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RBKS RBKS PRKAG3 PRKAG3 PPP1R3D PPP1R3D GOT1 GOT1 PGM2 PGM2 PPP1R3C PPP1R3C LALBA LALBA MOGAT2 MOGAT2 SI SI GNMT GNMT GANC GANC NEU2 NEU2 MTMR7 MTMR7 IL6ST IL6ST PFKM PFKM NAGK NAGK HK3 HK3 NDST4 NDST4 INPP5E INPP5E LEPR LEPR HKDC1 HKDC1 HK1 HK1 GYS1 GYS1 ENOSF1 ENOSF1 GNE GNE PCDH12 PCDH12 ITPKA ITPKA PTEN PTEN EXT1 EXT1 OCRL OCRL MIOX MIOX GALK2 GALK2 MGAM MGAM PPP1CB PPP1CB PHKG2 PHKG2 PLA2G4A PLA2G4A AGL AGL PCK2 PCK2 GALK1 GALK1 PFKFB1 PFKFB1 AOAH AOAH FBP1 FBP1 PCK1 PCK1 PYGM PYGM PPP1R3A PPP1R3A NDST2 NDST2 SHPK SHPK B3GNT8 B3GNT8 ISYNA1 ISYNA1 IDH2 IDH2 SYNJ2 SYNJ2 SYNJ1 SYNJ1 B3GNT2 B3GNT2 TREH TREH DGAT2 DGAT2 INPP5J INPP5J PYGB PYGB HMGB1-2 HMGB1-2 IDNK IDNK FGGY FGGY PGD PGD PHKA2 PHKA2 INPP5B INPP5B HAS2 HAS2 BPNT1 BPNT1 BRAF BRAF EPM2AIP1 EPM2AIP1 TKFC TKFC PSORS1C2 PSORS1C2 PFKFB4 PFKFB4 G6PC G6PC ENSMMUP00000051017 ENSMMUP00000051017 GCK GCK GK GK INPP5K INPP5K PYGL PYGL PRKAG2 PRKAG2 MECP2 MECP2 XYLB XYLB IMPA1 IMPA1 UGP2 UGP2 GBE1 GBE1 GYG1 GYG1 B3GNT9 B3GNT9 CSGALNACT2 CSGALNACT2 GYG2 GYG2 LOC717098 LOC717098 PPIP5K1 PPIP5K1 AKT2 AKT2 PHKA1 PHKA1 ENSMMUP00000060372 ENSMMUP00000060372 GPD2 GPD2 GSK3B GSK3B PFKP PFKP GAL3ST3 GAL3ST3 AKT1 AKT1 IPPK IPPK PHKB PHKB B3GNT7 B3GNT7 HMGB1 HMGB1 PPP1R3G PPP1R3G PPIP5K2 PPIP5K2 EPM2A EPM2A NR1D1 NR1D1 FBP2 FBP2 TPI1 TPI1 ENSMMUP00000066575 ENSMMUP00000066575 GNPTG GNPTG CSGALNACT1 CSGALNACT1 B3GNT6 B3GNT6 PGP PGP PPP1R3B PPP1R3B STK40 STK40 COQ3 COQ3 ABHD10 ABHD10 GK2 GK2 B3GNT3 B3GNT3 LOC106992358 LOC106992358 B4GALT1 B4GALT1 PFKFB2 PFKFB2 ENSMMUP00000071571 ENSMMUP00000071571 ENSMMUP00000071729 ENSMMUP00000071729 GK5 GK5 IMPAD1 IMPAD1 HK2 HK2 FCSK FCSK B4GALT5 B4GALT5 INPP5A INPP5A MTMR2 MTMR2 IMPA2 IMPA2 INPP1 INPP1 GK3P GK3P PPP1CA PPP1CA SLC37A4 SLC37A4 NHLRC1 NHLRC1 GYS2 GYS2 IDH1 IDH1 MOGAT1 MOGAT1 PHKG1 PHKG1 NDST3 NDST3 PPP1R3E PPP1R3E PER2 PER2 HS2ST1 HS2ST1 PPP1CC PPP1CC COQ2 COQ2 HAS1 HAS1 B3GNT4 B3GNT4 GNPTAB GNPTAB LCT LCT MOGAT3 MOGAT3 HAS3 HAS3 PFKFB3 PFKFB3 RPE RPE RB1CC1 RB1CC1 ITPK1 ITPK1 ENSMMUP00000080356 ENSMMUP00000080356 ACCS ACCS ANGPTL3 ANGPTL3 PPP1R1A PPP1R1A PFKL PFKL IDUA IDUA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RBKSRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (322 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
GOT1Aspartate aminotransferase. (413 aa)
PGM2Phosphoglucomutase 2. (612 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
LALBALactose synthase B protein; Belongs to the glycosyl hydrolase 22 family. (142 aa)
MOGAT2Monoacylglycerol O-acyltransferase 2. (334 aa)
SISucrase-isomaltase. (1823 aa)
GNMTGlycine N-methyltransferase. (295 aa)
GANCGal_mutarotas_2 domain-containing protein; Belongs to the glycosyl hydrolase 31 family. (915 aa)
NEU2Neuraminidase 2. (381 aa)
MTMR7Myotubularin-related protein 7. (660 aa)
IL6STUncharacterized protein. (942 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
NAGKN-acetylglucosamine kinase. (344 aa)
HK3Hexokinase 3. (923 aa)
NDST4N-deacetylase and N-sulfotransferase 4. (872 aa)
INPP5E72 kDa inositol polyphosphate 5-phosphatase. (644 aa)
LEPRLeptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1163 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK1Hexokinase 1. (921 aa)
GYS1Glycogen [starch] synthase, muscle; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan; Belongs to the glycosyltransferase 3 family. (737 aa)
ENOSF1Mitochondrial enolase superfamily member 1 isoform rTSbeta. (443 aa)
GNEUDP-GlcNAc-2-epimerase/ManAc kinase. (753 aa)
PCDH12Protocadherin 12. (1184 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (461 aa)
PTENUncharacterized protein. (589 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
OCRLInositol polyphosphate 5-phosphatase OCRL-1 isoform b. (893 aa)
MIOXMyo-inositol oxygenase. (285 aa)
GALK2Galactokinase 2. (447 aa)
MGAMMaltase-glucoamylase. (1849 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa)
PHKG2Phosphorylase b kinase gamma catalytic chain, testis/liver isoform isoform 1; Belongs to the protein kinase superfamily. (406 aa)
PLA2G4APhospholipase A2. (749 aa)
AGLAmylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase. (1532 aa)
PCK2Uncharacterized protein. (644 aa)
GALK1Galactokinase 1. (529 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (522 aa)
AOAHAcyloxyacyl hydrolase. (687 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (467 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1145 aa)
NDST2Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2. (883 aa)
SHPKFGGY_N domain-containing protein. (478 aa)
B3GNT8Hexosyltransferase. (397 aa)
ISYNA1Inositol-3-phosphate synthase 1. (722 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
SYNJ2Synaptojanin 2. (1501 aa)
SYNJ1Synaptojanin 1. (1614 aa)
B3GNT2Hexosyltransferase. (397 aa)
TREHTrehalase. (583 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (434 aa)
INPP5JInositol polyphosphate-5-phosphatase J. (1001 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (1186 aa)
HMGB1-2High mobility group protein B1. (214 aa)
IDNKGluconokinase; Belongs to the gluconokinase GntK/GntV family. (311 aa)
FGGYFGGY carbohydrate kinase domain containing. (551 aa)
PGD6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
INPP5BType II inositol-1,4,5-trisphosphate 5-phosphatase. (913 aa)
HAS2Hyaluronan synthase 2. (552 aa)
BPNT13'(2'),5'-bisphosphate nucleotidase 1. (308 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
EPM2AIP1EPM2A interacting protein 1. (602 aa)
TKFCTriokinase and FMN cyclase. (598 aa)
PSORS1C2Uncharacterized protein. (136 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4. (469 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
ENSMMUP00000051017Uncharacterized protein. (59 aa)
GCKPhosphotransferase. (466 aa)
GKGlycerol kinase isoform d; Belongs to the FGGY kinase family. (559 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform 1. (448 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
XYLBXylulokinase. (588 aa)
IMPA1Inositol-1-monophosphatase. (329 aa)
UGP2UTP--glucose-1-phosphate uridylyltransferase. (508 aa)
GBE11,4-alpha-glucan branching enzyme 1. (704 aa)
GYG1Glycogenin-1 isoform 1. (350 aa)
B3GNT9Hexosyltransferase. (401 aa)
CSGALNACT2Hexosyltransferase. (542 aa)
GYG2Glycogenin 2. (609 aa)
LOC717098Uncharacterized protein; Belongs to the histidine acid phosphatase family. (217 aa)
PPIP5K1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1437 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1223 aa)
ENSMMUP00000060372Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (280 aa)
GPD2Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (727 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (797 aa)
GAL3ST3Galactose-3-O-sulfotransferase 3. (431 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IPPKInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (536 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1093 aa)
B3GNT7Hexosyltransferase. (401 aa)
HMGB1High mobility group box 1. (215 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (353 aa)
PPIP5K2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1278 aa)
EPM2AEPM2A glucan phosphatase, laforin. (331 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
FBP2FBPase domain-containing protein; Belongs to the FBPase class 1 family. (345 aa)
TPI1Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (286 aa)
ENSMMUP00000066575Uncharacterized protein. (142 aa)
GNPTGN-acetylglucosamine-1-phosphate transferase subunit gamma. (345 aa)
CSGALNACT1Hexosyltransferase. (532 aa)
B3GNT6Hexosyltransferase. (384 aa)
PGPPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (322 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
STK40Serine/threonine-protein kinase 40. (435 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (368 aa)
ABHD10Abhydrolase domain containing 10. (306 aa)
GK2Glycerol kinase 2; Belongs to the FGGY kinase family. (553 aa)
B3GNT3Hexosyltransferase. (373 aa)
LOC106992358Uncharacterized protein. (187 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2 isoform a. (505 aa)
ENSMMUP00000071571Uncharacterized protein. (239 aa)
ENSMMUP00000071729FBPase domain-containing protein; Belongs to the FBPase class 1 family. (498 aa)
GK5Putative glycerol kinase 5; Belongs to the FGGY kinase family. (529 aa)
IMPAD1Inositol monophosphatase domain containing 1. (384 aa)
HK2Hexokinase 2. (917 aa)
FCSKFucose kinase. (1084 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (582 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (450 aa)
MTMR2Myotubularin-related protein 2 isoform 1. (643 aa)
IMPA2Inositol-1-monophosphatase. (288 aa)
INPP1Inositol polyphosphate-1-phosphatase. (522 aa)
GK3PUncharacterized protein; Belongs to the FGGY kinase family. (558 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (347 aa)
SLC37A4Glucose-6-phosphate translocase isoform 2. (451 aa)
NHLRC1NHL repeat containing E3 ubiquitin protein ligase 1. (395 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
MOGAT1Monoacylglycerol O-acyltransferase 1. (427 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (418 aa)
NDST3Uncharacterized protein. (873 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
PER2Period circadian regulator 2. (1254 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1 isoform 1. (356 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
COQ24-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (400 aa)
HAS1Hyaluronan synthase 1. (673 aa)
B3GNT4Hexosyltransferase. (353 aa)
GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (1256 aa)
LCTLactase. (1928 aa)
MOGAT3Monoacylglycerol O-acyltransferase 3. (437 aa)
HAS3Uncharacterized protein. (484 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (562 aa)
RPERibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform 1. (1594 aa)
ITPK1Inositol-tetrakisphosphate 1-kinase. (611 aa)
ENSMMUP00000080356FBPase domain-containing protein; Belongs to the FBPase class 1 family. (206 aa)
ACCSExostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (857 aa)
ANGPTL3Angiopoietin like 3. (476 aa)
PPP1R1AUncharacterized protein. (175 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (1016 aa)
IDUAIduronidase alpha-L-. (653 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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