(31 nodes) Embryonic digestive tract development network (Macaca mulatta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	HNF1B	Hepatocyte nuclear factor 1-beta. (557 aa)
	FOXF2	Forkhead box F2. (446 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SALL1	Spalt like transcription factor 1. (1324 aa)
	ALDH1A2	Retinal dehydrogenase 2 isoform 1; Belongs to the aldehyde dehydrogenase family. (518 aa)
	PKDCC	Protein kinase domain containing, cytoplasmic. (493 aa)
	NIPBL	Nipped-B protein. (2804 aa)
	SIX2	SIX homeobox 2. (292 aa)
	ADA	Adenosine deaminase. (390 aa)
	PCSK5	Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1887 aa)
	TCF21	Transcription factor 21. (179 aa)
	STRA6	Stimulated by retinoic acid 6. (707 aa)
	ENSMMUP00000044881	A_deaminase domain-containing protein. (74 aa)
	ID2	Inhibitor of DNA binding 2. (203 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	RARB	Retinoic acid receptor beta. (448 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SOX11	Transcription factor SOX. (441 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
	GLI2	GLI family zinc finger 2. (1569 aa)
	FOXF1	Forkhead box F1. (432 aa)
	SHOX2	Short stature homeobox 2. (355 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	VPS52	VPS52 subunit of GARP complex. (789 aa)
	CXCL8	Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	SCT	Secretin. (125 aa)
	OVOL2	Transcription factor Ovo-like 2. (275 aa)
	HLX	H2.0 like homeobox. (495 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A2	STRA6	ENSMMUP00000025625	ENSMMUP00000043400	Retinal dehydrogenase 2 isoform 1; Belongs to the aldehyde dehydrogenase family.	Stimulated by retinoic acid 6.	0.669
CXCL8	FGF10	ENSMMUP00000072289	ENSMMUP00000053581	Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.501
CXCL8	FGF9	ENSMMUP00000072289	ENSMMUP00000012970	Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.487
CXCL8	TNF	ENSMMUP00000072289	ENSMMUP00000056761	Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.915
FGF10	CXCL8	ENSMMUP00000053581	ENSMMUP00000072289	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family.	0.501
FGF10	FGFR2	ENSMMUP00000053581	ENSMMUP00000048184	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.999
FGF10	SHH	ENSMMUP00000053581	ENSMMUP00000065431	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.763
FGF10	TNF	ENSMMUP00000053581	ENSMMUP00000056761	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.486
FGF9	CXCL8	ENSMMUP00000012970	ENSMMUP00000072289	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family.	0.487
FGF9	FGFR2	ENSMMUP00000012970	ENSMMUP00000048184	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.995
FGF9	IHH	ENSMMUP00000012970	ENSMMUP00000001060	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.402
FGF9	SHH	ENSMMUP00000012970	ENSMMUP00000065431	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.704
FGF9	TNF	ENSMMUP00000012970	ENSMMUP00000056761	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.454
FGFR2	FGF10	ENSMMUP00000048184	ENSMMUP00000053581	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.999
FGFR2	FGF9	ENSMMUP00000048184	ENSMMUP00000012970	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.995
FGFR2	IHH	ENSMMUP00000048184	ENSMMUP00000001060	Fibroblast growth factor receptor.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.490
FGFR2	SHH	ENSMMUP00000048184	ENSMMUP00000065431	Fibroblast growth factor receptor.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.462
FOXF1	GLI2	ENSMMUP00000063792	ENSMMUP00000057562	Forkhead box F1.	GLI family zinc finger 2.	0.411
FOXF1	GLI3	ENSMMUP00000063792	ENSMMUP00000067447	Forkhead box F1.	GLI family zinc finger 3.	0.449
FOXF1	IHH	ENSMMUP00000063792	ENSMMUP00000001060	Forkhead box F1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.451