STRINGSTRING
PPP3CA PPP3CA FAXDC2 FAXDC2 RAB7B RAB7B KITLG KITLG ISG15 ISG15 NCKAP1L NCKAP1L INHBA INHBA ZNF16 ZNF16 SMAP1 SMAP1 RUNX1 RUNX1 PF4 PF4 FAM210B FAM210B CCR1 CCR1 FOS FOS MPL MPL PRMT1 PRMT1 CSF3 CSF3 CSF1 CSF1 RHEX RHEX SCIN SCIN IL23R IL23R BRD1 BRD1 ARNT ARNT PLA2G3 PLA2G3 ACVR2A ACVR2A HOXA5 HOXA5 PRKCA PRKCA POU4F2 POU4F2 CD4 CD4 TAL1 TAL1 IL34 IL34 IFNG IFNG HMGB1 HMGB1 CALCA CALCA MED1 MED1 ENSMMUP00000062204 ENSMMUP00000062204 FADD FADD GPR68 GPR68 MAPK14 MAPK14 IL20 IL20 ENSMMUP00000057513 ENSMMUP00000057513 STAT1 STAT1 TNF TNF IL17A IL17A PPARGC1B PPARGC1B STAT5B STAT5B JAG1 JAG1 TRAF6 TRAF6 KLF10 KLF10 SLC9B2 SLC9B2 PITHD1 PITHD1 ETS1 ETS1 TRIB1 TRIB1 ABCB10 ABCB10 TGFB1 TGFB1 TREM2 TREM2 POU4F1 POU4F1 CREB1 CREB1 CASP8 CASP8 HMGB1-2 HMGB1-2 ROR2 ROR2 GATA2 GATA2 IL23A IL23A NEDD9 NEDD9 STAT3 STAT3 LEF1 LEF1 NOTCH2 NOTCH2 ZFP36L1 ZFP36L1 RB1 RB1 TMEM64 TMEM64 FES FES KAT7 KAT7 LIF LIF ACVR1B ACVR1B ACIN1 ACIN1 RCOR1 RCOR1 MTURN MTURN HIF1A HIF1A THPO THPO INPP5D INPP5D CD74 CD74 EVI2B EVI2B RIPK1 RIPK1 TNFSF11 TNFSF11 TESC TESC CD101 CD101 GATA1 GATA1 PRKDC PRKDC ANKRD54 ANKRD54 HSF1 HSF1 NINJ1 NINJ1 HCLS1 HCLS1 HAX1 HAX1 DCSTAMP DCSTAMP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP3CASerine/threonine-protein phosphatase. (547 aa)
FAXDC2Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (349 aa)
RAB7BRas-related protein Rab-7b. (199 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (283 aa)
ISG15Ubiquitin-like protein ISG15. (165 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
INHBAInhibin subunit beta A. (426 aa)
ZNF16Zinc finger protein 16. (682 aa)
SMAP1Arf-GAP domain-containing protein. (543 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
PF4C-X-C motif chemokine. (101 aa)
FAM210BFamily with sequence similarity 210 member B. (192 aa)
CCR1C-C chemokine receptor type 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. (355 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (635 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
CSF3Colony stimulating factor 3. (207 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
RHEXRegulator of hemoglobinization and erythroid cell expansion. (178 aa)
SCINScinderin. (715 aa)
IL23RInterleukin 23 receptor. (629 aa)
BRD1Bromodomain containing 1. (1189 aa)
ARNTUncharacterized protein. (786 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
HOXA5Homeobox A5. (381 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
POU4F2POU domain protein. (408 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
TAL1BHLH domain-containing protein. (331 aa)
IL34Uncharacterized protein. (364 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
HMGB1High mobility group box 1. (215 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
ENSMMUP00000062204Uncharacterized protein. (81 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (365 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IL20Interleukin 20. (176 aa)
ENSMMUP00000057513Uncharacterized protein. (260 aa)
STAT1Signal transducer and activator of transcription. (802 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL17AInterleukin 17A. (155 aa)
PPARGC1BPPARG coactivator 1 beta. (1023 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
KLF10Transforming growth factor-beta-inducible early growth response protein 1. (480 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
PITHD1PITH domain-containing protein 1. (211 aa)
ETS1ETS proto-oncogene 1, transcription factor. (548 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
ABCB10ATP binding cassette subfamily B member 10. (738 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (291 aa)
POU4F1POU domain protein. (423 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
HMGB1-2High mobility group protein B1. (214 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
GATA2GATA binding protein 2. (480 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
STAT3Signal transducer and activator of transcription. (871 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
ZFP36L1ZFP36 ring finger protein like 1. (344 aa)
RB1Retinoblastoma-associated protein. (928 aa)
TMEM64Transmembrane protein 64. (389 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
LIFLIF interleukin 6 family cytokine. (206 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
ACIN1Apoptotic chromatin condensation inducer 1. (1340 aa)
RCOR1REST corepressor 1. (505 aa)
MTURNMaturin, neural progenitor differentiation regulator homolog. (294 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
THPOThrombopoietin. (353 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1208 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform a. (294 aa)
EVI2BEcotropic viral integration site 2B. (451 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
TESCTescalcin isoform 1. (214 aa)
CD101CD101 molecule. (1021 aa)
GATA1GATA binding protein 1. (413 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
ANKRD54Ankyrin repeat domain-containing protein 54. (299 aa)
HSF1Heat shock transcription factor 1. (507 aa)
NINJ1Ninjurin-1. (152 aa)
HCLS1SH3 domain-containing protein. (551 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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