin beta-1.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.459
CTNNB1	RELA	ENSMMUP00000062910	ENSMMUP00000054901	Catenin beta-1.	RELA proto-oncogene, NF-kB subunit.	0.613
DDR2	PIK3CA	ENSMMUP00000041768	ENSMMUP00000006866	Discoidin domain receptor tyrosine kinase 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.450
DMD	CAV3	ENSMMUP00000016336	ENSMMUP00000061270	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.625
DMD	TTN	ENSMMUP00000016336	ENSMMUP00000011868	Uncharacterized protein.	Titin.	0.661
FOS	JUN	ENSMMUP00000071593	ENSMMUP00000074392	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	Transcription factor AP-1; Belongs to the bZIP family.	0.999