(17 nodes) Insulin-like growth factor receptor signaling pathway network (Macaca mulatta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	GRB10	Uncharacterized protein. (631 aa)
	GHR	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). (677 aa)
	TSC2	TSC complex subunit 2. (2057 aa)
	IGF1	Insulin like growth factor 1. (208 aa)
	GHSR	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
	AR	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (895 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	GIGYF2	PERQ amino acid-rich with GYF domain-containing protein 2 isoform b. (1302 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	IGF2R	Insulin like growth factor 2 receptor. (2491 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	IGFBP5	Insulin-like growth factor-binding protein 5. (272 aa)
	CRIM1	Cysteine rich transmembrane BMP regulator 1. (1036 aa)
	IRS1	Insulin receptor substrate 1. (1253 aa)
	GIGYF1	GRB10 interacting GYF protein 1. (1035 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AR	ENSMMUP00000061388	ENSMMUP00000015004	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	0.584
AKT1	IGF1	ENSMMUP00000061388	ENSMMUP00000002988	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin like growth factor 1.	0.691
AKT1	IRS1	ENSMMUP00000061388	ENSMMUP00000045227	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.705
AKT1	PIK3R1	ENSMMUP00000061388	ENSMMUP00000015140	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.974
AKT1	TSC2	ENSMMUP00000061388	ENSMMUP00000003781	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	TSC complex subunit 2.	0.976
AR	AKT1	ENSMMUP00000015004	ENSMMUP00000061388	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.584
AR	IGF1	ENSMMUP00000015004	ENSMMUP00000002988	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Insulin like growth factor 1.	0.504
AR	IGF1R	ENSMMUP00000015004	ENSMMUP00000016141	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Tyrosine-protein kinase receptor.	0.594
EIF2AK3	GRB10	ENSMMUP00000012122	ENSMMUP00000026288	Eukaryotic translation initiation factor 2 alpha kinase 3.	Uncharacterized protein.	0.478
GHR	GHSR	ENSMMUP00000001786	ENSMMUP00000005608	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family.	0.401
GHR	IGF1	ENSMMUP00000001786	ENSMMUP00000002988	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	Insulin like growth factor 1.	0.875
GHR	IGF1R	ENSMMUP00000001786	ENSMMUP00000016141	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	Tyrosine-protein kinase receptor.	0.583
GHR	IRS1	ENSMMUP00000001786	ENSMMUP00000045227	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	Insulin receptor substrate 1.	0.441
GHSR	GHR	ENSMMUP00000005608	ENSMMUP00000001786	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family.	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	0.401
GHSR	IGF1	ENSMMUP00000005608	ENSMMUP00000002988	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family.	Insulin like growth factor 1.	0.451
GIGYF1	GRB10	ENSMMUP00000035437	ENSMMUP00000026288	GRB10 interacting GYF protein 1.	Uncharacterized protein.	0.666
GIGYF2	GRB10	ENSMMUP00000016014	ENSMMUP00000026288	PERQ amino acid-rich with GYF domain-containing protein 2 isoform b.	Uncharacterized protein.	0.725
GRB10	EIF2AK3	ENSMMUP00000026288	ENSMMUP00000012122	Uncharacterized protein.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.478
GRB10	GIGYF1	ENSMMUP00000026288	ENSMMUP00000035437	Uncharacterized protein.	GRB10 interacting GYF protein 1.	0.666
GRB10	GIGYF2	ENSMMUP00000026288	ENSMMUP00000016014	Uncharacterized protein.	PERQ amino acid-rich with GYF domain-containing protein 2 isoform b.	0.725