STRINGSTRING
MSTN MSTN TBX3 TBX3 IL18 IL18 BMP4 BMP4 GDF3 GDF3 MBNL3 MBNL3 SOX9 SOX9 DDIT3 DDIT3 CCL17 CCL17 SOX8 SOX8 CSRP3 CSRP3 EID2B EID2B TNF TNF CXCL14 CXCL14 CMTM5 CMTM5 NMRK2 NMRK2 PPARD PPARD SOSTDC1 SOSTDC1 NOTCH1 NOTCH1 ANKRD2 ANKRD2 CXCL10 CXCL10 ZFHX3 ZFHX3 DLL1 DLL1 TGFB1 TGFB1 PRICKLE1 PRICKLE1 ID3 ID3 TMEM182 TMEM182
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa)
TBX3T-box transcription factor 3. (743 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GDF3Growth differentiation factor 3. (364 aa)
MBNL3Muscleblind like splicing regulator 3. (369 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
CCL17C-C motif chemokine 17; Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (91 aa)
SOX8SRY-box transcription factor 8. (617 aa)
CSRP3Cysteine and glycine rich protein 3. (253 aa)
EID2BEP300-interacting inhibitor of differentiation 2B. (161 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
CXCL14C-X-C motif chemokine ligand 14. (119 aa)
CMTM5CKLF like MARVEL transmembrane domain containing 5. (231 aa)
NMRK2Nicotinamide riboside kinase 2. (235 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform 1. (441 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
NOTCH1Notch receptor 1. (2556 aa)
ANKRD2Ankyrin repeat domain 2. (532 aa)
CXCL10C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)
ZFHX3Zinc finger homeobox 3. (3716 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PRICKLE1Prickle planar cell polarity protein 1. (848 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
TMEM182Uncharacterized protein. (229 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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