(54 nodes) Regulation of protein import into nucleus network (Macaca mulatta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	BAG3	Uncharacterized protein. (575 aa)
	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (500 aa)
	ZIC1	Zic family member 1. (447 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
	NF1	Neurofibromin 1. (2867 aa)
	XBP1	X-box binding protein 1. (376 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (601 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	CDH1	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	JUP	Uncharacterized protein. (744 aa)
	IPO5	Importin 5. (1097 aa)
	HCLS1	SH3 domain-containing protein. (551 aa)
	FLNA	Filamin-A isoform 2. (2647 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	CHP1	Uncharacterized protein. (196 aa)
	MAVS	Mitochondrial antiviral-signaling protein isoform 1. (541 aa)
	ANGPT1	Angiopoietin-1 isoform 1. (498 aa)
	NUP58	Nucleoporin 58. (665 aa)
	SIRT6	NAD-dependent deacetylase sirtuin-6. (355 aa)
	TRIM28	Tripartite motif containing 28. (834 aa)
	ZPR1	ZPR1 zinc finger. (459 aa)
	RBM22	Pre-mRNA-splicing factor RBM22. (420 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2806 aa)
	NUP54	Nucleoporin 54. (562 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	FERMT1	Fermitin family member 1. (677 aa)
	ECT2	Epithelial cell transforming 2. (958 aa)
	DMAP1	DNA methyltransferase 1 associated protein 1. (612 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	SUMO1	Small ubiquitin-related modifier. (101 aa)
	PTPN22	Protein tyrosine phosphatase non-receptor type 22. (813 aa)
	NOLC1	Nucleolar and coiled-body phosphoprotein 1. (702 aa)
	PKIG	cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
	MDFIC	MyoD family inhibitor domain containing. (246 aa)
	APOD	Apolipoprotein D. (189 aa)
	CABP1	Calcium binding protein 1. (708 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
	EPM2A	EPM2A glucan phosphatase, laforin. (331 aa)
	PGM1	Uncharacterized protein. (1085 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	CHP2	Hepatocellular carcinoma-associated antigen 520. (196 aa)
	TPR	TPR_MLP1_2 domain-containing protein. (2404 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	HYAL2	Hyaluronidase. (473 aa)
	PRKCD	Protein kinase C. (729 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	RAB23	Ras-related protein Rab-23. (237 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPT1	PIK3R2	ENSMMUP00000023343	ENSMMUP00000004228	Angiopoietin-1 isoform 1.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.525
BAG3	FLNA	ENSMMUP00000001088	ENSMMUP00000017986	Uncharacterized protein.	Filamin-A isoform 2.	0.456
BAG3	SMAD3	ENSMMUP00000001088	ENSMMUP00000041841	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.405
BMP4	SHH	ENSMMUP00000077296	ENSMMUP00000065431	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.747
BMP4	SMAD3	ENSMMUP00000077296	ENSMMUP00000041841	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.651
BMP4	SMO	ENSMMUP00000077296	ENSMMUP00000015878	Bone morphogenetic protein 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.478
CD36	IFNG	ENSMMUP00000072954	ENSMMUP00000065064	CD36 molecule; Belongs to the CD36 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.497
CD36	LEP	ENSMMUP00000072954	ENSMMUP00000007035	CD36 molecule; Belongs to the CD36 family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.470
CDH1	HCLS1	ENSMMUP00000015550	ENSMMUP00000017812	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	SH3 domain-containing protein.	0.452
CDH1	JUP	ENSMMUP00000015550	ENSMMUP00000017143	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.995
CDH1	PSEN1	ENSMMUP00000015550	ENSMMUP00000032752	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.746
CDH1	TGFB1	ENSMMUP00000015550	ENSMMUP00000031221	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.486
CHP1	HYAL2	ENSMMUP00000022485	ENSMMUP00000075793	Uncharacterized protein.	Hyaluronidase.	0.431
DMAP1	IPO5	ENSMMUP00000040336	ENSMMUP00000017795	DNA methyltransferase 1 associated protein 1.	Importin 5.	0.420
FERMT1	JUP	ENSMMUP00000037513	ENSMMUP00000017143	Fermitin family member 1.	Uncharacterized protein.	0.576
FLNA	BAG3	ENSMMUP00000017986	ENSMMUP00000001088	Filamin-A isoform 2.	Uncharacterized protein.	0.456
FLNA	HCLS1	ENSMMUP00000017986	ENSMMUP00000017812	Filamin-A isoform 2.	SH3 domain-containing protein.	0.468
GLI3	RAB23	ENSMMUP00000067447	ENSMMUP00000077696	GLI family zinc finger 3.	Ras-related protein Rab-23.	0.505
GLI3	SHH	ENSMMUP00000067447	ENSMMUP00000065431	GLI family zinc finger 3.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.841
GLI3	SMO	ENSMMUP00000067447	ENSMMUP00000015878	GLI family zinc finger 3.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.895