STRINGSTRING
SCP2 SCP2 AKR1C2 AKR1C2 CYP46A1 CYP46A1 CYP17A1 CYP17A1 AFP AFP AKR1C1 AKR1C1 DHRS9 DHRS9 STAT5B STAT5B STARD3 STARD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCP2Non-specific lipid-transfer protein isoform 1 proprotein; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
AKR1C2Aldo_ket_red domain-containing protein. (323 aa)
CYP46A1Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (583 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (536 aa)
AFPAlpha fetoprotein. (609 aa)
AKR1C1Aldo_ket_red domain-containing protein. (323 aa)
DHRS9Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (378 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
STARD3StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (By similarity). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (By similarity). May also mediate cholesterol transport between other membra [...] (445 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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