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| | BCL10 | BCL10 immune signaling adaptor. (233 aa) |
| | LURAP1 | NF-kappa-B activator C1orf190. (239 aa) |
| | FYN | Tyrosine-protein kinase. (589 aa) |
| | PELI2 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa) |
| | TMEM106A | Uncharacterized protein. (262 aa) |
| | INAVA | Innate immunity activator. (703 aa) |
| | S100B | Protein S100; Belongs to the S-100 family. (92 aa) |
| | TRIM32 | E3 ubiquitin-protein ligase TRIM32. (653 aa) |
| | ENSMMUP00000078044 | Uncharacterized protein. (84 aa) |
| | NDFIP1 | Uncharacterized protein. (228 aa) |
| | S100A12 | S100 calcium binding protein A12; Belongs to the S-100 family. (90 aa) |
| | LITAF | Lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 1. (161 aa) |
| | TRIM21 | E3 ubiquitin-protein ligase TRIM21. (475 aa) |
| | UBD | Ubiquitin D. (165 aa) |
| | RNF31 | Uncharacterized protein. (1146 aa) |
| | BIRC2 | Baculoviral IAP repeat-containing protein 2. (618 aa) |
| | CANT1 | Calcium activated nucleotidase 1. (450 aa) |
| | DDX21 | Nucleolar RNA helicase 2. (783 aa) |
| | CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | CX3CL1 | C-X3-C motif chemokine ligand 1. (407 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (308 aa) |
| | NDFIP2 | Nedd4 family interacting protein 2. (359 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | TIRAP | Toll/interleukin-1 receptor domain-containing adapter protein isoform a. (220 aa) |
| | CCL21 | C-C motif chemokine 21; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity). (131 aa) |
| | MUL1 | Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa) |
| | UNC5CL | Unc-5 family C-terminal like. (518 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa) |
| | TMEM9B | TMEM9 domain family member B. (198 aa) |
| | S100A13 | S100 calcium binding protein A13; Belongs to the S-100 family. (73 aa) |
| | TRIM13 | Tripartite motif containing 13. (406 aa) |
| | PIM2 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa) |
| | CASP1 | Caspase 1; Belongs to the peptidase C14A family. (462 aa) |
| | ENSMMUP00000066266 | Uncharacterized protein. (188 aa) |
| | UBE2I | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (260 aa) |
| | CCDC22 | Uncharacterized protein. (627 aa) |
| | CTNNB1 | Catenin beta-1. (781 aa) |
| | TRIM38 | Tripartite motif containing 38. (465 aa) |
| | RBCK1 | RanBP-type and C3HC4-type zinc finger-containing protein 1 isoform 2. (510 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | LOC106995642 | LITAF domain-containing protein. (160 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | CARD11 | Caspase recruitment domain family member 11. (1154 aa) |
| | TFG | Protein TFG isoform 1. (400 aa) |
| | ECM1 | Extracellular matrix protein 1 isoform 1. (540 aa) |
| | TRIM62 | Tripartite motif containing 62. (741 aa) |
| | AJUBA | Ajuba LIM protein. (538 aa) |
| | TAB3 | Mitogen-activated protein kinase kinase kinase 7-interacting protein 3. (712 aa) |
| | ANKRD17 | Ankyrin repeat domain 17. (2603 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | TRIM14 | Tripartite motif containing 14. (442 aa) |
| | DDX1 | ATP-dependent RNA helicase DDX1. (740 aa) |
| | GOLT1B | Uncharacterized protein. (155 aa) |
| | ADIPOQ | Adiponectin, C1Q and collagen domain containing. (274 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | PPM1A | Protein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa) |
| | F2R | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa) |
| | TMED4 | Endoplasmic reticulum stress-response protein 25. (227 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | PINK1 | Serine/threonine-protein kinase PINK1, mitochondrial. (581 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (210 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | TRIM27 | Zinc finger protein RFP. (513 aa) |
| | TRIM5 | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (496 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (520 aa) |
| | LTBR | Uncharacterized protein. (461 aa) |
| | CTH | Uncharacterized protein. (434 aa) |
| | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 isoform 1. (657 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1044 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (416 aa) |
| | MTDH | Metadherin. (612 aa) |
| | RHOA | Ras homolog family member A. (209 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | GPRC5B | G protein-coupled receptor class C group 5 member B. (404 aa) |
| | MID2 | Putative E3 ubiquitin-protein ligase MID2 isoform 1. (735 aa) |
| | TNIP2 | TNFAIP3 interacting protein 2. (468 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa) |
| | ECT2 | Epithelial cell transforming 2. (958 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (716 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (538 aa) |
| | EDAR | Ectodysplasin A receptor. (465 aa) |
| | TRIM52 | Tripartite motif containing 52. (276 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7. (620 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | CC2D1A | Coiled-coil and C2 domain containing 1A. (980 aa) |
| | PPP5C | Serine/threonine-protein phosphatase. (607 aa) |
| | NUP62 | Nuclear pore glycoprotein p62. (521 aa) |
| | TRIML2 | Tripartite motif family like 2. (437 aa) |
| | IRF3 | Interferon regulatory factor 3. (450 aa) |
| | TRIM68 | E3 ubiquitin-protein ligase TRIM68. (485 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | BRD4 | Bromodomain containing 4. (1334 aa) |
| | PLEKHG5 | Pleckstrin homology and RhoGEF domain containing G5. (1155 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (281 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (725 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | ZDHHC17 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (632 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member. (317 aa) |
| | EDA | Ectodysplasin A; Belongs to the tumor necrosis factor family. (391 aa) |
| | MAVS | Mitochondrial antiviral-signaling protein isoform 1. (541 aa) |
| | TRIML1 | Tripartite motif family like 1. (468 aa) |
| | TIFA | TRAF-interacting protein with FHA domain-containing protein A. (185 aa) |
| | EDA2R | Ectodysplasin A2 receptor. (318 aa) |
| | LAMTOR5 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (169 aa) |
| | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa) |
| | LTF | Lactotransferrin; Belongs to the transferrin family. (747 aa) |
| | MALT1 | MALT1 paracaspase. (824 aa) |
| | ALPK1 | Alpha kinase 1. (1245 aa) |
| | CLEC4D | C-type lectin domain family 4 member D. (215 aa) |
| | CLEC6A | C-type lectin domain containing 6A. (209 aa) |
| | FLNA | Filamin-A isoform 2. (2647 aa) |
| | TRIM6 | Uncharacterized protein. (559 aa) |
| | LURAP1L | Leucine rich adaptor protein 1 like. (254 aa) |
| | MIB2 | Mindbomb E3 ubiquitin protein ligase 2. (1013 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | HTR2B | 5-hydroxytryptamine receptor 2B. (481 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa) |
| | DHX36 | DEAH-box helicase 36. (1008 aa) |
| | AKAP13 | A-kinase anchoring protein 13. (2899 aa) |
| | S100A4 | Protein S100; Belongs to the S-100 family. (101 aa) |
| | REL | REL proto-oncogene, NF-kB subunit. (616 aa) |
| | LOC100426497 | Uncharacterized protein; Belongs to the peptidase C14A family. (174 aa) |
| | CARD17 | Caspase recruitment domain family member 17. (110 aa) |
| | TMEM101 | Putative NF-kappa-B-activating protein 130. (257 aa) |
| | DHX15 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15. (795 aa) |
| | CD74 | HLA class II histocompatibility antigen gamma chain isoform a. (294 aa) |
| | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase. (335 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (947 aa) |
| | TBK1 | Serine/threonine-protein kinase TBK1. (729 aa) |
| | NEK6 | NIMA related kinase 6; Belongs to the protein kinase superfamily. (397 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | SHARPIN | Sharpin. (382 aa) |
| | LPAR1 | Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa) |
| | BST2 | Bone marrow stromal cell antigen 2. (182 aa) |
| | TERF2IP | Telomeric repeat-binding factor 2-interacting protein 1. (400 aa) |
| | GJA1 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa) |
| | NEK11 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (955 aa) |
| | ROR1 | Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa) |
| | TRIM8 | Putative E3 ubiquitin-protein ligase TRIM8. (551 aa) |
| | TNFRSF19 | TNF receptor superfamily member 19. (417 aa) |
| | CD40 | Tumor necrosis factor receptor superfamily member 5 isoform 1. (278 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (535 aa) |
| | CLEC7A | C-type lectin domain family 7 member A; Lectin that functions as pattern receptor specific for beta- 1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). Necessary for the TLR2- mediated inflammatory response and for TLR2-mediated activation of NF- kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does [...] (281 aa) |
| | TRAF3IP2 | SEFIR domain-containing protein. (572 aa) |
| | TFRC | Transferrin receptor protein 1. (760 aa) |
| | CCR7 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa) |
| | JMJD8 | Jumonji domain containing 8. (285 aa) |
| | H9H2Q7_MACMU | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (364 aa) |
| | DDX50 | ATP-dependent RNA helicase DDX50. (737 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | TRIM22 | E3 ubiquitin-protein ligase TRIM22 isoform 1. (498 aa) |
| | IRAK4 | Interleukin-1 receptor-associated kinase 4. (460 aa) |
