STRINGSTRING
EPHA4 EPHA4 EGR2 EGR2 JPH4 JPH4 PTN PTN NPTN NPTN SHISA7 SHISA7 SLC24A2 SLC24A2 SLC1A1 SLC1A1 STX4 STX4 NSG1 NSG1 SHISA6 SHISA6 SNAP47 SNAP47 GIPC2 GIPC2 S100B S100B SYT12 SYT12 ARF1 ARF1 GIP GIP SYNPR SYNPR SCT SCT STX3 STX3 NTRK2 NTRK2 NEURL1 NEURL1 RIMS3 RIMS3 CX3CL1 CX3CL1 ZZEF1 ZZEF1 GRIN2C GRIN2C GIPC3 GIPC3 NSMF NSMF NR2E1 NR2E1 ADCY1 ADCY1 ATF4 ATF4 EIF4EBP2 EIF4EBP2 DLG4 DLG4 SLC8A3 SLC8A3 JPH3 JPH3 HRH1 HRH1 SYP SYP CYP46A1 CYP46A1 LRRTM2 LRRTM2 CX3CR1 CX3CR1 RIMS2 RIMS2 SNAP25 SNAP25 ENSMMUP00000062989 ENSMMUP00000062989 TNR TNR PAIP2 PAIP2 ERC2 ERC2 P2RX3 P2RX3 SHANK2 SHANK2 RASGRF1 RASGRF1 NEUROD2 NEUROD2 KIT KIT EIF2AK4 EIF2AK4 GSK3B GSK3B NFATC4 NFATC4 GRIA1 GRIA1 FMR1 FMR1 RELN RELN CPEB3 CPEB3 ACE ACE MECP2 MECP2 BAIAP2 BAIAP2 ABL1 ABL1 PLK2 PLK2 SLC8A2 SLC8A2 AKAP5 AKAP5 STAU2 STAU2 SYT7 SYT7 RAB3GAP1 RAB3GAP1 CNTN2 CNTN2 SLC4A10 SLC4A10 EPHB2 EPHB2 APOE APOE ERC1 ERC1 SIPA1L1 SIPA1L1 DGKI DGKI GRIN2A GRIN2A GFAP GFAP RASGRF2 RASGRF2 MPP2 MPP2 GRIK2 GRIK2 GRID2IP GRID2IP BRSK1 BRSK1 BRAF BRAF SYNGR1 SYNGR1 ADCY8 ADCY8 RAPGEF2 RAPGEF2 SYNGAP1 SYNGAP1 ITPR3 ITPR3 LGMN LGMN MEF2C MEF2C CHRDL1 CHRDL1 NCDN NCDN CDC20 CDC20 GRIN1 GRIN1 NCSTN NCSTN MPP6 MPP6 MCTP1 MCTP1 MAP1A MAP1A RGS14 RGS14 SRF SRF PSEN1 PSEN1 LZTS1 LZTS1 DBN1 DBN1 SORCS2 SORCS2 CBLN1 CBLN1 SLC24A1 SLC24A1 HRAS HRAS NETO1 NETO1 CDK5 CDK5 ADGRB1 ADGRB1 SYAP1 SYAP1 PTK2B PTK2B GRIN2B GRIN2B PRKCZ PRKCZ ARC ARC AGER AGER MAP1B MAP1B SYT4 SYT4 PTGS2 PTGS2 PRRT1 PRRT1 NPAS4 NPAS4 PPP3CB PPP3CB SHISA8 SHISA8 KAT2A KAT2A APP APP DRD2 DRD2 TSHZ3 TSHZ3 SHISA9 SHISA9 MAPK1 MAPK1 RARA RARA CRHR2 CRHR2 SCTR SCTR RIMS1 RIMS1 GRM5 GRM5 VGF VGF PRRT2 PRRT2 YTHDF1 YTHDF1 NRGN NRGN PTEN PTEN CALB2 CALB2 ITPKA ITPKA IGSF11 IGSF11 PPFIA3 PPFIA3 NF1 NF1 PENK PENK CALB1 CALB1 MME MME CRTC1 CRTC1 KCNB1 KCNB1 ABHD6 ABHD6 SERPINE2 SERPINE2 GRIN2D GRIN2D NOG NOG GIPC1 GIPC1 SHANK3 SHANK3 SORCS3 SORCS3 DRD5 DRD5 PICK1 PICK1 SCGN SCGN CAMK2B CAMK2B GRID2 GRID2 STAU1 STAU1 KRAS KRAS ZDHHC2 ZDHHC2 CNTN4 CNTN4 ANAPC2 ANAPC2 CLN3 CLN3 LRRTM1 LRRTM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPHA4EPH receptor A4. (1008 aa)
EGR2Uncharacterized protein. (489 aa)
JPH4Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (628 aa)
PTNUncharacterized protein. (172 aa)
NPTNNeuroplastin isoform c. (394 aa)
SHISA7Shisa family member 7. (659 aa)
SLC24A2Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (709 aa)
SLC1A1Excitatory amino acid transporter 3. (524 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (322 aa)
NSG1Neuronal vesicle trafficking associated 1. (185 aa)
SHISA6Shisa family member 6. (553 aa)
SNAP47Synaptosome associated protein 47. (453 aa)
GIPC2PDZ domain-containing protein. (319 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
SYT12Synaptotagmin 12. (436 aa)
ARF1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (217 aa)
GIPGastric inhibitory polypeptide. (153 aa)
SYNPRSynaptoporin isoform 1. (285 aa)
SCTSecretin. (125 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (338 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (575 aa)
RIMS3Regulating synaptic membrane exocytosis protein 3. (308 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
ZZEF1Zinc finger ZZ-type and EF-hand domain containing 1. (3037 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1317 aa)
GIPC3PDZ domain-containing protein. (1440 aa)
NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor. (561 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (390 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
ATF4BZIP domain-containing protein. (351 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E-binding protein 2. (120 aa)
DLG4Uncharacterized protein; Belongs to the MAGUK family. (972 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
JPH3Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (748 aa)
HRH1Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (489 aa)
SYPSynaptophysin. (401 aa)
CYP46A1Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (583 aa)
LRRTM2Leucine-rich repeat transmembrane neuronal protein 2. (516 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1693 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Belongs to the SNAP-25 family. (206 aa)
ENSMMUP00000062989Arc_C domain-containing protein. (471 aa)
TNRUncharacterized protein. (1358 aa)
PAIP2Polyadenylate-binding protein-interacting protein 2. (124 aa)
ERC2ELKS/RAB6-interacting/CAST family member 2. (1040 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (468 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1846 aa)
RASGRF1Ras-specific guanine nucleotide-releasing factor 1. (1273 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1694 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
NFATC4Nuclear factor of activated T cells 4. (961 aa)
GRIA1Uncharacterized protein. (916 aa)
FMR1Fragile X mental retardation 1 protein isoform ISO1. (632 aa)
RELNReelin. (3460 aa)
CPEB3Cytoplasmic polyadenylation element binding protein 3. (768 aa)
ACEAngiotensin-converting enzyme. (1307 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 4. (534 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
AKAP5A-kinase anchoring protein 5. (427 aa)
STAU2Staufen double-stranded RNA binding protein 2. (689 aa)
SYT7Synaptotagmin 7. (708 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (989 aa)
CNTN2Uncharacterized protein. (1040 aa)
SLC4A10Anion exchange protein. (1193 aa)
EPHB2EPH receptor B2. (1082 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1120 aa)
SIPA1L1Signal-induced proliferation-associated 1-like protein 1. (1804 aa)
DGKIDiacylglycerol kinase. (1100 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (462 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1237 aa)
MPP2Uncharacterized protein; Belongs to the MAGUK family. (594 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
GRID2IPGrid2 interacting protein. (1211 aa)
BRSK1Serine/threonine-protein kinase BRSK1. (778 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
SYNGR1Synaptogyrin 1. (431 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1701 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1303 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
LGMNLegumain preproprotein. (433 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
CHRDL1Chordin-like protein 1 isoform 1. (458 aa)
NCDNNeurochondrin isoform 1. (729 aa)
CDC20Cell division cycle protein 20 homolog. (499 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
NCSTNNicastrin. (720 aa)
MPP6Membrane palmitoylated protein 6; Belongs to the MAGUK family. (555 aa)
MCTP1Multiple C2 and transmembrane domain containing 1. (998 aa)
MAP1AMicrotubule associated protein 1A. (3012 aa)
RGS14Regulator of G protein signaling 14. (566 aa)
SRFSerum response factor. (508 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
LZTS1Leucine zipper tumor suppressor 1. (596 aa)
DBN1Drebrin 1. (695 aa)
SORCS2Sortilin related VPS10 domain containing receptor 2. (1161 aa)
CBLN1Cerebellin 1 precursor. (193 aa)
SLC24A1Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1093 aa)
HRASTransforming protein p21. (189 aa)
NETO1Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1. (533 aa)
CDK5Cyclin dependent kinase 5. (364 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1585 aa)
SYAP1Synapse-associated protein 1. (352 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
AGERUncharacterized protein. (403 aa)
MAP1BUncharacterized protein. (2468 aa)
SYT4Synaptotagmin IV. (425 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PRRT1Uncharacterized protein. (346 aa)
NPAS4Neuronal PAS domain protein 4. (802 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
SHISA8Shisa family member 8. (398 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
TSHZ3Teashirt zinc finger homeobox 3. (1081 aa)
SHISA9Shisa family member 9. (424 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
RARARetinoic acid receptor alpha isoform 1. (462 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (431 aa)
SCTRSecretin receptor; Belongs to the G-protein coupled receptor 2 family. (443 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1692 aa)
GRM5Metabotropic glutamate receptor 5 isoform a. (1212 aa)
VGFVGF nerve growth factor inducible. (615 aa)
PRRT2Proline-rich transmembrane protein 2 isoform 1. (340 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (559 aa)
NRGNNeurogranin. (78 aa)
PTENUncharacterized protein. (589 aa)
CALB2Uncharacterized protein. (272 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (461 aa)
IGSF11Uncharacterized protein. (431 aa)
PPFIA3Liprin-alpha-3. (1194 aa)
NF1Neurofibromin 1. (2867 aa)
PENKProenkephalin. (300 aa)
CALB1Calbindin 1. (261 aa)
MMEMembrane metalloendopeptidase. (750 aa)
CRTC1CREB-regulated transcription coactivator 1 isoform 3. (650 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
ABHD6Abhydrolase domain containing 6. (337 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1336 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
GIPC1PDZ domain-containing protein GIPC1 isoform 1. (333 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1730 aa)
SORCS3Sortilin related VPS10 domain containing receptor 3. (1239 aa)
DRD5D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (478 aa)
PICK1Protein interacting with PRKCA 1. (600 aa)
SCGNSecretagogin, EF-hand calcium binding protein. (276 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (668 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
STAU1Double-stranded RNA-binding protein Staufen homolog 1 isoform b. (577 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
ZDHHC2Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (367 aa)
CNTN4Contactin 4. (1029 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (822 aa)
CLN3Battenin. (438 aa)
LRRTM1Leucine-rich repeat transmembrane neuronal protein 1. (522 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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