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| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | BCL6 | Uncharacterized protein. (735 aa) |
| | TNFSF18 | Tumor necrosis factor ligand 2A. (199 aa) |
| | CD276 | CD276 molecule. (613 aa) |
| | IL27 | Interleukin 27 alpha. (254 aa) |
| | LOC114672614 | Uncharacterized protein. (137 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | GPNMB | PKD domain-containing protein. (556 aa) |
| | KITLG | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (283 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | VCAM1 | Vascular cell adhesion molecule 1. (739 aa) |
| | CD209 | CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (444 aa) |
| | LRRC32 | Leucine rich repeat containing 32. (662 aa) |
| | ZAP70 | Tyrosine-protein kinase. (619 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (739 aa) |
| | CD1D | Ig-like domain-containing protein. (337 aa) |
| | HHLA2 | HERV-H LTR-associating 2. (415 aa) |
| | MAMU-DPA | MHC class II antigen; Belongs to the MHC class II family. (260 aa) |
| | LMO3 | Uncharacterized protein. (187 aa) |
| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | IL15 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (162 aa) |
| | AGER | Uncharacterized protein. (403 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | LOC100427967 | Galectin. (355 aa) |
| | EGK_20852 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | VTCN1 | V-set domain containing T cell activation inhibitor 1. (282 aa) |
| | DHPS | Deoxyhypusine synthase isoform a. (369 aa) |
| | TNFRSF9 | Tumor necrosis factor receptor superfamily member 9. (254 aa) |
| | SPN | Sialophorin. (547 aa) |
| | CTLA4 | Cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM. (223 aa) |
| | SLAMF1 | Signaling lymphocytic activation molecule family member 1. (356 aa) |
| | PAWR | Pro-apoptotic WT1 regulator. (341 aa) |
| | JAK2 | Tyrosine-protein kinase. (1137 aa) |
| | CR1 | Complement C3b/C4b receptor 1 (Knops blood group). (2041 aa) |
| | ITCH | E3 ubiquitin-protein ligase. (918 aa) |
| | IL12RB1 | Interleukin 12 receptor subunit beta 1. (789 aa) |
| | IL4I1 | Amine oxidase. (589 aa) |
| | CD70 | CD70 molecule; Belongs to the tumor necrosis factor family. (316 aa) |
| | JAK3 | Janus kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (602 aa) |
| | ICOSLG | Uncharacterized protein. (305 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (626 aa) |
| | GLMN | Glomulin, FKBP associated protein. (594 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | SPTA1 | Spectrin alpha, erythrocytic 1. (2420 aa) |
| | TRIM2 | Transmembrane 131 like. (1724 aa) |
| | FOXP3 | Forkhead box P3. (539 aa) |
| | STAT5B | Signal transducer and activator of transcription. (787 aa) |
| | RASAL3 | RAS protein activator like 3. (1132 aa) |
| | MAPK8IP1 | Mitogen-activated protein kinase 8 interacting protein 1. (755 aa) |
| | IGF1 | Insulin like growth factor 1. (208 aa) |
| | TFRC | Transferrin receptor protein 1. (760 aa) |
| | ZP4 | Zona pellucida glycoprotein 4. (538 aa) |
| | TNFSF9 | TNF superfamily member 9; Belongs to the tumor necrosis factor family. (251 aa) |
| | IL6ST | Uncharacterized protein. (942 aa) |
| | IHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa) |
| | IL12RB2 | Interleukin 12 receptor subunit beta 2. (863 aa) |
| | IL23R | Interleukin 23 receptor. (629 aa) |
| | RC3H1 | Ring finger and CCCH-type domains 1. (1133 aa) |
| | PTEN | Uncharacterized protein. (589 aa) |
| | DNAJA3 | DnaJ heat shock protein family (Hsp40) member A3. (480 aa) |
| | IL20RB | Fibronectin type-III domain-containing protein. (311 aa) |
| | DLG5 | Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1948 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | EFNB1 | EPH-related receptor tyrosine kinase ligand 2; Belongs to the ephrin family. (346 aa) |
| | NCKAP1L | NCK associated protein 1 like. (1134 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (501 aa) |
| | BMP4 | Bone morphogenetic protein 4. (408 aa) |
| | ARG2 | Arginase. (417 aa) |
| | NDFIP1 | Uncharacterized protein. (228 aa) |
| | LILRB4 | Leukocyte immunoglobulin like receptor B4. (423 aa) |
| | VSIG4 | V-set and immunoglobulin domain containing 4. (404 aa) |
| | IGF2 | Insulin like growth factor 2. (244 aa) |
| | ARG1 | Arginase. (322 aa) |
| | CD80 | CD80 molecule. (288 aa) |
| | AIF1 | Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). (147 aa) |
| | LOC705334 | Uncharacterized protein. (205 aa) |
| | CD81 | Tetraspanin. (274 aa) |
| | CRTAM | Cytotoxic and regulatory T cell molecule. (401 aa) |
| | TWSG1 | Twisted gastrulation protein-like protein 1. (223 aa) |
| | LOC114669810 | Ig-like domain-containing protein; Belongs to the MHC class II family. (266 aa) |
| | ENSMMUP00000073450 | Ig-like domain-containing protein; Belongs to the MHC class I family. (369 aa) |
| | PYCARD | Apoptosis-associated speck-like protein containing a CARD isoform a. (195 aa) |
| | ENSMMUP00000072696 | Uncharacterized protein. (103 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | CBLB | Cbl proto-oncogene B. (982 aa) |
| | MARCHF7 | Membrane associated ring-CH-type finger 7. (704 aa) |
| | FOXJ1 | Forkhead box J1. (421 aa) |
| | SDC4 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa) |
| | CLEC4G | C-type lectin domain family 4 member G. (293 aa) |
| | ENSMMUP00000068350 | MHC_II_beta domain-containing protein. (103 aa) |
| | VSIR | V-set immunoregulatory receptor. (311 aa) |
| | SLC7A1 | High affinity cationic amino acid transporter 1. (629 aa) |
| | PDCD1LG2 | Programmed cell death 1 ligand 2. (273 aa) |
| | IGFBP2 | Insulin like growth factor binding protein 2. (325 aa) |
| | TYK2 | Tyrosine-protein kinase. (1196 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa) |
| | ENSMMUP00000066266 | Uncharacterized protein. (188 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (718 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa) |
| | CD28 | T-cell-specific surface glycoprotein CD28. (220 aa) |
| | NCK1 | Cytoplasmic protein. (377 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (271 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1437 aa) |
| | TNFRSF13C | TNF receptor superfamily member 13C. (184 aa) |
| | PRNP | Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (253 aa) |
| | ANXA1 | Annexin. (367 aa) |
| | LGALS3 | Galectin. (248 aa) |
| | IL21 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | LOC694781 | Galectin. (136 aa) |
| | CD6 | Uncharacterized protein. (782 aa) |
| | CTNNB1 | Catenin beta-1. (781 aa) |
| | CD3E | CD3e molecule. (217 aa) |
| | LMO1 | LIM domain only 1. (156 aa) |
| | LOC114669853 | Tyrosine-protein kinase. (1125 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | CARD11 | Caspase recruitment domain family member 11. (1154 aa) |
| | LOC114674161 | Galectin. (136 aa) |
| | CORO1A | Coronin; Belongs to the WD repeat coronin family. (461 aa) |
| | TNFSF8 | Tumor necrosis factor ligand superfamily member 8; Belongs to the tumor necrosis factor family. (234 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (547 aa) |
| | RAC2 | Ras-related C3 botulinum toxin substrate 2. (192 aa) |
| | IL27RA | Interleukin 27 receptor subunit alpha. (641 aa) |
| | TMIGD2 | Transmembrane and immunoglobulin domain containing 2. (302 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1310 aa) |
| | LRRC1 | Leucine-rich repeat-containing protein 1. (524 aa) |
| | PTPN22 | Protein tyrosine phosphatase non-receptor type 22. (813 aa) |
| | ENSMMUP00000052502 | Uncharacterized protein. (96 aa) |
| | CD86 | CD86 molecule. (417 aa) |
| | TNFSF4 | Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (344 aa) |
| | CD55 | Uncharacterized protein. (566 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa) |
| | SCRIB | Scribble planar cell polarity protein. (1451 aa) |
| | SOS2 | Uncharacterized protein. (1332 aa) |
| | IRF1 | Interferon regulatory factor. (325 aa) |
| | CCDC88B | Coiled-coil domain containing 88B. (1486 aa) |
| | PLA2G2D | Phospholipase A(2). (161 aa) |
| | CD40LG | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa) |
| | TNFRSF14 | TNF receptor superfamily member 14. (359 aa) |
| | IL23A | Interleukin-23 subunit alpha. (189 aa) |
| | CD274 | CD274 molecule. (299 aa) |
| | ZBTB7B | Zinc finger and BTB domain containing 7B. (636 aa) |
| | DLG1 | Disks large homolog 1 isoform 2; Belongs to the MAGUK family. (926 aa) |
| | TSPAN32 | Tetraspanin 32. (439 aa) |
| | SCGB1A1 | Secretoglobin family 1A member 1. (91 aa) |
| | RPS3 | 40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | NCK2 | Cytoplasmic protein. (393 aa) |
| | TNFSF13B | TNF-and APOL-related leukocyte expressed ligand 1; Belongs to the tumor necrosis factor family. (285 aa) |
| | LOC106993942 | Galectin. (356 aa) |
| | SH3RF1 | SH3 domain containing ring finger 1. (888 aa) |
| | TNFRSF21 | Tumor necrosis factor receptor superfamily member 21. (655 aa) |
| | IDO1 | Indoleamine 2,3-dioxygenase 1. (403 aa) |
| | PDE5A | Phosphodiesterase. (875 aa) |
| | BID | BH3 interacting domain death agonist. (310 aa) |
| | HAVCR2 | Hepatitis A virus cellular receptor 2. (294 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa) |
