STRINGSTRING
IL6ST IL6ST IGF1 IGF1 PDLIM7 PDLIM7 YAP1 YAP1 BMP7 BMP7 WDR63 WDR63 BMPR2 BMPR2 ATRAID ATRAID FBN2 FBN2 GDF10 GDF10 CEBPD CEBPD CCN1 CCN1 SUCO SUCO LTF LTF FFAR4 FFAR4 CLIC1 CLIC1 SFRP2 SFRP2 JAG1 JAG1 SMAD1 SMAD1 ACVR1 ACVR1 ACVR2B ACVR2B WWTR1 WWTR1 CTHRC1 CTHRC1 BMP6 BMP6 PRKD1 PRKD1 IL6R IL6R CCN4 CCN4 TENT5A TENT5A NELL1 NELL1 LRP5 LRP5 BMPR1A BMPR1A TMEM119 TMEM119 BMP4 BMP4 WNT7B WNT7B NPPC NPPC ACVR2A ACVR2A RUNX2 RUNX2 WNT4 WNT4 ZHX3 ZHX3 GDPD2 GDPD2 GLI3 GLI3 BMP2 BMP2 SCUBE3 SCUBE3 FAM20C FAM20C CTNNB1 CTNNB1 ENSMMUP00000062204 ENSMMUP00000062204 SMAD5 SMAD5 PPP3CA PPP3CA SCUBE2 SCUBE2 WNT10B WNT10B SOX11 SOX11 JUND JUND LRP3 LRP3 CEBPB CEBPB IL6 IL6 BMPR1B BMPR1B MEF2C MEF2C FERMT2 FERMT2 DDR2 DDR2 TP63 TP63
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6STUncharacterized protein. (942 aa)
IGF1Insulin like growth factor 1. (208 aa)
PDLIM7PDZ and LIM domain 7. (508 aa)
YAP1Yes associated protein 1. (508 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
WDR63WD repeat domain 63. (891 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ATRAIDEGF-like domain-containing protein. (284 aa)
FBN2Fibrillin 2. (2912 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
CEBPDCCAAT/enhancer-binding protein. (269 aa)
CCN1Cellular communication network factor 1. (381 aa)
SUCOSUN domain containing ossification factor. (1254 aa)
LTFLactotransferrin; Belongs to the transferrin family. (747 aa)
FFAR4Free fatty acid receptor 4. (377 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
WWTR1WW domain containing transcription regulator 1. (432 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
BMP6Bone morphogenetic protein 6. (511 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
IL6RInterleukin 6 receptor. (536 aa)
CCN4WNT1-inducible-signaling pathway protein 1. (367 aa)
TENT5ATerminal nucleotidyltransferase 5A. (442 aa)
NELL1Neural EGFL like 1. (838 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TMEM119Uncharacterized protein. (280 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
NPPCC-type natriuretic peptide. (126 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
RUNX2RUNX family transcription factor 2. (647 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ZHX3Uncharacterized protein. (969 aa)
GDPD2Glycerophosphodiester phosphodiesterase domain containing 2. (642 aa)
GLI3GLI family zinc finger 3. (1580 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (1009 aa)
FAM20CFam20C domain-containing protein. (584 aa)
CTNNB1Catenin beta-1. (781 aa)
ENSMMUP00000062204Uncharacterized protein. (81 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PPP3CASerine/threonine-protein phosphatase. (547 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (1076 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SOX11Transcription factor SOX. (441 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (432 aa)
LRP3Low-density lipoprotein receptor-related protein 3. (770 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
FERMT2PH domain-containing protein. (698 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (896 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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