STRINGSTRING
POLN POLN RNF168 RNF168 NEIL3 NEIL3 SLX4 SLX4 ATR ATR RFWD3 RFWD3 FANCI FANCI XPA XPA RAD51AP1 RAD51AP1 ERCC4 ERCC4 FANCE FANCE FANCM FANCM DCLRE1A DCLRE1A FANCB FANCB FAAP24 FAAP24 FAAP20 FAAP20 DCLRE1B DCLRE1B VCP VCP FANCF FANCF XRCC3 XRCC3 MCM9 MCM9 RAD51 RAD51 FANCA FANCA ERCC1 ERCC1 FANCL FANCL FANCD2 FANCD2 CENPX CENPX NUCKS1 NUCKS1 RAD51AP2 RAD51AP2 EXO5 EXO5 FANCC FANCC HROB HROB ERCC6L2 ERCC6L2 FAN1 FAN1 FAAP100 FAAP100
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLNDNA polymerase nu. (900 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (661 aa)
NEIL3Nei like DNA glycosylase 3. (602 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1668 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
RFWD3Ring finger and WD repeat domain 3. (774 aa)
FANCIFA complementation group I. (1328 aa)
XPAXPA, DNA damage recognition and repair factor. (294 aa)
RAD51AP1RAD51 associated protein 1. (352 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
FANCEFA complementation group E. (536 aa)
FANCMFA complementation group M. (2050 aa)
DCLRE1ADNA cross-link repair 1A. (1039 aa)
FANCBFA complementation group B. (858 aa)
FAAP24Fanconi anemia-associated protein of 24 kDa. (215 aa)
FAAP20FA core complex associated protein 20. (186 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
VCPUncharacterized protein; Belongs to the AAA ATPase family. (823 aa)
FANCFFanconi anemia group F protein. (374 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (380 aa)
FANCAFA complementation group A. (1462 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (442 aa)
FANCLFA complementation group L. (531 aa)
FANCD2Uncharacterized protein. (1471 aa)
CENPXUncharacterized protein. (201 aa)
NUCKS1Uncharacterized protein. (248 aa)
RAD51AP2RAD51 associated protein 2. (1150 aa)
EXO5Exonuclease 5. (373 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (578 aa)
HROBChromosome 16 C17orf53 homolog. (664 aa)
ERCC6L2Uncharacterized protein. (1551 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
FAAP100Fanconi anemia-associated protein of 100 kDa isoform b. (881 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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