(95 nodes) Response to amino acid network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BCL2	BCL2 apoptosis regulator. (241 aa)
	GLRA3	Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (464 aa)
	SESN3	Sestrin-3. (492 aa)
	CPS1	Carbamoyl-phosphate synthase 1. (1529 aa)
	SOCS1	Suppressor of cytokine signaling 1. (215 aa)
	CAPN2	Calpain-2 catalytic subunit isoform 1; Belongs to the peptidase C2 family. (700 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	UFL1	E3 UFM1-protein ligase 1. (793 aa)
	ATP7A	ATPase copper transporting alpha. (1500 aa)
	IPO5	Importin 5. (1097 aa)
	GCLM	Glutamate--cysteine ligase regulatory subunit. (274 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1717 aa)
	GLRA1	Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (449 aa)
	HSF1	Heat shock transcription factor 1. (507 aa)
	LAMTOR5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (169 aa)
	PNPLA3	Patatin like phospholipase domain containing 3. (481 aa)
	RRAGA	Ras-related GTP-binding protein A. (313 aa)
	MEAK7	MTOR associated protein, eak-7 homolog. (456 aa)
	LOC702037	Uncharacterized protein. (412 aa)
	SESN2	Sestrin-2. (480 aa)
	TOMM70	Mitochondrial import receptor subunit TOM70. (608 aa)
	PPP1R9B	Protein phosphatase 1 regulatory subunit 9B. (818 aa)
	COL5A2	Collagen type V alpha 2 chain. (1499 aa)
	NAT2	Arylamine N-acetyltransferase 2; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens (By similarity). (290 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	COL16A1	Collagen type XVI alpha 1 chain. (1604 aa)
	RRAGC	Ras related GTP binding C. (399 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (524 aa)
	ARG1	Arginase. (322 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
	GIP	Gastric inhibitory polypeptide. (153 aa)
	SLC7A5	Large neutral amino acids transporter small subunit 1. (507 aa)
	ENSMMUP00000078044	Uncharacterized protein. (84 aa)
	LAMTOR4	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (115 aa)
	GLRA2	Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
	FYN	Tyrosine-protein kinase. (589 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	GLRB	Glycine receptor subunit beta isoform A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
	SLC38A9	Putative sodium-coupled neutral amino acid transporter 9. (561 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1126 aa)
	HPCAL1	Hippocalcin like 1. (238 aa)
	ANAPC15	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (253 aa)
	SLC1A2	Amino acid transporter. (611 aa)
	AMIGO2	Adhesion molecule with Ig like domain 2. (521 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
	ENSMMUP00000041619	Uncharacterized protein. (319 aa)
	CASTOR2	GATS-like protein 2. (329 aa)
	CCN2	Cellular communication network factor 2. (349 aa)
	CPEB4	Cytoplasmic polyadenylation element-binding protein 4. (729 aa)
	COL3A1	Collagen alpha-1(III) chain preproprotein. (1466 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (908 aa)
	GCLC	Glutamate--cysteine ligase catalytic subunit isoform a. (637 aa)
	CEBPB	CCAAT/enhancer-binding protein. (344 aa)
	MMP2	72 kDa type IV collagenase isoform a preproprotein. (660 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (550 aa)
	LYN	Tyrosine-protein kinase. (577 aa)
	RRAGD	Ras-related GTP-binding protein D. (400 aa)
	HNF1A	HNF1 homeobox A. (657 aa)
	BAIAP2	Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 4. (534 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
	CPEB3	Cytoplasmic polyadenylation element binding protein 3. (768 aa)
	LAMTOR3	Ragulator complex protein LAMTOR3 isoform 1. (124 aa)
	COL1A2	Collagen type I alpha 2 chain. (1274 aa)
	AMIGO1	Amphoterin-induced protein 1. (493 aa)
	HPCA	Neuron-specific calcium-binding protein hippocalcin. (193 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B. (198 aa)
	SPAAR	Small regulatory polypeptide of amino acid response. (90 aa)
	BAD	Bcl2 antagonist of cell death. (167 aa)
	RRAGB	Ras-related GTP-binding protein B long isoform. (374 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1669 aa)
	NSMF	NMDA receptor synaptonuclear signaling and neuronal migration factor. (561 aa)
	SH3BP4	SH3 domain-binding protein 4. (963 aa)
	LAMTOR2	Robl_LC7 domain-containing protein. (135 aa)
	CYBA	Uncharacterized protein. (210 aa)
	NEURL1	Neuralized E3 ubiquitin protein ligase 1. (575 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
	NTRK2	Tyrosine-protein kinase receptor. (838 aa)
	GLRA4	Glycine receptor alpha 4; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
	GPRC6A	G protein-coupled receptor class C group 6 member A. (928 aa)
	ASS1	Argininosuccinate synthase. (412 aa)
	COL1A1	Collagen alpha-1(I) chain preproprotein. (1464 aa)
	COL6A1	Collagen alpha-1(VI) chain. (1028 aa)
	HNRNPAB	Heterogeneous nuclear ribonucleoprotein A/B isoform a. (332 aa)
	HNRNPD	Heterogeneous nuclear ribonucleoprotein D0 isoform a. (355 aa)
	CYBB	Cytochrome b-245 beta chain. (617 aa)
	BCL11A	BAF chromatin remodeling complex subunit BCL11A. (836 aa)
	AIFM1	Apoptosis-inducing factor 1, mitochondrial isoform 1. (613 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PDGFD	Platelet-derived growth factor D isoform 1. (370 aa)
	BCL2L1	Bcl-2-like protein 1 isoform 1. (233 aa)
	KCNB1	Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
	UBR1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1749 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1335 aa)
	COL4A6	Collagen type IV alpha 6 chain. (1705 aa)
	XBP1	X-box binding protein 1. (376 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	BCL2L1	ENSMMUP00000006568	ENSMMUP00000007865	Apoptosis-inducing factor 1, mitochondrial isoform 1.	Bcl-2-like protein 1 isoform 1.	0.410
AIFM1	COL4A6	ENSMMUP00000006568	ENSMMUP00000009457	Apoptosis-inducing factor 1, mitochondrial isoform 1.	Collagen type IV alpha 6 chain.	0.452
AIFM1	PIK3C3	ENSMMUP00000006568	ENSMMUP00000046296	Apoptosis-inducing factor 1, mitochondrial isoform 1.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.404
ANAPC15	CASTOR2	ENSMMUP00000036848	ENSMMUP00000043718	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	GATS-like protein 2.	0.525
ANAPC15	CDKN1B	ENSMMUP00000036848	ENSMMUP00000065552	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Cyclin-dependent kinase inhibitor 1B.	0.408
ANAPC15	ENSMMUP00000078044	ENSMMUP00000036848	ENSMMUP00000078044	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Uncharacterized protein.	0.970
ANAPC15	LAMTOR2	ENSMMUP00000036848	ENSMMUP00000071662	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Robl_LC7 domain-containing protein.	0.999
ANAPC15	LAMTOR3	ENSMMUP00000036848	ENSMMUP00000058258	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Ragulator complex protein LAMTOR3 isoform 1.	0.999
ANAPC15	LAMTOR4	ENSMMUP00000036848	ENSMMUP00000078248	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4.	0.998
ANAPC15	LAMTOR5	ENSMMUP00000036848	ENSMMUP00000019692	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5.	0.997
ANAPC15	MTOR	ENSMMUP00000036848	ENSMMUP00000073444	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.877
ANAPC15	PIK3CA	ENSMMUP00000036848	ENSMMUP00000006866	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.417
ANAPC15	RPS6KB1	ENSMMUP00000036848	ENSMMUP00000051640	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.463
ANAPC15	RPTOR	ENSMMUP00000036848	ENSMMUP00000008896	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Regulatory associated protein of MTOR complex 1.	0.983
ANAPC15	RRAGA	ENSMMUP00000036848	ENSMMUP00000024188	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Ras-related GTP-binding protein A.	0.998
ANAPC15	RRAGB	ENSMMUP00000036848	ENSMMUP00000068806	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Ras-related GTP-binding protein B long isoform.	0.996
ANAPC15	RRAGC	ENSMMUP00000036848	ENSMMUP00000031112	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Ras related GTP binding C.	0.998
ANAPC15	RRAGD	ENSMMUP00000036848	ENSMMUP00000052413	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Ras-related GTP-binding protein D.	0.996
ANAPC15	SESN2	ENSMMUP00000036848	ENSMMUP00000026289	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Sestrin-2.	0.527
ANAPC15	SESN3	ENSMMUP00000036848	ENSMMUP00000012297	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	Sestrin-3.	0.438