STRINGSTRING
IHH IHH DACT1 DACT1 EPB41L5 EPB41L5 ASS1 ASS1 IL6ST IL6ST PKD1 PKD1 EPHB3 EPHB3 YAP1 YAP1 HNF1B HNF1B TYMS TYMS FOXF2 FOXF2 MIXL1 MIXL1 ASCL1 ASCL1 PTK6 PTK6 KCNQ1 KCNQ1 DCHS1 DCHS1 CLMP CLMP SPDEF SPDEF EXT1 EXT1 AHI1 AHI1 CLDN18 CLDN18 PYY PYY FGF9 FGF9 TGFBR2 TGFBR2 CPS1 CPS1 TGFB3 TGFB3 SMO SMO CCDC103 CCDC103 MYOCD MYOCD HOXA13 HOXA13 RET RET SFRP2 SFRP2 NOTCH1 NOTCH1 AGR2 AGR2 SALL1 SALL1 ZIC3 ZIC3 GATA5 GATA5 NKX2-3 NKX2-3 ACVR2B ACVR2B LOC702037 LOC702037 GATA4 GATA4 ALDH1A2 ALDH1A2 PKDCC PKDCC SRC SRC NKX2-6 NKX2-6 PRDM1 PRDM1 GLI1 GLI1 NIPBL NIPBL HMGCS2 HMGCS2 NODAL NODAL CBFA2T2 CBFA2T2 TGFB1 TGFB1 SIX2 SIX2 SFRP1 SFRP1 CHD8 CHD8 CCKBR CCKBR LGR4 LGR4 ADA ADA TP63 TP63 PCSK5 PCSK5 FOXE1 FOXE1 YIPF6 YIPF6 ENSMMUP00000041619 ENSMMUP00000041619 SMAD3 SMAD3 DNAAF1 DNAAF1 MEGF8 MEGF8 STRA6 STRA6 ENSMMUP00000044881 ENSMMUP00000044881 SMAD2 SMAD2 COL3A1 COL3A1 ID2 ID2 FGFR2 FGFR2 RARB RARB RB1 RB1 IFT172 IFT172 EDNRB EDNRB COBL COBL CCDC39 CCDC39 TBX2 TBX2 FGF10 FGF10 SAV1 SAV1 SOX11 SOX11 HIF1A HIF1A TNF TNF GLI2 GLI2 KIT KIT WNT11 WNT11 CTNNB1 CTNNB1 FOXF1 FOXF1 SHOX2 SHOX2 ALX4 ALX4 TGFB2 TGFB2 SHH SHH SOX10 SOX10 NKX2-2 NKX2-2 SOX17 SOX17 GLI3 GLI3 C1GALT1 C1GALT1 VPS52 VPS52 BCL2 BCL2 CCND2 CCND2 NKX3-2 NKX3-2 HOXA5 HOXA5 CXCL8 CXCL8 LOC698302 LOC698302 SCT SCT GATA6 GATA6 WNT5A WNT5A PDGFC PDGFC HOXD13 HOXD13 TCF21 TCF21 BMP4 BMP4 OTC OTC OVOL2 OVOL2 PDX1 PDX1 HLX HLX CDX2 CDX2 FZD5 FZD5 BBS7 BBS7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (837 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
ASS1Argininosuccinate synthase. (412 aa)
IL6STUncharacterized protein. (942 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4298 aa)
EPHB3EPH receptor B3. (999 aa)
YAP1Yes associated protein 1. (508 aa)
HNF1BHepatocyte nuclear factor 1-beta. (557 aa)
TYMSThymidylate synthetase. (313 aa)
FOXF2Forkhead box F2. (446 aa)
MIXL1Mix paired-like homeobox. (240 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (238 aa)
PTK6Tyrosine-protein kinase. (451 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
DCHS1Dachsous cadherin-related 1. (3221 aa)
CLMPCXADR like membrane protein. (373 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
AHI1Abelson helper integration site 1. (1196 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
PYYUncharacterized protein. (205 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CPS1Carbamoyl-phosphate synthase 1. (1529 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
CCDC103Coiled-coil domain containing 103. (242 aa)
MYOCDMyocardin. (986 aa)
HOXA13Homeobox A13. (226 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1115 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
NOTCH1Notch receptor 1. (2556 aa)
AGR2Uncharacterized protein. (175 aa)
SALL1Spalt like transcription factor 1. (1324 aa)
ZIC3Zic family member 3. (466 aa)
GATA5GATA binding protein 5. (397 aa)
NKX2-3NK2 homeobox 3. (364 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
LOC702037Uncharacterized protein. (412 aa)
GATA4GATA binding protein 4. (443 aa)
ALDH1A2Retinal dehydrogenase 2 isoform 1; Belongs to the aldehyde dehydrogenase family. (518 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
SRCTyrosine-protein kinase. (644 aa)
NKX2-6NK2 homeobox 6. (301 aa)
PRDM1PR/SET domain 1. (820 aa)
GLI1Zinc finger protein GLI1 isoform 1. (1106 aa)
NIPBLNipped-B protein. (2804 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
NODALNodal growth differentiation factor. (347 aa)
CBFA2T2CBFA2/RUNX1 partner transcriptional co-repressor 2. (602 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SIX2SIX homeobox 2. (292 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2581 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (450 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
ADAAdenosine deaminase. (390 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1887 aa)
FOXE1Forkhead box E1. (372 aa)
YIPF6Protein YIPF. (237 aa)
ENSMMUP00000041619Uncharacterized protein. (319 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
DNAAF1Dynein assembly factor 1, axonemal. (708 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
STRA6Stimulated by retinoic acid 6. (707 aa)
ENSMMUP00000044881A_deaminase domain-containing protein. (74 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1466 aa)
ID2Inhibitor of DNA binding 2. (203 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
RARBRetinoic acid receptor beta. (448 aa)
RB1Retinoblastoma-associated protein. (928 aa)
IFT172Intraflagellar transport protein 172 homolog. (1749 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (527 aa)
COBLCordon-bleu WH2 repeat protein. (1395 aa)
CCDC39Coiled-coil domain containing 39. (942 aa)
TBX2T-box transcription factor 2. (712 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
SOX11Transcription factor SOX. (441 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
GLI2GLI family zinc finger 2. (1569 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
CTNNB1Catenin beta-1. (781 aa)
FOXF1Forkhead box F1. (432 aa)
SHOX2Short stature homeobox 2. (355 aa)
ALX4ALX homeobox 4. (409 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
SOX10SRY-box transcription factor 10. (467 aa)
NKX2-2Homeobox domain-containing protein. (451 aa)
SOX17SRY-box transcription factor 17. (414 aa)
GLI3GLI family zinc finger 3. (1580 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (371 aa)
VPS52VPS52 subunit of GARP complex. (789 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
CCND2Uncharacterized protein. (353 aa)
NKX3-2Homeobox domain-containing protein. (333 aa)
HOXA5Homeobox A5. (381 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
LOC698302OTCace_N domain-containing protein. (164 aa)
SCTSecretin. (125 aa)
GATA6Transcription factor GATA-6. (595 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (524 aa)
HOXD13Homeobox D13. (343 aa)
TCF21Transcription factor 21. (179 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (455 aa)
OVOL2Transcription factor Ovo-like 2. (275 aa)
PDX1Pancreatic and duodenal homeobox 1. (281 aa)
HLXH2.0 like homeobox. (495 aa)
CDX2Caudal-type homeobox protein 2. (313 aa)
FZD5Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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