(18 nodes) Surfactant homeostasis network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (335 aa)
	SFTPD	Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. (375 aa)
	LPCAT1	Lysophosphatidylcholine acyltransferase 1. (688 aa)
	NAPSA	Napsin A aspartic peptidase; Belongs to the peptidase A1 family. (420 aa)
	EPAS1	Endothelial PAS domain protein 1. (875 aa)
	ITGB6	Integrin beta; Belongs to the integrin beta chain family. (788 aa)
	RCN3	Uncharacterized protein. (326 aa)
	NKIRAS2	NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform a. (191 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
	OAS1	2'-5'-oligoadenylate synthetase 1. (488 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2595 aa)
	ABCA15	Uncharacterized protein. (182 aa)
	LOC719235	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (422 aa)
	ABCA3	ATP binding cassette subfamily A member 3. (1704 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	ADGRF5	Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1383 aa)
	LOC114669852	Uncharacterized protein. (328 aa)
	ENSMMUP00000079873	ABC transporter domain-containing protein. (155 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA15	ABCA3	ENSMMUP00000022037	ENSMMUP00000025287	Uncharacterized protein.	ATP binding cassette subfamily A member 3.	0.900
ABCA15	ENSMMUP00000079873	ENSMMUP00000022037	ENSMMUP00000079873	Uncharacterized protein.	ABC transporter domain-containing protein.	0.504
ABCA3	ABCA15	ENSMMUP00000025287	ENSMMUP00000022037	ATP binding cassette subfamily A member 3.	Uncharacterized protein.	0.900
ABCA3	LPCAT1	ENSMMUP00000025287	ENSMMUP00000075541	ATP binding cassette subfamily A member 3.	Lysophosphatidylcholine acyltransferase 1.	0.710
CTSH	LOC719235	ENSMMUP00000013201	ENSMMUP00000023897	Cathepsin H; Belongs to the peptidase C1 family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.610
CTSH	NAPSA	ENSMMUP00000013201	ENSMMUP00000074186	Cathepsin H; Belongs to the peptidase C1 family.	Napsin A aspartic peptidase; Belongs to the peptidase A1 family.	0.610
ENSMMUP00000079873	ABCA15	ENSMMUP00000079873	ENSMMUP00000022037	ABC transporter domain-containing protein.	Uncharacterized protein.	0.504
ITGB6	TGFB1	ENSMMUP00000053563	ENSMMUP00000031221	Integrin beta; Belongs to the integrin beta chain family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.906
KDR	TGFB1	ENSMMUP00000016642	ENSMMUP00000031221	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.424
LOC719235	CTSH	ENSMMUP00000023897	ENSMMUP00000013201	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Cathepsin H; Belongs to the peptidase C1 family.	0.610
LOC719235	NAPSA	ENSMMUP00000023897	ENSMMUP00000074186	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Napsin A aspartic peptidase; Belongs to the peptidase A1 family.	0.901
LPCAT1	ABCA3	ENSMMUP00000075541	ENSMMUP00000025287	Lysophosphatidylcholine acyltransferase 1.	ATP binding cassette subfamily A member 3.	0.710
LPCAT1	SFTPD	ENSMMUP00000075541	ENSMMUP00000003737	Lysophosphatidylcholine acyltransferase 1.	Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family.	0.474
NAPSA	CTSH	ENSMMUP00000074186	ENSMMUP00000013201	Napsin A aspartic peptidase; Belongs to the peptidase A1 family.	Cathepsin H; Belongs to the peptidase C1 family.	0.610
NAPSA	LOC719235	ENSMMUP00000074186	ENSMMUP00000023897	Napsin A aspartic peptidase; Belongs to the peptidase A1 family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.901
NAPSA	SFTPD	ENSMMUP00000074186	ENSMMUP00000003737	Napsin A aspartic peptidase; Belongs to the peptidase A1 family.	Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family.	0.679
SFTPD	LPCAT1	ENSMMUP00000003737	ENSMMUP00000075541	Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family.	Lysophosphatidylcholine acyltransferase 1.	0.474
SFTPD	NAPSA	ENSMMUP00000003737	ENSMMUP00000074186	Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family.	Napsin A aspartic peptidase; Belongs to the peptidase A1 family.	0.679
TGFB1	ITGB6	ENSMMUP00000031221	ENSMMUP00000053563	Transforming growth factor beta; Belongs to the TGF-beta family.	Integrin beta; Belongs to the integrin beta chain family.	0.906
TGFB1	KDR	ENSMMUP00000031221	ENSMMUP00000016642	Transforming growth factor beta; Belongs to the TGF-beta family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.424