(35 nodes) Myoblast differentiation network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BCL9L	BCL9 like. (1500 aa)
	PLEC	Plectin. (4862 aa)
	TCF7L2	Transcription factor 7 like 2. (632 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	REST	RE1 silencing transcription factor. (1095 aa)
	BCL9	B-cell CLL/lymphoma 9 protein. (1426 aa)
	MBNL1	Muscleblind like splicing regulator 1. (399 aa)
	MYOCD	Myocardin. (986 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	DDX17	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (731 aa)
	IGF1	Insulin like growth factor 1. (208 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	LOC106995726	Uncharacterized protein. (144 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (1014 aa)
	SDC1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (505 aa)
	ISL1	ISL LIM homeobox 1. (413 aa)
	NRG1	Neuregulin 1. (700 aa)
	IFRD1	Interferon-related developmental regulator 1 isoform 1. (451 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	PITX1	Homeobox protein. (348 aa)
	HINFP	Histone H4 transcription factor isoform 1. (517 aa)
	SOX15	SRY-box transcription factor 15. (233 aa)
	TBXT	T-box transcription factor T. (430 aa)
	PLEKHM3	Pleckstrin homology domain-containing family M member 3. (761 aa)
	SRF	Serum response factor. (508 aa)
	MAPK12	Mitogen-activated protein kinase. (479 aa)
	RB1	Retinoblastoma-associated protein. (928 aa)
	MEGF10	Multiple EGF like domains 10. (1137 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	EPAS1	Endothelial PAS domain protein 1. (875 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL9	BCL9L	ENSMMUP00000022067	ENSMMUP00000055504	B-cell CLL/lymphoma 9 protein.	BCL9 like.	0.698
BCL9	TCF7L2	ENSMMUP00000022067	ENSMMUP00000030026	B-cell CLL/lymphoma 9 protein.	Transcription factor 7 like 2.	0.898
BCL9L	BCL9	ENSMMUP00000055504	ENSMMUP00000022067	BCL9 like.	B-cell CLL/lymphoma 9 protein.	0.698
BCL9L	TCF7L2	ENSMMUP00000055504	ENSMMUP00000030026	BCL9 like.	Transcription factor 7 like 2.	0.703
DDX17	DDX5	ENSMMUP00000005760	ENSMMUP00000012376	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.907
DDX17	MYOD1	ENSMMUP00000005760	ENSMMUP00000008443	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.527
DDX5	DDX17	ENSMMUP00000012376	ENSMMUP00000005760	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.907
DDX5	MYOD1	ENSMMUP00000012376	ENSMMUP00000008443	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.451
EPAS1	NOTCH1	ENSMMUP00000054188	ENSMMUP00000022401	Endothelial PAS domain protein 1.	Notch receptor 1.	0.589
FGF6	IGF1	ENSMMUP00000068686	ENSMMUP00000002988	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Insulin like growth factor 1.	0.702
FGF6	NOTCH1	ENSMMUP00000068686	ENSMMUP00000022401	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Notch receptor 1.	0.433
FGF6	SDC1	ENSMMUP00000068686	ENSMMUP00000063420	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.534
FGF6	SHH	ENSMMUP00000068686	ENSMMUP00000065431	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.655
IGF1	FGF6	ENSMMUP00000002988	ENSMMUP00000068686	Insulin like growth factor 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.702
IGF1	MYOD1	ENSMMUP00000002988	ENSMMUP00000008443	Insulin like growth factor 1.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.506
IGF1	SHH	ENSMMUP00000002988	ENSMMUP00000065431	Insulin like growth factor 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.460
ISL1	SHH	ENSMMUP00000063915	ENSMMUP00000065431	ISL LIM homeobox 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.503
ISL1	TBX2	ENSMMUP00000063915	ENSMMUP00000052437	ISL LIM homeobox 1.	T-box transcription factor 2.	0.481
ITGB1	PLEC	ENSMMUP00000023374	ENSMMUP00000031861	Integrin beta; Belongs to the integrin beta chain family.	Plectin.	0.497
ITGB1	SDC1	ENSMMUP00000023374	ENSMMUP00000063420	Integrin beta; Belongs to the integrin beta chain family.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.543