node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD2 | CSRP3 | ENSMMUP00000026346 | ENSMMUP00000067509 | Ankyrin repeat domain 2. | Cysteine and glycine rich protein 3. | 0.414 |
BMP4 | NOTCH1 | ENSMMUP00000077296 | ENSMMUP00000022401 | Bone morphogenetic protein 4. | Notch receptor 1. | 0.509 |
BMP4 | SOX9 | ENSMMUP00000077296 | ENSMMUP00000073101 | Bone morphogenetic protein 4. | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. | 0.503 |
BMP4 | TBX3 | ENSMMUP00000077296 | ENSMMUP00000079291 | Bone morphogenetic protein 4. | T-box transcription factor 3. | 0.604 |
CCL17 | CXCL10 | ENSMMUP00000069829 | ENSMMUP00000027500 | C-C motif chemokine 17; Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | 0.787 |
CCL17 | CXCL14 | ENSMMUP00000069829 | ENSMMUP00000006341 | C-C motif chemokine 17; Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine ligand 14. | 0.921 |
CCL17 | TNF | ENSMMUP00000069829 | ENSMMUP00000056761 | C-C motif chemokine 17; Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.585 |
CSRP3 | ANKRD2 | ENSMMUP00000067509 | ENSMMUP00000026346 | Cysteine and glycine rich protein 3. | Ankyrin repeat domain 2. | 0.414 |
CXCL10 | CCL17 | ENSMMUP00000027500 | ENSMMUP00000069829 | C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | C-C motif chemokine 17; Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | 0.787 |
CXCL10 | CXCL14 | ENSMMUP00000027500 | ENSMMUP00000006341 | C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | C-X-C motif chemokine ligand 14. | 0.932 |
CXCL10 | IL18 | ENSMMUP00000027500 | ENSMMUP00000078058 | C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | 0.801 |
CXCL10 | TNF | ENSMMUP00000027500 | ENSMMUP00000056761 | C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.947 |
CXCL14 | CCL17 | ENSMMUP00000006341 | ENSMMUP00000069829 | C-X-C motif chemokine ligand 14. | C-C motif chemokine 17; Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | 0.921 |
CXCL14 | CXCL10 | ENSMMUP00000006341 | ENSMMUP00000027500 | C-X-C motif chemokine ligand 14. | C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | 0.932 |
DDIT3 | TNF | ENSMMUP00000070060 | ENSMMUP00000056761 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.420 |
DLL1 | NOTCH1 | ENSMMUP00000027839 | ENSMMUP00000022401 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 1. | 0.995 |
GDF3 | TBX3 | ENSMMUP00000073766 | ENSMMUP00000079291 | Growth differentiation factor 3. | T-box transcription factor 3. | 0.501 |
IL18 | CXCL10 | ENSMMUP00000078058 | ENSMMUP00000027500 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | 0.801 |
IL18 | TNF | ENSMMUP00000078058 | ENSMMUP00000056761 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.890 |
NOTCH1 | BMP4 | ENSMMUP00000022401 | ENSMMUP00000077296 | Notch receptor 1. | Bone morphogenetic protein 4. | 0.509 |