STRINGSTRING
RND2 RND2 PRKCZ PRKCZ GATA4 GATA4 NRP2 NRP2 SEMA5A SEMA5A CDK5 CDK5 VCL VCL STK11 STK11 PDLIM5 PDLIM5 LIMK1 LIMK1 NRN1L NRN1L SRF SRF PAK6 PAK6 DDR1 DDR1 EDNRA EDNRA NRP1 NRP1 SPAG6 SPAG6 AURKA AURKA SEMA3F SEMA3F PLXNA3 PLXNA3 MAP2K4 MAP2K4 SEMA7A SEMA7A DVL1 DVL1 ULK2 ULK2 DCX DCX SSNA1 SSNA1 LAMB2 LAMB2 COBL COBL ENSMMUP00000053874 ENSMMUP00000053874 ADRA1A ADRA1A MEX3C MEX3C BDNF BDNF RAPH1 RAPH1 PLXNA1 PLXNA1 RYK RYK EIF2AK4 EIF2AK4 ENSMMUP00000062234 ENSMMUP00000062234 WASF1 WASF1 EDN1 EDN1 TNR TNR CTNNB1 CTNNB1 SORBS2 SORBS2 EMX1 EMX1 ARIH2 ARIH2 LLPH LLPH GDF9 GDF9 SLIT3 SLIT3 NRN1 NRN1 POU4F2 POU4F2 NIN NIN RNF6 RNF6 SOX9 SOX9 EDN3 EDN3 WNT5A WNT5A DCLK1 DCLK1 LPAR3 LPAR3 SH3GL2 SH3GL2 FOXL2 FOXL2 ULK1 ULK1 SPART SPART CYFIP1 CYFIP1 ITGA4 ITGA4 JADE2 JADE2 FLRT1 FLRT1 TNN TNN SLIT2 SLIT2 LHX2 LHX2 IMPACT IMPACT NDN NDN EXT1 EXT1 ALCAM ALCAM TGFBR2 TGFBR2 SEMA5B SEMA5B SLIT1 SLIT1 AKAP13 AKAP13 SLC9A6 SLC9A6 IQGAP1 IQGAP1 CDH4 CDH4 RARG RARG SHBG SHBG SPG11 SPG11 APP APP PPP3CB PPP3CB KMT2D KMT2D PRMT2 PRMT2 EDN2 EDN2 HDAC6 HDAC6 C15H9orf72 C15H9orf72 AUTS2 AUTS2 MAP1B MAP1B EFNA5 EFNA5 FLRT3 FLRT3 SEMA3A SEMA3A TMEM108 TMEM108
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RND2Rho-related GTP-binding protein RhoN. (227 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
GATA4GATA binding protein 4. (443 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (925 aa)
SEMA5AUncharacterized protein. (1080 aa)
CDK5Cyclin dependent kinase 5. (364 aa)
VCLVinculin. (1134 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (433 aa)
PDLIM5PDZ and LIM domain 5. (686 aa)
LIMK1LIM domain kinase 1 isoform 1. (647 aa)
NRN1LNeuritin 1 like. (166 aa)
SRFSerum response factor. (508 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (939 aa)
EDNRAUncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
SPAG6Sperm associated antigen 6. (509 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
PLXNA3Plexin A3. (1892 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
SEMA7ASemaphorin-7A isoform 1 preproprotein; Belongs to the semaphorin family. (664 aa)
DVL1Dishevelled segment polarity protein 1. (695 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1025 aa)
DCXDoublecortin. (387 aa)
SSNA1Sjoegren syndrome nuclear autoantigen 1. (119 aa)
LAMB2Laminin subunit beta-2. (1798 aa)
COBLCordon-bleu WH2 repeat protein. (1395 aa)
ENSMMUP00000053874RWD domain-containing protein. (293 aa)
ADRA1AAdrenoceptor alpha 1A. (445 aa)
MEX3CMex-3 RNA binding family member C. (705 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1309 aa)
PLXNA1Plexin A1. (2015 aa)
RYKReceptor like tyrosine kinase. (611 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1694 aa)
ENSMMUP00000062234RBR-type E3 ubiquitin transferase. (228 aa)
WASF1Wiskott-Aldrich syndrome protein family member 1. (559 aa)
EDN1Preproendothelin-1. (211 aa)
TNRUncharacterized protein. (1358 aa)
CTNNB1Catenin beta-1. (781 aa)
SORBS2Sorbin and SH3 domain containing 2. (1246 aa)
EMX1Homeobox protein EMX1. (290 aa)
ARIH2RBR-type E3 ubiquitin transferase. (470 aa)
LLPHProtein LAPS18-like protein. (129 aa)
GDF9Growth/differentiation factor 9 preproprotein. (455 aa)
SLIT3Slit guidance ligand 3. (1530 aa)
NRN1Uncharacterized protein. (195 aa)
POU4F2POU domain protein. (408 aa)
NINNinein. (2163 aa)
RNF6Ring finger protein 6. (725 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
EDN3Endothelin 3. (257 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
DCLK1Doublecortin like kinase 1. (759 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (383 aa)
FOXL2Forkhead box L2. (376 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1049 aa)
SPARTSpartin. (666 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
JADE2Jade family PHD finger 2. (911 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (674 aa)
TNNTenascin N. (1299 aa)
SLIT2Slit guidance ligand 2. (1529 aa)
LHX2LIM/homeobox protein Lhx2. (406 aa)
IMPACTProtein IMPACT. (320 aa)
NDNNecdin. (321 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
ALCAMCD166 antigen isoform 1. (583 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SEMA5BSemaphorin 5B. (1113 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
AKAP13A-kinase anchoring protein 13. (2899 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (701 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1667 aa)
CDH4Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (916 aa)
RARGRetinoic acid receptor gamma. (454 aa)
SHBGSex hormone binding globulin. (495 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2487 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
KMT2DLysine methyltransferase 2D. (5578 aa)
PRMT2Protein arginine N-methyltransferase 2 isoform 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (433 aa)
EDN2Endothelin 2. (206 aa)
HDAC6UBP-type domain-containing protein. (1257 aa)
C15H9orf72Uncharacterized protein. (481 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (1225 aa)
MAP1BUncharacterized protein. (2468 aa)
EFNA5EPH-related receptor tyrosine kinase ligand 7; Belongs to the ephrin family. (228 aa)
FLRT3Fibronectin-like domain-containing leucine-rich transmembrane protein 3. (649 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
TMEM108Transmembrane protein 108. (575 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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