48 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1317 aa)
	NEURL1	Neuralized E3 ubiquitin protein ligase 1. (575 aa)
	SYNPR	Synaptoporin isoform 1. (285 aa)
	S100B	Protein S100; Belongs to the S-100 family. (92 aa)
	SHISA6	Shisa family member 6. (553 aa)
	SHISA7	Shisa family member 7. (659 aa)
	NPTN	Neuroplastin isoform c. (394 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (1336 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1730 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (668 aa)
	KRAS	KRAS proto-oncogene, GTPase. (412 aa)
	ZDHHC2	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (367 aa)
	CLN3	Battenin. (438 aa)
	EGR2	Uncharacterized protein. (489 aa)
	PPFIA3	Liprin-alpha-3. (1194 aa)
	VGF	VGF nerve growth factor inducible. (615 aa)
	GRM5	Metabotropic glutamate receptor 5 isoform a. (1212 aa)
	SHISA9	Shisa family member 9. (424 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	APP	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa)
	SHISA8	Shisa family member 8. (398 aa)
	SYT4	Synaptotagmin IV. (425 aa)
	ARC	Activity-regulated cytoskeleton-associated protein. (396 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	SYAP1	Synapse-associated protein 1. (352 aa)
	NETO1	Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1. (533 aa)
	HRAS	Transforming protein p21. (189 aa)
	DBN1	Drebrin 1. (695 aa)
	MCTP1	Multiple C2 and transmembrane domain containing 1. (998 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
	NCDN	Neurochondrin isoform 1. (729 aa)
	SYNGAP1	Synaptic Ras GTPase activating protein 1. (1303 aa)
	SYNGR1	Synaptogyrin 1. (431 aa)
	GRIK2	Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
	EPHB2	EPH receptor B2. (1082 aa)
	SLC4A10	Anion exchange protein. (1193 aa)
	CNTN2	Uncharacterized protein. (1040 aa)
	RAB3GAP1	RAB3 GTPase activating protein catalytic subunit 1. (989 aa)
	SLC8A2	Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
	NF1	Neurofibromin 1. (2867 aa)
	RASGRF1	Ras-specific guanine nucleotide-releasing factor 1. (1273 aa)
	ENSMMUP00000062989	Arc_C domain-containing protein. (471 aa)
	SYP	Synaptophysin. (401 aa)
	JPH3	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (748 aa)
	DLG4	Uncharacterized protein; Belongs to the MAGUK family. (972 aa)
	NSMF	NMDA receptor synaptonuclear signaling and neuronal migration factor. (561 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	ARC	ENSMMUP00000018894	ENSMMUP00000024363	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Activity-regulated cytoskeleton-associated protein.	0.444
APP	CNTN2	ENSMMUP00000018894	ENSMMUP00000051164	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Uncharacterized protein.	0.720
APP	DLG4	ENSMMUP00000018894	ENSMMUP00000068361	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Uncharacterized protein; Belongs to the MAGUK family.	0.440
APP	GRIN1	ENSMMUP00000018894	ENSMMUP00000040251	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Glutamate ionotropic receptor NMDA type subunit 1.	0.540
APP	GRIN2B	ENSMMUP00000018894	ENSMMUP00000025129	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Glutamate ionotropic receptor NMDA type subunit 2B.	0.464
APP	GRM5	ENSMMUP00000018894	ENSMMUP00000013314	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Metabotropic glutamate receptor 5 isoform a.	0.403
APP	NF1	ENSMMUP00000018894	ENSMMUP00000008965	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Neurofibromin 1.	0.444
APP	S100B	ENSMMUP00000018894	ENSMMUP00000078551	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Protein S100; Belongs to the S-100 family.	0.546
APP	SYP	ENSMMUP00000018894	ENSMMUP00000066003	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Synaptophysin.	0.755
APP	SYT4	ENSMMUP00000018894	ENSMMUP00000022391	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Synaptotagmin IV.	0.496
ARC	APP	ENSMMUP00000024363	ENSMMUP00000018894	Activity-regulated cytoskeleton-associated protein.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.444
ARC	CAMK2B	ENSMMUP00000024363	ENSMMUP00000003272	Activity-regulated cytoskeleton-associated protein.	Calcium/calmodulin dependent protein kinase II beta.	0.475
ARC	DLG4	ENSMMUP00000024363	ENSMMUP00000068361	Activity-regulated cytoskeleton-associated protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.487
ARC	GRIN2B	ENSMMUP00000024363	ENSMMUP00000025129	Activity-regulated cytoskeleton-associated protein.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.477
CAMK2B	ARC	ENSMMUP00000003272	ENSMMUP00000024363	Calcium/calmodulin dependent protein kinase II beta.	Activity-regulated cytoskeleton-associated protein.	0.475
CAMK2B	DLG4	ENSMMUP00000003272	ENSMMUP00000068361	Calcium/calmodulin dependent protein kinase II beta.	Uncharacterized protein; Belongs to the MAGUK family.	0.603
CAMK2B	ENSMMUP00000062989	ENSMMUP00000003272	ENSMMUP00000062989	Calcium/calmodulin dependent protein kinase II beta.	Arc_C domain-containing protein.	0.468
CAMK2B	GRIN1	ENSMMUP00000003272	ENSMMUP00000040251	Calcium/calmodulin dependent protein kinase II beta.	Glutamate ionotropic receptor NMDA type subunit 1.	0.672
CAMK2B	GRIN2B	ENSMMUP00000003272	ENSMMUP00000025129	Calcium/calmodulin dependent protein kinase II beta.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.807
CAMK2B	GRIN2C	ENSMMUP00000003272	ENSMMUP00000071066	Calcium/calmodulin dependent protein kinase II beta.	Glutamate ionotropic receptor NMDA type subunit 2C.	0.642