STRINGSTRING
KCNC3 KCNC3 SYNJ1 SYNJ1 GHRH GHRH KCNC2 KCNC2 GRIN1 GRIN1 SEPTIN6 SEPTIN6 LOC114672301 LOC114672301 UNC13C UNC13C AAK1 AAK1 PCSK1 PCSK1 NMU NMU UNC13B UNC13B TSPOAP1 TSPOAP1 SLC18A3 SLC18A3 EPHA4 EPHA4 GPER1 GPER1 CAD CAD DIXDC1 DIXDC1 SLC4A10 SLC4A10 ATP1A3 ATP1A3 SLC18A2 SLC18A2 CPLX4 CPLX4 SRSF10 SRSF10 UNC13A UNC13A SLC8A2 SLC8A2 ITGA2 ITGA2 BIN1 BIN1 P2RX4 P2RX4 GIT1 GIT1 FMR1 FMR1 UCN UCN CASR CASR PTPRN PTPRN SNCA SNCA PRKCB PRKCB P2RX3 P2RX3 TPRG1L TPRG1L AVPR1B AVPR1B CALCA CALCA KCNA1 KCNA1 PRNP PRNP SLC6A3 SLC6A3 TPBG TPBG SYP SYP SLC8A3 SLC8A3 UCN3 UCN3 NTRK2 NTRK2 TANC1 TANC1 CABP4 CABP4 OPHN1 OPHN1 CYFIP1 CYFIP1 FLRT3 FLRT3 KCNA6 KCNA6 SLC1A1 SLC1A1 HCN3 HCN3 SNCB SNCB TNN TNN SCGN SCGN SLC32A1 SLC32A1 TH TH ROR1 ROR1 TULP1 TULP1 KCNC1 KCNC1 SLC4A8 SLC4A8 PENK PENK PNOC PNOC PACSIN1 PACSIN1 CALB2 CALB2 PRRT2 PRRT2 PDYN PDYN OXT OXT SLC9A6 SLC9A6 CRHR2 CRHR2 CPLX3 CPLX3 GAD1 GAD1 PRSS12 PRSS12 SLC8A1 SLC8A1 AP3D1 AP3D1 LRRK2 LRRK2 NTSR1 NTSR1 KCNK2 KCNK2 GRIK5 GRIK5 SLC17A8 SLC17A8 CDH8 CDH8 KCNA2 KCNA2 ELK1 ELK1 SLC18A1 SLC18A1 CRHBP CRHBP NTS NTS MICAL1 MICAL1 PRKCG PRKCG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNC3Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (757 aa)
SYNJ1Synaptojanin 1. (1614 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2 isoform KV3.2b; Belongs to the potassium channel family. (638 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
SEPTIN6Septin 6; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (445 aa)
LOC114672301ETS domain-containing protein. (488 aa)
UNC13CUnc-13 homolog C. (2216 aa)
AAK1AP2 associated kinase 1. (1198 aa)
PCSK1Neuroendocrine convertase 1 isoform 1 preproprotein; Belongs to the peptidase S8 family. (749 aa)
NMUNeuromedin U. (173 aa)
UNC13BUnc-13 homolog B. (1971 aa)
TSPOAP1TSPO associated protein 1. (1936 aa)
SLC18A3Solute carrier family 18 member A3. (532 aa)
EPHA4EPH receptor A4. (1008 aa)
GPER1G-protein coupled estrogen receptor 1; G-protein coupled estrogen receptor that binds to 17-beta- estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine [...] (375 aa)
CADCarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2306 aa)
DIXDC1DIX domain containing 1. (683 aa)
SLC4A10Anion exchange protein. (1193 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1031 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
CPLX4Complexin IV. (160 aa)
SRSF10RRM domain-containing protein. (261 aa)
UNC13AUnc-13 homolog A. (1677 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
BIN1Bridging integrator 1. (668 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (467 aa)
GIT1GIT ArfGAP 1. (794 aa)
FMR1Fragile X mental retardation 1 protein isoform ISO1. (632 aa)
UCNUrocortin. (124 aa)
CASRCalcium sensing receptor. (1078 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (146 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (468 aa)
TPRG1LTumor protein p63-regulated gene 1-like protein. (272 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
KCNA1Voltage-gated potassium channel subunit Kv1.1; Belongs to the potassium channel family. (495 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (253 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (631 aa)
TPBGUncharacterized protein. (420 aa)
SYPSynaptophysin. (401 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
UCN3Urocortin 3. (210 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
TANC1Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1. (2023 aa)
CABP4Calcium binding protein 4. (303 aa)
OPHN1Oligophrenin-1. (802 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
FLRT3Fibronectin-like domain-containing leucine-rich transmembrane protein 3. (649 aa)
KCNA6BTB domain-containing protein; Belongs to the potassium channel family. (530 aa)
SLC1A1Excitatory amino acid transporter 3. (524 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (777 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (139 aa)
TNNTenascin N. (1299 aa)
SCGNSecretagogin, EF-hand calcium binding protein. (276 aa)
SLC32A1Vesicular inhibitory amino acid transporter. (525 aa)
THTyrosine hydroxylase. (501 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
TULP1Tubby-like protein; Belongs to the TUB family. (542 aa)
KCNC1BTB domain-containing protein; Belongs to the potassium channel family. (585 aa)
SLC4A8Anion exchange protein. (1093 aa)
PENKProenkephalin. (300 aa)
PNOCPrepronociceptin. (201 aa)
PACSIN1Protein kinase C and casein kinase substrate in neurons protein 1. (444 aa)
CALB2Uncharacterized protein. (272 aa)
PRRT2Proline-rich transmembrane protein 2 isoform 1. (340 aa)
PDYNProenkephalin-B preproprotein. (253 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (701 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (431 aa)
CPLX3Complexin III. (158 aa)
GAD1Glutamate decarboxylase 1 isoform GAD67. (594 aa)
PRSS12Neurotrypsin; Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations; Belongs to the peptidase S1 family. (875 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
AP3D1AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1215 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
NTSR1Neurotensin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (1388 aa)
SLC17A8Solute carrier family 17 member 8. (589 aa)
CDH8Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins. (743 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2 isoform a; Belongs to the potassium channel family. (499 aa)
ELK1ETS domain-containing protein Elk-1. (428 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
NTSNeurotensin/neuromedin N. (170 aa)
MICAL1Microtubule associated monooxygenase, calponin and LIM domain containing 1. (1069 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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