(40 nodes) Thymus development network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BCL11B	BAF chromatin remodeling complex subunit BCL11B. (894 aa)
	SLC46A2	Solute carrier family 46 member 2. (475 aa)
	SIX4	SIX homeobox 4. (772 aa)
	CTC1	CST telomere replication complex component 1. (1267 aa)
	EPHB3	EPH receptor B3. (999 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	GATA3	GATA binding protein 3. (444 aa)
	CACNB4	SH3 domain-containing protein. (520 aa)
	PBX1	Pre-B-cell leukemia transcription factor 1 isoform 1. (430 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	BCL2L11	Uncharacterized protein. (292 aa)
	FOXN1	Forkhead box N1. (648 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
	SRF	Serum response factor. (508 aa)
	HAND2	BHLH domain-containing protein. (186 aa)
	FOXE1	Forkhead box E1. (372 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1281 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	CITED4	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (232 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (763 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
	TBX1	T-box transcription factor 1. (496 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	ASXL1	ASXL transcriptional regulator 1. (1541 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (771 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (398 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	MAD1L1	Mitotic arrest deficient 1 like 1. (718 aa)
	PAX1	Paired box 1. (535 aa)
	BCL2	BCL2 apoptosis regulator. (241 aa)
	AIRE	Autoimmune regulator. (614 aa)
	HOXA3	Homeobox A3. (443 aa)
	LMO4	LIM domain only 4. (224 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1081 aa)
	SIX1	SIX homeobox 1. (284 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ASXL1	ENSMMUP00000053665	ENSMMUP00000053692	Tyrosine-protein kinase.	ASXL transcriptional regulator 1.	0.438
ABL1	ATM	ENSMMUP00000053665	ENSMMUP00000005561	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.866
ABL1	CTNNB1	ENSMMUP00000053665	ENSMMUP00000062910	Tyrosine-protein kinase.	Catenin beta-1.	0.696
ABL1	EPHB3	ENSMMUP00000053665	ENSMMUP00000004406	Tyrosine-protein kinase.	EPH receptor B3.	0.917
ABL1	MAPK1	ENSMMUP00000053665	ENSMMUP00000016444	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.544
ABL1	MAPK3	ENSMMUP00000053665	ENSMMUP00000053373	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.471
AIRE	FOXN1	ENSMMUP00000072698	ENSMMUP00000028938	Autoimmune regulator.	Forkhead box N1.	0.779
AIRE	ZMPSTE24	ENSMMUP00000072698	ENSMMUP00000043133	Autoimmune regulator.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.503
ASXL1	ABL1	ENSMMUP00000053692	ENSMMUP00000053665	ASXL transcriptional regulator 1.	Tyrosine-protein kinase.	0.438
ASXL1	CTC1	ENSMMUP00000053692	ENSMMUP00000002588	ASXL transcriptional regulator 1.	CST telomere replication complex component 1.	0.415
ASXL1	JARID2	ENSMMUP00000053692	ENSMMUP00000041668	ASXL transcriptional regulator 1.	Jumonji and AT-rich interaction domain containing 2.	0.492
ATM	ABL1	ENSMMUP00000005561	ENSMMUP00000053665	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.866
ATM	BCL2	ENSMMUP00000005561	ENSMMUP00000069881	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.558
ATM	BRAF	ENSMMUP00000005561	ENSMMUP00000044832	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	B-Raf proto-oncogene, serine/threonine kinase.	0.575
BCL11B	GATA3	ENSMMUP00000080850	ENSMMUP00000009115	BAF chromatin remodeling complex subunit BCL11B.	GATA binding protein 3.	0.483
BCL2	ATM	ENSMMUP00000069881	ENSMMUP00000005561	BCL2 apoptosis regulator.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.558
BCL2	BCL2L11	ENSMMUP00000069881	ENSMMUP00000024235	BCL2 apoptosis regulator.	Uncharacterized protein.	0.996
BCL2	BRAF	ENSMMUP00000069881	ENSMMUP00000044832	BCL2 apoptosis regulator.	B-Raf proto-oncogene, serine/threonine kinase.	0.602
BCL2	CTNNB1	ENSMMUP00000069881	ENSMMUP00000062910	BCL2 apoptosis regulator.	Catenin beta-1.	0.528
BCL2	FADD	ENSMMUP00000069881	ENSMMUP00000061424	BCL2 apoptosis regulator.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.689