STRINGSTRING
CLDN3 CLDN3 PRKCE PRKCE DRD2 DRD2 FYN FYN GLRA2 GLRA2 TBXA2R TBXA2R S100A8 S100A8 RPS6KB1 RPS6KB1 SREBF1 SREBF1 PSMD14 PSMD14 SLC23A2 SLC23A2 TP53INP1 TP53INP1 ADCY7 ADCY7 BIRC2 BIRC2 NPPC NPPC CYBB CYBB KCNMB1 KCNMB1 AVP AVP ABAT ABAT ARSA ARSA MAOB MAOB BAD BAD BAK1 BAK1 SOD1 SOD1 ENSMMUP00000065445 ENSMMUP00000065445 LOC114675515 LOC114675515 ABCB11 ABCB11 RARA RARA UNC79 UNC79 IGF1R IGF1R MGMT MGMT EIF4G1 EIF4G1 RGS7 RGS7 CD14 CD14 NR0B2 NR0B2 RGS19 RGS19 RGS2 RGS2 CLDN7 CLDN7 CBL CBL HDAC2 HDAC2 CRHR1 CRHR1 ADIPOQ ADIPOQ PTK2B PTK2B GRIN2B GRIN2B TJP1 TJP1 G6PD G6PD SPINK1 SPINK1 DBH DBH CLDN5 CLDN5 GRIN3A GRIN3A PPARA PPARA GRIN1 GRIN1 ITPR2 ITPR2 OGG1 OGG1 KCNC2 KCNC2 CASP8 CASP8 SLC2A4 SLC2A4 DMAP1 DMAP1 GABBR1 GABBR1 GNRH1 GNRH1 HMGCS2 HMGCS2 VCAM1 VCAM1 SLC10A1 SLC10A1 CRHBP CRHBP POLB POLB ST6GAL1 ST6GAL1 CHRNB2 CHRNB2 EHMT2 EHMT2 EPS8 EPS8 OPRM1 OPRM1 GRIN2A GRIN2A FGFR2 FGFR2 FGF19 FGF19 ADCYAP1R1 ADCYAP1R1 GOT2 GOT2 CYP7A1 CYP7A1 PENK PENK GATA3 GATA3 TYMS TYMS TH TH TUFM TUFM CSF3 CSF3 DRD4 DRD4 CLDN1 CLDN1 TACR1 TACR1 CPT1A CPT1A CA3 CA3 GLRA1 GLRA1 CLDN18 CLDN18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
FYNTyrosine-protein kinase. (589 aa)
GLRA2Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
TBXA2RThromboxane A2 receptor. (343 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (550 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
SLC23A2Sodium-dependent vitamin C transporter 2. (650 aa)
TP53INP1Tumor protein p53-inducible nuclear protein 1 isoform a. (241 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (618 aa)
NPPCC-type natriuretic peptide. (126 aa)
CYBBCytochrome b-245 beta chain. (617 aa)
KCNMB1Calcium-activated potassium channel subunit beta-1. (191 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
ABAT4-aminobutyrate aminotransferase. (568 aa)
ARSAArylsulfatase A. (507 aa)
MAOBAmine oxidase. (520 aa)
BADBcl2 antagonist of cell death. (167 aa)
BAK1Uncharacterized protein. (261 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (161 aa)
ENSMMUP00000065445Uncharacterized protein. (230 aa)
LOC114675515Uncharacterized protein. (152 aa)
ABCB11ATP binding cassette subfamily B member 11. (1323 aa)
RARARetinoic acid receptor alpha isoform 1. (462 aa)
UNC79Unc-79 homolog, NALCN channel complex subunit. (2458 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
MGMTMethylated-DNA--protein-cysteine methyltransferase. (238 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1 isoform 6. (1604 aa)
RGS7Regulator of G protein signaling 7. (487 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
RGS19Regulator of G-protein signaling 19. (217 aa)
RGS2Regulator of G-protein signaling 2. (211 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CBLE3 ubiquitin-protein ligase CBL. (907 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
CRHR1Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...] (444 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1860 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (512 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
DBHDopamine beta-hydroxylase. (620 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
OGG1ENDO3c domain-containing protein. (395 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2 isoform KV3.2b; Belongs to the potassium channel family. (638 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (612 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (962 aa)
GNRH1GnRH-associated peptide 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. (96 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
SLC10A1Solute carrier family 10 member a1. (349 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (370 aa)
ST6GAL1Beta-galactoside alpha-2,6-sialyltransferase 1 isoform a; Belongs to the glycosyltransferase 29 family. (406 aa)
CHRNB2Neuronal acetylcholine receptor subunit beta-2. (502 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1266 aa)
EPS8SH3 domain-containing protein. (833 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (400 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (538 aa)
GOT2Aspartate aminotransferase. (430 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
PENKProenkephalin. (300 aa)
GATA3GATA binding protein 3. (444 aa)
TYMSThymidylate synthetase. (313 aa)
THTyrosine hydroxylase. (501 aa)
TUFMElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (488 aa)
CSF3Colony stimulating factor 3. (207 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (418 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (809 aa)
CA3Carbonic anhydrase 3; Belongs to the alpha-carbonic anhydrase family. (295 aa)
GLRA1Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (449 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (12%) [HD]