121 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AXIN1	Axin 1. (867 aa)
	SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
	BMI1	RING-type domain-containing protein. (469 aa)
	SUZ12	SUZ12 polycomb repressive complex 2 subunit. (739 aa)
	LOC695427-2	Histone H3; Belongs to the histone H3 family. (136 aa)
	PADI2	Peptidyl arginine deiminase 2. (687 aa)
	FAM172A	Family with sequence similarity 172 member A. (466 aa)
	ARID1B	AT-rich interaction domain 1B. (2428 aa)
	TASOR	Transcription activation suppressor. (1612 aa)
	ARID4A	AT-rich interactive domain-containing protein 4A isoform I. (1257 aa)
	LHX2	LIM/homeobox protein Lhx2. (406 aa)
	MNDA	Gamma-interferon-inducible protein 16 isoform 2. (729 aa)
	CENPV	Centromere protein V. (274 aa)
	CDYL	Chromodomain Y-like protein isoform a. (545 aa)
	NDN	Necdin. (321 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1084 aa)
	H2AFY	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
	SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (603 aa)
	LOC695847	Uncharacterized protein. (183 aa)
	ARID4B	AT-rich interaction domain 4B. (1318 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (456 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
	PHF2	PHD finger protein 2. (1102 aa)
	TFAP2C	Transcription factor AP-2 gamma. (450 aa)
	WBP2	WW domain binding protein 2. (379 aa)
	CTCF	Transcriptional repressor CTCF isoform 1. (727 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	GLMN	Glomulin, FKBP associated protein. (594 aa)
	SMYD5	SMYD family member 5. (418 aa)
	ARID1A	AT-rich interaction domain 1A. (2287 aa)
	H1-8	H1 histone family member O oocyte specific. (334 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)
	PABPC1L	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (614 aa)
	ZNF335	Zinc finger protein 335. (1346 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1717 aa)
	METTL3	N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (580 aa)
	RBM15	RNA binding motif protein 15. (925 aa)
	KMT2D	Lysine methyltransferase 2D. (5578 aa)
	HDAC6	UBP-type domain-containing protein. (1257 aa)
	MPHOSPH8	M-phase phosphoprotein 8. (859 aa)
	CREBZF	CREB/ATF bZIP transcription factor. (356 aa)
	NRM	Nurim. (262 aa)
	HELLS	Uncharacterized protein. (883 aa)
	MTA1	Metastasis associated 1. (726 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa)
	TNP1	Transition protein 1. (55 aa)
	SPTY2D1	SPT2 chromatin protein domain containing 1. (684 aa)
	BAZ2A	Bromodomain adjacent to zinc finger domain 2A. (1910 aa)
	SIRT6	NAD-dependent deacetylase sirtuin-6. (355 aa)
	MBD3L1	Methyl-CpG binding domain protein 3 like 1. (195 aa)
	TDG	Thymine DNA glycosylase. (410 aa)
	SPHK2	DAGKc domain-containing protein. (669 aa)
	KDM1B	Lysine demethylase 1B. (822 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa)
	SIRT1	Sirtuin 1. (743 aa)
	CHEK1	STT3 oligosaccharyltransferase complex catalytic subunit A. (768 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (825 aa)
	HAT1	Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
	LMNA	Prelamin-A/C isoform 1; Belongs to the intermediate filament family. (663 aa)
	CENPVL3	GFA domain-containing protein. (287 aa)
	MBD2	Methyl-CpG binding domain protein 2. (412 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1281 aa)
	PPHLN1	Periphilin 1. (464 aa)
	PCGF5	Polycomb group ring finger 5. (261 aa)
	CTCFL	CCCTC-binding factor like. (702 aa)
	MBD3	Methyl-CpG-binding domain protein 3. (291 aa)
	HMGA2	High mobility group AT-hook 2. (147 aa)
	RB1	Retinoblastoma-associated protein. (928 aa)
	DOT1L	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1774 aa)
	TRIM27	Zinc finger protein RFP. (513 aa)
	ZDBF2	Zinc finger DBF-type containing 2. (2357 aa)
	KLF2	Kruppel like factor 2. (355 aa)
	STBD1	Uncharacterized protein. (424 aa)
	YTHDC1	YTH domain-containing protein 1 isoform 2. (710 aa)
	CBX3	Chromobox protein homolog 3. (183 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
	LMNB1	Lamin-B1 isoform 1; Belongs to the intermediate filament family. (586 aa)
	ZFP57	ZFP57 zinc finger protein. (535 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (832 aa)
	KAT2B	Lysine acetyltransferase 2B. (866 aa)
	SMCHD1	Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (2005 aa)
	RLIM	E3 ubiquitin-protein ligase RLIM. (624 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1123 aa)
	HIST1H3D	Histone cluster 1, H3d. (136 aa)
	MORC2	MORC family CW-type zinc finger 2. (1085 aa)
	VPS72	Vacuolar protein sorting-associated protein 72 homolog. (364 aa)
	BEND3	BEN domain containing 3. (828 aa)
	RIF1	Replication timing regulatory factor 1. (2466 aa)
	H3C8	H3 clustered histone 8. (136 aa)
	PCGF3	RING-type domain-containing protein. (265 aa)
	ENSMMUP00000065918	Uncharacterized protein. (117 aa)
	ENSMMUP00000066392	annotation not available (136 aa)
	ENSMMUP00000066500	Uncharacterized protein. (236 aa)
	LOC698105	Histone H3.1. (136 aa)
	LOC717718	GFA domain-containing protein. (272 aa)
	ENSMMUP00000067976	Uncharacterized protein. (120 aa)
	ENSMMUP00000068054	Uncharacterized protein. (102 aa)
	ENSMMUP00000068277	Histone H3; Belongs to the histone H3 family. (136 aa)
	ZNFX1	NFX1-type zinc finger-containing protein 1. (1918 aa)
	ENSMMUP00000070232	Uncharacterized protein. (121 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (628 aa)
	LOC703889	Histone H3.1. (136 aa)
	BAHD1	BAH domain-containing protein. (860 aa)
	H2AFY2	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	CMC4	Uncharacterized protein. (92 aa)
	EXOSC10	Exosome component 10. (928 aa)
	DRAM2	Ligand dependent nuclear receptor interacting factor 1. (760 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
	ENSMMUP00000075843	Uncharacterized protein. (341 aa)
	LOC100430668	Histone H3.1. (136 aa)
	EP300	Histone acetyltransferase p300. (2414 aa)
	ASIP	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). (132 aa)
	ENSMMUP00000077734	Uncharacterized protein. (122 aa)
	PRDM14	PR domain-containing protein 14. (571 aa)
	EPC1	Enhancer of polycomb homolog. (836 aa)
	CTBP1	C-terminal-binding protein 1 isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
	PRMT7	Protein arginine methyltransferase 7; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (783 aa)
	CGGBP1	CGG triplet repeat-binding protein 1. (167 aa)
	ENSMMUP00000080573	Uncharacterized protein. (121 aa)
	LOC695427	Histone H3.1. (136 aa)
	ENSMMUP00000080739	Uncharacterized protein. (465 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID1A	ARID1B	ENSMMUP00000016675	ENSMMUP00000003037	AT-rich interaction domain 1A.	AT-rich interaction domain 1B.	0.985
ARID1A	BRCA1	ENSMMUP00000016675	ENSMMUP00000034386	AT-rich interaction domain 1A.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.461
ARID1A	EP300	ENSMMUP00000016675	ENSMMUP00000076664	AT-rich interaction domain 1A.	Histone acetyltransferase p300.	0.547
ARID1A	EZH2	ENSMMUP00000016675	ENSMMUP00000060546	AT-rich interaction domain 1A.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.526
ARID1A	KMT2D	ENSMMUP00000016675	ENSMMUP00000020643	AT-rich interaction domain 1A.	Lysine methyltransferase 2D.	0.528
ARID1A	SMARCD1	ENSMMUP00000016675	ENSMMUP00000008601	AT-rich interaction domain 1A.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1.	0.979
ARID1B	ARID1A	ENSMMUP00000003037	ENSMMUP00000016675	AT-rich interaction domain 1B.	AT-rich interaction domain 1A.	0.985
ARID1B	EP300	ENSMMUP00000003037	ENSMMUP00000076664	AT-rich interaction domain 1B.	Histone acetyltransferase p300.	0.456
ARID1B	SMARCD1	ENSMMUP00000003037	ENSMMUP00000008601	AT-rich interaction domain 1B.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1.	0.939
ARID4A	ARID4B	ENSMMUP00000004681	ENSMMUP00000009358	AT-rich interactive domain-containing protein 4A isoform I.	AT-rich interaction domain 4B.	0.782
ARID4A	ENSMMUP00000066392	ENSMMUP00000004681	ENSMMUP00000066392	AT-rich interactive domain-containing protein 4A isoform I.	annotation not available	0.663
ARID4A	ENSMMUP00000068277	ENSMMUP00000004681	ENSMMUP00000068277	AT-rich interactive domain-containing protein 4A isoform I.	Histone H3; Belongs to the histone H3 family.	0.663
ARID4A	EPC1	ENSMMUP00000004681	ENSMMUP00000078687	AT-rich interactive domain-containing protein 4A isoform I.	Enhancer of polycomb homolog.	0.662
ARID4A	EZH2	ENSMMUP00000004681	ENSMMUP00000060546	AT-rich interactive domain-containing protein 4A isoform I.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.408
ARID4A	GPX1	ENSMMUP00000004681	ENSMMUP00000017012	AT-rich interactive domain-containing protein 4A isoform I.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.441
ARID4A	H3C8	ENSMMUP00000004681	ENSMMUP00000064058	AT-rich interactive domain-containing protein 4A isoform I.	H3 clustered histone 8.	0.663
ARID4A	HDAC1	ENSMMUP00000004681	ENSMMUP00000013015	AT-rich interactive domain-containing protein 4A isoform I.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.933
ARID4A	HDAC4	ENSMMUP00000004681	ENSMMUP00000007984	AT-rich interactive domain-containing protein 4A isoform I.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.795
ARID4A	HDAC5	ENSMMUP00000004681	ENSMMUP00000061782	AT-rich interactive domain-containing protein 4A isoform I.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.795
ARID4A	HDAC6	ENSMMUP00000004681	ENSMMUP00000021637	AT-rich interactive domain-containing protein 4A isoform I.	UBP-type domain-containing protein.	0.798