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| | KLRC2 | NKG2-C type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (415 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | OPRD1 | YTH N6-methyladenosine RNA binding protein 2. (589 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa) |
| | TKFC | Triokinase and FMN cyclase. (598 aa) |
| | TREX1 | Three prime repair exonuclease 1. (474 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1044 aa) |
| | IRF1 | Interferon regulatory factor. (325 aa) |
| | ERAP1 | Aminopeptidase. (941 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3. (790 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1102 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | NONO | Uncharacterized protein. (504 aa) |
| | FAM3A | Family with sequence similarity 3 member A. (244 aa) |
| | KLRK1 | NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] (216 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa) |
| | HMGB1-2 | High mobility group protein B1. (214 aa) |
| | METTL3 | N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (580 aa) |
| | DHX58 | DExH-box helicase 58. (678 aa) |
| | FCN2 | Fibrinogen C-terminal domain-containing protein. (365 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa) |
| | NECTIN2 | Poliovirus receptor-related protein 2 isoform delta. (538 aa) |
| | TLR8 | Toll-like receptor 8; Belongs to the Toll-like receptor family. (1040 aa) |
| | TYRO3 | Tyrosine-protein kinase receptor TYRO3. (890 aa) |
| | CLEC6A | C-type lectin domain containing 6A. (209 aa) |
| | CR1 | Complement C3b/C4b receptor 1 (Knops blood group). (2041 aa) |
| | MASP1 | Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (753 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (488 aa) |
| | CXHXorf21 | Uncharacterized protein. (301 aa) |
| | SERPING1 | Serpin family G member 1; Belongs to the serpin family. (627 aa) |
| | NLRX1 | NLR family member X1. (972 aa) |
| | STING1 | Stimulator of interferon protein. (379 aa) |
| | PAK2 | Non-specific serine/threonine protein kinase. (524 aa) |
| | SLAMF8 | SLAM family member 8. (285 aa) |
| | UBE2K | Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (217 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (215 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (626 aa) |
| | POLR3B | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa) |
| | PYHIN1 | Pyrin and HIN domain family member 1. (523 aa) |
| | SLAMF6 | SLAM family member 6. (339 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (716 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (538 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (453 aa) |
| | PSPC1 | Paraspeckle component 1. (523 aa) |
| | MATR3 | Uncharacterized protein. (895 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (291 aa) |
| | COCH | Cochlin. (550 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa) |
| | CACTIN | Chromosome 19 open reading frame 29. (760 aa) |
| | GRN | Granulin precursor. (593 aa) |
| | NR1H2 | Nuclear receptor subfamily 1 group H member 2. (461 aa) |
| | DCST1 | DC-STAMP domain containing 1. (706 aa) |
| | POLR3D | DNA-directed RNA polymerase III subunit RPC4. (397 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | ADAM8 | ADAM metallopeptidase domain 8. (823 aa) |
| | LILRA1 | Uncharacterized protein. (518 aa) |
| | IRF3 | Interferon regulatory factor 3. (450 aa) |
| | ZBP1 | Z-DNA binding protein 1. (420 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | SRC | Tyrosine-protein kinase. (644 aa) |
| | TOMM70 | Mitochondrial import receptor subunit TOM70. (608 aa) |
| | H9H440_MACMU | MHC_I-like_Ag-recog domain-containing protein. (128 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. (317 aa) |
| | CGAS | Cyclic GMP-AMP synthase. (573 aa) |
| | SFPQ | Splicing factor, proline-and glutamine-rich. (707 aa) |
| | N4BP1 | NEDD4 binding protein 1. (896 aa) |
| | POLR3G | DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (223 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (575 aa) |
| | LAMP1 | Lysosomal associated membrane protein 1. (733 aa) |
| | LAG3 | Lymphocyte activating 3. (533 aa) |
| | ENSMMUP00000073450 | Ig-like domain-containing protein; Belongs to the MHC class I family. (369 aa) |
| | PYCARD | Apoptosis-associated speck-like protein containing a CARD isoform a. (195 aa) |
| | PARP14 | Poly [ADP-ribose] polymerase. (1827 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | TRAFD1 | TRAF-type zinc finger domain-containing protein 1. (582 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) |
| | NCR1 | Natural cytotoxicity triggering receptor 1. (306 aa) |
| | TIRAP | Toll/interleukin-1 receptor domain-containing adapter protein isoform a. (220 aa) |
| | FCN3 | Ficolin 3. (320 aa) |
| | MUL1 | Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa) |
| | APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (664 aa) |
| | HEXIM1 | Protein HEXIM1. (359 aa) |
| | ZNFX1 | NFX1-type zinc finger-containing protein 1. (1918 aa) |
| | YTHDF3 | YTH N6-methyladenosine RNA binding protein 3. (588 aa) |
| | ENSMMUP00000068968 | CDC37_N domain-containing protein. (225 aa) |
| | POLR3C | RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (538 aa) |
| | PVR | Uncharacterized protein. (417 aa) |
| | LYAR | Cell growth-regulating nucleolar protein. (379 aa) |
| | CDC37 | Cell division cycle 37. (403 aa) |
| | LBP | Lipopolysaccharide binding protein. (508 aa) |
| | EREG | Proepiregulin. (169 aa) |
| | HSP90AA1 | HATPase_c domain-containing protein. (733 aa) |
| | FYN | Tyrosine-protein kinase. (589 aa) |
| | NLRC5 | NLR family CARD domain containing 5. (1866 aa) |
| | SERPINB9 | Serpin family B member 9; Belongs to the serpin family. (515 aa) |
| | GFER | Sulfhydryl oxidase. (205 aa) |
| | ISG15 | Ubiquitin-like protein ISG15. (165 aa) |
| | XRCC6 | X-ray repair cross-complementing protein 6. (609 aa) |
| | NFE2L2 | Nuclear factor erythroid 2-related factor 2 isoform 1. (606 aa) |
| | FCN1 | Ficolin 1. (326 aa) |
| | USP15 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa) |
| | EP300 | Histone acetyltransferase p300. (2414 aa) |
| | TRIM21 | E3 ubiquitin-protein ligase TRIM21. (475 aa) |
| | VSIG4 | V-set and immunoglobulin domain containing 4. (404 aa) |
| | IGF2 | Insulin like growth factor 2. (244 aa) |
| | ARG1 | Arginase. (322 aa) |
| | TYROBP | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (241 aa) |
| | BIRC2 | Baculoviral IAP repeat-containing protein 2. (618 aa) |
| | NLRC3 | NLR family CARD domain containing 3. (1117 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (626 aa) |
| | CRTAM | Cytotoxic and regulatory T cell molecule. (401 aa) |
| | LOC721374 | Uncharacterized protein. (117 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa) |
| | FGR | Tyrosine-protein kinase. (529 aa) |
| | LOC714190 | Uncharacterized protein. (442 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (415 aa) |
| | LOC106995258 | Uncharacterized protein. (301 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1273 aa) |
| | NCR3 | Natural cytotoxicity triggering receptor 3; Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation. (220 aa) |
| | MAMU-F | Mamu class I histocompatibility antigen, alpha chain F; Involved in the presentation of foreign antigens to the immune system. (348 aa) |
| | C3 | Uncharacterized protein. (1663 aa) |
| | SH2D1B | SH2 domain containing 1B. (132 aa) |
| | CASP6 | Caspase 6; Belongs to the peptidase C14A family. (293 aa) |
| | DNAJA3 | DnaJ heat shock protein family (Hsp40) member A3. (480 aa) |
| | RNF135 | Ring finger protein 135. (435 aa) |
| | PTPN1 | Tyrosine-protein phosphatase non-receptor type. (435 aa) |
| | RBM14 | RNA-binding protein 14 isoform 1. (669 aa) |
| | HPX | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (460 aa) |
| | ADAR | Adenosine deaminase RNA specific. (1268 aa) |
| | CREBBP | CREB-binding protein isoform a. (2442 aa) |
| | CD226 | CD226 antigen; Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T- lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding. (358 aa) |
| | LOC714514 | Uncharacterized protein. (1786 aa) |
| | CD96 | CD96 molecule. (569 aa) |
| | TBK1 | Serine/threonine-protein kinase TBK1. (729 aa) |
| | LRP8 | LDL receptor related protein 8. (959 aa) |
| | SH2D1A | SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Ca [...] (130 aa) |
| | NCF1 | Neutrophil cytosolic factor 1. (390 aa) |
| | MASP2 | Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa) |
| | FPR2 | N-formyl peptide receptor 2; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (By similarity). Binding of FMLP to the receptor causes activation of neutrophils (By similarity). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5- stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity). (369 aa) |
| | SLC15A4 | Solute carrier family 15 member 4. (577 aa) |
| | H9H333_MACMU | MHC_I-like_Ag-recog domain-containing protein. (308 aa) |
| | HAVCR2 | Hepatitis A virus cellular receptor 2. (294 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa) |
| | PQBP1 | Polyglutamine binding protein 1. (286 aa) |
| | MNDA | Gamma-interferon-inducible protein 16 isoform 2. (729 aa) |
| | DUSP10 | Dual specificity protein phosphatase 10 isoform a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa) |
| | MMP12 | Matrix metallopeptidase 12. (470 aa) |
| | POLR3F | DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (314 aa) |
| | STAT5B | Signal transducer and activator of transcription. (787 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (535 aa) |
| | CLEC12B | C-type lectin domain family 12 member B isoform 1. (276 aa) |
| | AKIRIN2 | Akirin 2. (427 aa) |
| | OTOP1 | Otopetrin 1. (610 aa) |
| | FFAR2 | G-protein coupled receptor 43; Belongs to the G-protein coupled receptor 1 family. (330 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | KIR3DL3 | Uncharacterized protein. (475 aa) |
| | GIMAP5 | AIG1-type G domain-containing protein. (338 aa) |
| | STAT2 | Signal transducer and activator of transcription. (851 aa) |
| | F6YRS3_MACMU | Ku domain-containing protein. (326 aa) |
| | COLEC10 | Collectin subfamily member 10. (277 aa) |
| | PLA2G5 | Phospholipase A(2). (152 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | MAVS | Mitochondrial antiviral-signaling protein isoform 1. (541 aa) |
| | TRIM56 | E3 ubiquitin-protein ligase TRIM56. (755 aa) |
| | CLNK | Cytokine dependent hematopoietic cell linker. (443 aa) |
| | NMI | N-myc and STAT interactor. (307 aa) |
| | KLRD1 | Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (179 aa) |
| | RASGRP1 | RAS guanyl releasing protein 1. (826 aa) |
| | AIM2 | Absent in melanoma 2. (343 aa) |
| | IL21 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | HMGB1 | High mobility group box 1. (215 aa) |
| | TRIM41 | Tripartite motif containing 41. (726 aa) |
| | ACOD1 | Aconitate decarboxylase 1. (481 aa) |
| | TTLL12 | Tubulin tyrosine ligase like 12. (662 aa) |
| | USP27X | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (438 aa) |
| | ENSMMUP00000062785 | Uncharacterized protein. (300 aa) |
| | CEACAM1 | Uncharacterized protein. (525 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (596 aa) |
| | IFNK | Interferon kappa. (207 aa) |
| | TRIM62 | Tripartite motif containing 62. (741 aa) |
| | APPL1 | Uncharacterized protein. (846 aa) |
| | CADM1 | Cell adhesion molecule 1. (474 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (928 aa) |
| | CD160 | CD160 molecule. (229 aa) |
| | ENSMMUP00000057803 | MHC_I-like_Ag-recog domain-containing protein. (216 aa) |
| | LOC715778 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (233 aa) |
| | ZCCHC3 | Zinc finger CCHC-type containing 3. (402 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (818 aa) |
| | IFI35 | Interferon induced protein 35. (338 aa) |
| | LSM14A | Uncharacterized protein. (487 aa) |
| | CNOT7 | Uncharacterized protein. (401 aa) |
| | RIOK3 | Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa) |
| | KLRB1 | Killer cell lectin like receptor B1. (227 aa) |
| | MBL2 | Mannose binding lectin 2. (255 aa) |
| | PTPN22 | Protein tyrosine phosphatase non-receptor type 22. (813 aa) |
| | LYN | Tyrosine-protein kinase. (577 aa) |
| | TRIM5 | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (496 aa) |
